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CAREER: A meta-omics approach to discover the determinants of micropollutant biotransformations performed by wastewater microbial communities

职业：采用元组学方法来发现废水微生物群落进行微污染物生物转化的决定因素

基本信息

批准号：
1748982
负责人：
Damian Helbling
金额：
$ 50万
依托单位：
Cornell University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1748982&HistoricalAwards=false
关键词：
CAREER meta omics approach discover

项目摘要

This project seeks to improve water quality through enhanced wastewater treatment to protect public health and improve the environment. Many types of pollutants are poorly removed by existing wastewater treatment technologies. As a result, pollutants accumulate in aquatic environments and may contaminate drinking water resources. The PI will study the mechanisms by which organic pollutants are transformed during wastewater treatment through detailed characterization of the complex organic matter in wastewater using advanced chemical analysis tools. This information will be coupled with next generation genetic characterization of the microbes responsible for pollutant removal to allow optimization of wastewater treatment plant performance to more efficiently remove pollutants and decrease cost. The education plan for this project will train a diverse group of students to broaden participation in environmental engineering and other STEM fields.The occurrence of anthropogenic organic micropollutants in wastewater treatment plant effluents raises concerns about their human-health and ecological impacts. As wastewater reclamation and recycling become more widely adopted, efficient and cost-effective means for micropollutant removal are becoming essential. This research seeks to leverage the broad metabolic capabilities of wastewater microbial communities to achieve this goal. The research will utilize high-resolution mass spectrometry to broadly infer the metabolic functioning of microbial communities and next-generation sequencing to characterize the structure of microbial communities from population to functional levels with a goal of identifying taxa, ecological features, metabolic pathways, or operational parameters that lead to enhanced micropollutant biotransformation. This research is significant because it will provide wastewater utilities with an effective means for optimizing bioprocesses to meet emerging performance objectives. The PI will create opportunities for diverse groups of students across all education levels to engage with water quality research through a collaboration with the Cayuga Lake Floating Classroom for pre-college students, recruit undergraduate students to work on the research plan through the NSF-funded Louis Stokes Alliance for Minority Participation program, and integrate research and education activities in the undergraduate environmental engineering curriculum at Cornell University. The education plan is significant because it will create opportunities for students to explore water quality problems outside the classroom and develop skills in self-directed learning in environmental engineering or other STEM fields.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在通过加强废水处理来改善水质，以保护公众健康和改善环境。现有的废水处理技术很难去除许多类型的污染物。因此，污染物在水生环境中积累，并可能污染饮用水资源。PI将通过使用先进的化学分析工具详细表征废水中的复杂有机物，研究有机污染物在废水处理过程中的转化机制。这些信息将与负责污染物去除的下一代微生物的遗传特征相结合，以优化污水处理厂的性能，从而更有效地去除污染物并降低成本。该项目的教育计划将培养多样化的学生群体，以扩大环境工程和其他STEM领域的参与。人为有机微污染物在污水处理厂出水中的出现引起了人们对其对人类健康和生态影响的关注。随着废水回收和循环利用的广泛采用，高效和经济的微污染物去除手段变得至关重要。本研究旨在利用废水微生物群落的广泛代谢能力来实现这一目标。该研究将利用高分辨率质谱法广泛推断微生物群落的代谢功能，并利用下一代测序从种群到功能水平表征微生物群落的结构，目的是确定类群、生态特征、代谢途径或导致微污染物生物转化增强的操作参数。这项研究具有重要意义，因为它将为废水公用事业提供优化生物过程以满足新兴绩效目标的有效手段。该项目将通过与卡尤加湖浮动课堂合作，为不同教育水平的学生创造参与水质研究的机会，通过美国国家科学基金会资助的路易斯·斯托克斯少数民族参与联盟项目，招募本科生参与研究计划，并将研究和教育活动整合到康奈尔大学的本科生环境工程课程中。该教育计划意义重大，因为它将为学生创造机会，在课堂外探索水质问题，并在环境工程或其他STEM领域培养自主学习的技能。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Target and suspect screening for biocides in drinking water resources of Honduras

洪都拉斯饮用水源中杀菌剂的目标和可疑物筛查

DOI：
10.2166/h2oj.2022.140
发表时间：
2022
期刊：
H2Open Journal
影响因子：
2.1
作者：
Sherman, Anya;Mejia, Walter Alejandro Guardado;Padilla, Natasha Ramos;Carpenter, Corey M. G.;Rich, Stephanie L.;Moncada, Erika Tenorio;Helbling, Damian E.
通讯作者：
Helbling, Damian E.

Engineering of managed aquifer recharge systems to optimize biotransformation of trace organic chemicals