CAREER:Functional contributions of lateral parietal cortex to episodic memory
职业:外侧顶叶皮层对情景记忆的功能贡献
基本信息
- 批准号:1752921
- 负责人:
- 金额:$ 75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is a remarkable feature of human memory that people can vividly re-experience events from the past by bringing these experiences back to mind on command. Over the past two decades, neuroimaging studies have consistently found that the parietal cortex plays a role in this ability to re-experience the past. However, the specific way in which parietal cortex contributes to human memory remains a topic of substantial debate. With the support of this CAREER award, Dr. Kuhl will use a combination of functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and advanced statistical approaches to determine how memories are encoded in distributed patterns of activity in parietal cortex. Studies will determine how parietal representations of memories are shaped by behavioral goals, how these representations evolve over time, and how parietal cortex interacts with other brain regions during acts of remembering. The research will culminate in a computational understanding of the role of parietal cortex in memory. This will critically inform theories of human memory and will be relevant to understanding how and why memory function is impaired. Additionally, research findings and analysis approaches from these studies will be used to generate a novel, project-based math curriculum for a local middle school, helping to raise interest in and awareness of STEM careers. In this project, Human fMRI studies will be used to identify how memory representations are encoded in distributed patterns of activity in parietal cortex. Forward encoding models will be used to predict the activity pattern that a given stimulus will elicit in parietal cortex. These models will be based on the semantic properties of that stimulus (i.e., stimulus content) and the "memory status" of that stimulus (i.e., whether the stimulus is remembered from a past experience). Dr. Kuhl will then test how parietal memory representations are influenced by top-down behavioral goals. It is predicted that compared to representations in sensory cortex, parietal representations will be more sensitive to behavioral goals. This prediction is motivated by a theoretical perspective wherein parietal cortex functions as an interface between sensory cortex and prefrontal cortex. Related to this prediction, EEG decoding studies will track the timing with which memory representations emerge in parietal cortex. It is expected that parietal representations will temporally lag those in sensory areas, and will exhibit coherence with prefrontal representations leading up to behavioral decisions. The overarching goal is to develop a new theoretical account of how parietal cortex contributes to memory via internal computations and interactions with other brain regions. The research activities will also provide insight into how parietal cortex contributes to cognitive processes more generally.
人类记忆的一个显著特征是,人们可以通过命令将这些经历带回脑海来生动地重新体验过去的事件。在过去的二十年里,神经影像学研究一直发现顶叶皮层在这种重新体验过去的能力中发挥着作用。然而,顶叶皮层对人类记忆的具体贡献方式仍然是一个有争议的话题。在这个职业奖的支持下,Kuhl博士将使用功能性磁共振成像(fMRI),脑电图(EEG)和先进的统计方法来确定记忆是如何编码在顶叶皮层的分布式活动模式中的。研究将确定记忆的顶叶表征是如何由行为目标塑造的,这些表征如何随着时间的推移而演变,以及顶叶皮层在记忆行为中如何与其他大脑区域相互作用。这项研究最终将通过计算理解顶叶皮层在记忆中的作用。这将为人类记忆理论提供重要信息,并将与理解记忆功能受损的方式和原因有关。此外,这些研究的研究结果和分析方法将用于为当地中学生成一个新颖的基于项目的数学课程,帮助提高对STEM职业的兴趣和认识。在这个项目中,人类的功能磁共振成像研究将被用来确定如何在顶叶皮层的活动分布模式的记忆表征编码。前向编码模型将用于预测给定刺激将在顶叶皮层中引起的活动模式。这些模型将基于该刺激的语义属性(即,刺激内容)和该刺激的“记忆状态”(即,刺激是否是从过去的经历中记住的)。然后,库尔博士将测试顶叶记忆表征如何受到自上而下的行为目标的影响。据预测,与感觉皮层的表征相比,顶叶表征对行为目标更敏感。这种预测是由一个理论的角度,其中顶叶皮层功能之间的界面感觉皮层和前额叶皮层的动机。与这一预测相关的是,脑电图解码研究将跟踪记忆表征在顶叶皮层出现的时间。据估计,顶叶表征在时间上会滞后于感觉区的表征,并表现出与前额叶表征的一致性,从而导致行为决策。总体目标是开发一种新的理论解释顶叶皮层如何通过内部计算和与其他大脑区域的相互作用来促进记忆。研究活动还将提供关于顶叶皮层如何更普遍地促进认知过程的见解。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Decomposing Parietal Memory Reactivation to Predict Consequences of Remembering
- DOI:10.1093/cercor/bhy200
- 发表时间:2019-08-01
- 期刊:
- 影响因子:3.7
- 作者:Lee, Hongmi;Samide, Rosalie;Kuhl, Brice A.
- 通讯作者:Kuhl, Brice A.
Adaptive Memory Distortions Are Predicted by Feature Representations in Parietal Cortex
适应性记忆扭曲是通过顶叶皮层的特征表示来预测的
- DOI:10.1523/jneurosci.2875-20.2021
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Zhao, Yufei;Chanales, Avi J.;Kuhl, Brice A.
- 通讯作者:Kuhl, Brice A.
Parietal Representations of Stimulus Features Are Amplified during Memory Retrieval and Flexibly Aligned with Top-Down Goals
- DOI:10.1523/jneurosci.0564-18.2018
- 发表时间:2018-09-05
- 期刊:
- 影响因子:5.3
- 作者:Favila, Serra E.;Samide, Rosalie;Kuhl, Brice A.
- 通讯作者:Kuhl, Brice A.
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