Versatile Synthesis of Chlorophylls and Bacteriochlorophylls for Fundamental Studies in Photosynthesis

用于光合作用基础研究的叶绿素和细菌叶绿素的多功能合成

基本信息

  • 批准号:
    1760839
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-07-01 至 2021-06-30
  • 项目状态:
    已结题

项目摘要

The Chemical Synthesis Program of the Chemistry Division supports the project by Professor Jonathan S. Lindsey. Professor Lindsey is a faculty member in the Department of Chemistry at North Carolina State University. He is developing methods to create chlorophylls and bacteriochlorophylls (molecules that nature used to harvest energy from light) in the laboratory from simple starting materials in a straightforward manner. The synthesis of (bacterio)chlorophylls has never been fully accomplished in this manner. The ability to build such molecules along with analogues will afford a much deeper understanding of energy flow in photosynthesis (an area that impacts biophysics, plant sciences, energy generation), the nature of metabolic breakdown products (an area that impacts ecology, global carbon balance), and the chemical properties of such compounds (an area that impacts nutrition, medicine). The project mainly involves organic chemistry but will also impact diverse areas of science including understanding of photosynthesis. Thus, the project is well suited for the education and training of scientists in a collaborative environment. Professor Lindsey's group is well-positioned to provide this experience for students underrepresented in science. In addition, outreach activities involving North Carolina teachers will also be part of the funded project. Chlorophylls and bacteriochlorophylls are the chief pigments in photosynthetic organisms, including plants, cyanobacteria, and anoxygenic photosynthetic bacteria. The lack of synthetic methods for preparing (bacterio)chlorophylls and analogues constitutes an intellectual and technical deficit in the photosynthetic sciences. The Lindsey lab proposes to fill this chasm by developing robust methods for synthesis of such valuable macrocycles. The particular challenges in synthesizing (bacterio)chlorophylls include (1) the stereochemistry of substituents in the pyrroline ring(s), (2) the fifth (isocyclic) ring, and (3) substituents arrayed about the perimeter of the macrocycle. The intellectual merit of the work concerns the development of routes for the synthesis of the key photosynthetic pigments and analogues; the latter have broad impact (beyond the scope of the present grant) encompassing studies of quantum coherence in photosynthesis and catabolism in ecology. A key outcome is a methodology in heterocyclic chemistry for preparing pyrroles, pyrrolines, dipyrromethanes, hydrodipyrrins, and phyllobilins relevant to the (bacterio)chlorophylls of photosynthesis. The broader impacts entail professional development of middle and high school science teachers to improve teaching of photosynthesis (via a chlorophyll-based experiment) in schools and to inspire middle and high school students to STEM, thereby broadening the participation of underrepresented groups.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
化学系的化学合成项目支持乔纳森·S·琳赛林赛教授是北卡罗来纳州州立大学化学系的教员。他正在开发在实验室中以简单的起始材料以直接的方式创造叶绿素和细菌叶绿素(大自然用于从光中获取能量的分子)的方法。(细菌)叶绿素的合成从未以这种方式完全完成。与类似物一起沿着构建这种分子的能力将使人们更深入地了解光合作用中的能量流动(影响生物物理学,植物科学,能源生产的领域),代谢分解产物的性质(影响生态学,全球碳平衡的领域)以及这些化合物的化学性质(影响营养,医学的领域)。 该项目主要涉及有机化学,但也将影响不同的科学领域,包括对光合作用的理解。因此,该项目非常适合在协作环境中对科学家进行教育和培训。 Lindsey教授的小组有能力为科学领域代表性不足的学生提供这种经验。 此外,涉及北卡罗来纳州教师的外展活动也将是资助项目的一部分。 叶绿素和细菌叶绿素是光合生物的主要色素,包括植物、蓝细菌和不产氧光合细菌。 缺乏制备(细菌)叶绿素和类似物的合成方法构成了光合科学的知识和技术缺陷。 Lindsey实验室建议通过开发用于合成这种有价值的大环化合物的稳健方法来填补这一鸿沟。 合成(细菌)叶绿素的特殊挑战包括(1)吡咯啉环中取代基的立体化学,(2)第五(异环)环,和(3)围绕大环周边排列的取代基。这项工作的智力价值涉及关键光合色素和类似物的合成路线的发展;后者具有广泛的影响(超出了本补助金的范围),包括光合作用和生态学中的量子相干性研究。 一个关键的成果是杂环化学的方法,用于制备吡咯,吡咯啉,dipyrromethanes,氢二吡咯,和叶绿素相关的(细菌)叶绿素的光合作用。 更广泛的影响需要初中和高中科学教师的专业发展,以改善光合作用的教学(通过基于叶绿素的实验)在学校,并激励初中和高中学生干,该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查进行评估,被认为值得支持的搜索.

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Synthesis of the Ring C Pyrrole of Native Chlorophylls and Bacteriochlorophylls
天然叶绿素和细菌叶绿素的C环吡咯的合成
  • DOI:
    10.1021/acs.joc.9b01650
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Wang, Pengzhi;Chau Nguyen, Khiem;Lindsey, Jonathan S.
  • 通讯作者:
    Lindsey, Jonathan S.
Riley Oxidation of Heterocyclic Intermediates on Paths to Hydroporphyrins—A Review
杂环中间体的 Riley 氧化生成氢卟啉的途径 — 综述
  • DOI:
    10.3390/molecules25081858
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    Wang, Pengzhi;Lindsey, Jonathan S.
  • 通讯作者:
    Lindsey, Jonathan S.
Synthesis of AD-Dihydrodipyrrins Equipped with Latent Substituents of Native Chlorophylls and Bacteriochlorophylls
带有天然叶绿素和细菌叶绿素潜在取代基的 AD-二氢二吡林的合成
  • DOI:
    10.1021/acs.joc.1c01239
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Wang, Pengzhi;Lindsey, Jonathan S.
  • 通讯作者:
    Lindsey, Jonathan S.
Synthesis of model bacteriochlorophylls containing substituents of native rings A, C and E
  • DOI:
    10.1039/d1nj02469h
  • 发表时间:
    2021-07-08
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Chung, Duy T. M.;Tran, Phuong Vy;Lindsey, Jonathan S.
  • 通讯作者:
    Lindsey, Jonathan S.
Study of conditions for streamlined assembly of a model bacteriochlorophyll from two dihydrodipyrrin halves
  • DOI:
    10.1039/d0nj04855k
  • 发表时间:
    2021-01-14
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Nguyen, Khiem Chau;Wang, Pengzhi;Lindsey, Jonathan S.
  • 通讯作者:
    Lindsey, Jonathan S.
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Jonathan Lindsey其他文献

Jonathan Lindsey的其他文献

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{{ truncateString('Jonathan Lindsey', 18)}}的其他基金

Versatile Synthesis of Chlorophylls and Bacteriochlorophylls for Fundamental Studies in Photosynthesis
用于光合作用基础研究的叶绿素和细菌叶绿素的多功能合成
  • 批准号:
    2348052
  • 财政年份:
    2024
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Versatile Synthesis of Chlorophylls and Bacteriochlorophylls for Fundamental Studies in Photosynthesis
用于光合作用基础研究的叶绿素和细菌叶绿素的多功能合成
  • 批准号:
    2054497
  • 财政年份:
    2021
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
A Chemical Model for the Prebiotic Origins of Tetrapyrrole Macrocycles
四吡咯大环化合物益生元起源的化学模型
  • 批准号:
    1305105
  • 财政年份:
    2013
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
A Chemical Model for the Prebiotic Origins of Tetrapyrrole Macrocycles
四吡咯大环化合物益生元起源的化学模型
  • 批准号:
    0953010
  • 财政年份:
    2010
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
Photonic, Electronic, and Optoelectronic Materials for Molecular Devices
用于分子器件的光子、电子和光电材料
  • 批准号:
    9988142
  • 财政年份:
    2000
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
Synthesis and Physico-Chemical Characterization of Molecular Optoelectronic Gates
分子光电门的合成及物理化学表征
  • 批准号:
    9707995
  • 财政年份:
    1997
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant

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