Development of New Catalytic Reactions for the Synthesis of Natural Products

化学合成在分子医学、农用化学品、香料和香料以及材料科学等领域发挥着重要的作用。因此，开发和应用新的、选择性的、高效的功能分子合成工艺是一个具有广泛社会影响的基础研究领域。由该奖项资助的Sarah Reisman博士的研究正在研究新的催化反应，作为碳-碳键结构的关键，以提高合成复杂分子的效率，利用廉价和丰富的金属镍。研究小组正在开发新的反应，将不同的反应伙伴结合起来，作为合成生物活性分子的战略步骤。这些研究为分子在医药和农用化学品中的应用提供了更有效和可持续的途径。Reisman博士致力于在帕萨迪纳联合学区（Pasadena Unified School District）改善科学、技术、工程和数学（STEM）教育课程的推广活动，并对鼓励年轻女性从事STEM职业特别感兴趣。在化学部化学合成项目的资助下，加州理工学院的Sarah Reisman博士正在开发镍催化的交叉亲电偶联反应（CEC），作为天然产物全合成的战略反应。碳-碳和碳杂原子键的合成新方法的发展，以及这些方法与越来越复杂的合成策略的结合，推动了结构复杂、功能分子合成的进步。Reisman博士和她的研究小组正在开发新的镍催化的双不对称还原烷基化反应来制备大环，以及镍催化的聚合片段偶联反应来制备二萜天然产物。本研究为镍催化的交叉亲电偶联反应的基础研究做出了贡献，并展示了如何将镍催化的C(sp2)-C（sp3）键构建纳入合成策略。Reisman博士与加州理工学院教学、学习和推广中心以及社区科学院合作，正在开发有机化学实验，以加强帕萨迪纳联合学区（PUSD）的高中科学课程。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

Chemical synthesis plays an important and often rate-limiting role in the fields of molecular medicine, agrochemicals, flavors and fragrances, and materials science. The development and application of new, selective, and efficient processes for the synthesis of functional molecules is therefore a fundamental area of research with broad societal impact. Dr. Sarah Reisman's research funded by this award is investigating new catalytic reactions as key carbon-carbon bond constructions for the synthesis of complex molecules with improved efficiency using the inexpensive and abundant metal, nickel. The research team is developing new reactions that couple different reaction partners as strategic steps in the synthesis of biologically active molecules. These investigations are providing more efficient and sustainable access to molecules with applications in medicine and agrochemicals. Dr. Reisman is engaged in outreach activities focused on improving curriculum for science, technology, engineering and mathematics (STEM) education in the Pasadena Unified School District, with a specific interest in encouraging young women to pursue STEM careers. With funding from the Chemical Synthesis Program of the Chemistry Division, Dr. Sarah Reisman at the California Institute of Technology is developing Ni-catalyzed cross-electrophile coupling (CEC) reactions as strategic reactions for natural product total synthesis. Advances in the synthesis of structurally complex, functional molecules are driven by the development of new synthetic methods to prepare carbon-carbon and carbon-heteroatom bonds, and the incorporation of these methods into increasingly sophisticated synthetic strategies. Dr. Reisman and her research team are developing new Ni-catalyzed double asymmetric reductive alkenylation reactions to prepare macrocycles, and Ni-catalyzed convergent fragment coupling reactions to prepare diterpenoid natural products. This research is contributing fundamental studies of Ni-catalyzed cross- electrophile coupling reactions, and demonstrating how Ni-catalyzed C(sp2)-C(sp3) bond constructions can be incorporated into synthetic strategy. In partnership with the Caltech Center for Teaching, Learning, and Outreach and the Community Science Academy, Dr. Reisman is developing organic chemistry experiments to enhance high school science curriculum in the Pasadena Unified School District (PUSD).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.