Coordination of bacterial two component system signaling (P15)

细菌双组分系统信号传导的协调（P15）

• 批准号: 233357356
• 金额: --
• 依托单位: Institut für Neuropathologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/233357356?language=en
• 关键词: Coordination; bacterial; two; component; system

Project P15 (Hunke) analyzes the role of accessory proteins in coordinating bacterial two-component signaling (TCS) forming a microcompartment in the bacterial plasma membrane. The E. coli Cpx-TCS detects and responds to perturbations of the bacterial envelope and transmits signals within and between bacterial membranes. The group will (a) determine the molecular basis of the communication between CpxA receptor and the soluble CpxP (b) analyze how the Cpx-TCS system interacts with the outer membrane lipoprotein NlpE to allow signaling across two membranes, and (c) unravel how signaling is coordinated with transcription.

项目P15(Hunke)分析了辅助蛋白在协调细菌双组分信号(TCS)形成细菌质膜微室中的作用。大肠杆菌CPX-TCS检测和响应细菌包膜的扰动，并在细菌膜内和细菌膜之间传输信号。该小组将(A)确定CpxA受体和可溶性CpxP之间通信的分子基础(B)分析CPx-TCS系统如何与外膜脂蛋白NlpE相互作用以允许信号通过两个膜，以及(C)揭示信号如何与转录协调。