Collaborative Research: A Point-of-Care Device for Diagnosis and Management of Pulmonary Diseases

肺癌是癌症相关死亡的最常见原因。症状，如发烧或疲劳，是非特异性的，而其他指标是典型的许多其他疾病。开发一种可靠的技术，在尽可能早的阶段检测肺癌，对于成功的结果至关重要。几种竞争技术证明了它们诊断中晚期肺癌的能力，但未能检测早期癌症，这显著降低了它们的效用。该项目将合成一套新的光学生物传感器和指示器，这些传感器和指示器与早期肺癌有关。这种新型的非侵入性、成本效益高且可靠的筛查工具的开发将对整个肺癌预防领域产生变革性影响。该团队将通过专注于一组生物标志物（基质金属蛋白酶和组织蛋白酶）来实现技术原理验证，这些生物标志物已被证明可以成功检测1期非小细胞肺癌（NSCLC），这是最常见的肺癌形式。一个集成的微流体装置将被开发来处理一类新的纳米生物传感器，旨在检测大量的酶。将由拟议设备检测的生物标志物组将首先基于从动物模型收集的样本进行优化，然后是人类患者。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估而被认为值得支持。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估而被认为值得支持。

Lung cancer is the most common cause of cancer-related death. Symptoms, such as fever or fatigue, are unspecific while other indicators are typical of many other diseases. Development of a reliable technique that detects lung cancer at the earliest possible stage, is critical for successful outcomes. Several competing techniques demonstrated their ability to diagnose intermediate and late stage lung cancer, but failed to detect early stage cancer which significantly decreases their utility. This project will synthesize a set of novel optical biosensors and indicators that have been implicated in early stage lung cancer. The development of this novel non-invasive, cost effective, and reliable screening tool would be transformative for the whole field of lung cancer prevention. The team will achieve technical proof-of-principle by focusing on a set of biomarkers (matrix metalloproteinases and cathepsins) that have been shown to be successful in detecting stage 1 non-small-cell lung cancer (NSCLC), the most common form of lung cancer. An integrated microfluidic device will be developed to handle a new class of nano-biosensors designed to detect a large number of enzymes. The panel of biomarkers that will be detected by the proposed device will be optimized based on samples collected from animal models first, and human patients later. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteriaThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.