SGER: Biophotonics: Nano-based Contrast Agent for Molecular Optical-based Imaging of Prostate Cancer

SGER：生物光子学：用于前列腺癌分子光学成像的纳米造影剂

• 批准号: 0632281
• 负责人: Massoud Motamedi
• 金额: --
• 依托单位: University of Texas Medical Branch at Galveston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0632281&HistoricalAwards=false
• 关键词: SGER; Biophotonics; Nano; based; Contrast

Motamedi0632281The applicant proposes to enhance prostate tumor targeting by functionalizing nanogold particles with aptamers that specifically will bind to prostatic specific membrane antigen (PSMA), a well characterized antigen expressed on the surface of prostate cancer cells. This antigen could provide an ideal targeting site with high affinity for early in vivo molecular imaging of prostate cancer. The goal of the project is to demonstrate the ability to design, functionalize and optimize gold particles for in vivo targeting of PSMA for early detection of prostate cancer using optical imaging techniques.

motamedi063281申请人提出通过功能化纳米金颗粒与适体特异性结合前列腺特异性膜抗原（PSMA）来增强前列腺肿瘤靶向性，PSMA是一种在前列腺癌细胞表面表达的特异性抗原。该抗原可为前列腺癌早期体内分子成像提供一个理想的靶向位点，具有较高的亲和力。该项目的目标是展示设计、功能化和优化金颗粒的能力，利用光学成像技术在体内靶向PSMA，用于前列腺癌的早期检测。