Biophotonics: Collaborative Research: Photo-activated Coupling of Nanoparticle Multilayers and Nerve Cells

生物光子学：合作研究：纳米粒子多层和神经细胞的光激活耦合

• 批准号: 0119544
• 负责人: Massoud Motamedi
• 金额: --
• 依托单位: University of Texas Medical Branch at Galveston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0119544&HistoricalAwards=false
• 关键词: Biophotonics; Collaborative; Research; Photo; activated

0119544 Motamedi Recent advances in nanotechnology and bioengineering have opened the exciting prospect for promoting direct interaction of electronics, optics and biological systems. The primary obstacle to realizing this goal in the fields of neuroscience and medical devices such as prostheses is the inadequate understanding of the molecular processes involved in coupling between living neurons and nanomaterials, and how to optimize the coupling between man made materials and living systems. In this project, the intent is to investigate the dynamics and mechanisms of the live/lifeless matter interaction in a model system consisting of a thin film composed of nanoparticles and cultured nerve cells. The multi-disciplinary and multi- institutional "Linked Collaborative Proposals" bring together several research groups with broad expertise and research interest to conduct experimental and theoretical studies aimed at characterizing the interaction that occur at the interface of nanomaterials and neurons and optimizing the interface for effective photon-activation of neurons following photonic probing of the interface of nanomaterials that are attached to the cells. The partners at Oklahoma State University lead by Dr. Kotov will carry out the materials science aspect of this project, while the investigation at the University of Texas Medical Branch lead by Dr. Motamedi will concentrate on the bioengineering and electrophysiological components of this work. Specifically, the objectives of the project are the following. (1) Preparation of biocompatible nanoparticle multilayers that can be attached to nerve cells. (2) Registration and characterization of the photoinduced nerve cell membrane currents and potentials following optical excitation of the interface as function of NP and biological structures. (3) Optimization of NP-cell coupling for different interface structure.

0119544 Motamedi纳米技术和生物工程的最新进展为促进电子、光学和生物系统的直接相互作用开辟了令人兴奋的前景。在神经科学和假体等医疗器械领域实现这一目标的主要障碍是对活神经元和纳米材料之间耦合所涉及的分子过程以及如何优化人造材料和生命系统之间的耦合的理解不足。在这个项目中，目的是研究在由纳米颗粒和培养的神经细胞组成的薄膜组成的模型系统中活/无生命物质相互作用的动力学和机制。多学科及多机构的“连系合作建议”汇集了多个具有广泛专业知识及研究兴趣的研究小组，进行实验及理论研究，旨在表征纳米材料与神经元界面的相互作用，并优化界面，以便在光子探测附着于细胞的纳米材料界面后，有效地光子激活神经元。由Kotov博士领导的俄克拉荷马州州立大学的合作伙伴将开展该项目的材料科学方面的研究，而由Motamedi博士领导的德克萨斯大学医学分支的研究将集中在这项工作的生物工程和电生理部分。 具体而言，该项目的目标如下。(1)可附着于神经细胞的生物相容性纳米粒子多层膜的制备。(2)配准和表征的光诱导神经细胞膜电流和电位后，作为NP和生物结构的函数的接口的光激发。(3)不同界面结构的NP-细胞耦合优化。