EAGER:Nanoimaging for Molecular Diagnosis of Retina

EAGER：用于视网膜分子诊断的纳米成像

• 批准号: 1053978
• 负责人: Massoud Motamedi
• 金额: $ 29.73万
• 依托单位: University of Texas Medical Branch at Galveston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1053978&HistoricalAwards=false
• 关键词: EAGER; Nanoimaging; Molecular; Diagnosis; Retina

1053978MotamediA multidisciplinary team of investigators with expertise in ophthalmology, retinal biochemistry, advanced optical imaging, and biomedical engineering from the University of Texas Medical Branch (UTMB) in collaboration with Dr. Vainrub from Auburn University with expertise in the development of super resolution microscopy technique for nanoimaging, will develop and test a multimodal imaging system for early detection and monitoring of retinal pathology induced by conditions such as retinopathy and traumatic brain injury. Multiplatform imaging system including autofluorescence, confocal scanning laser ophthalmology (SLO), Fourier domain optical coherence tomography (FDOCT), adaptive optics (AO), and fluorescence imaging - used in multimodal combination can provide high resolution molecular images of the retina with potentially cellular resolution. SLO, FDOCT, and PISRM will be used to quantify the spatial and temporal distributions of endogenous and exogenous biomarkers and nano-based contrast agent designed for detection of inflammatory responses as a function of disease progression.

1053978 MotamediA多学科团队的研究人员具有专长的眼科学，视网膜生物化学，先进的光学成像，和生物医学工程从得克萨斯大学医学分支（UTMB）与博士. Vainrub从奥本大学与专业知识的发展超分辨率显微镜技术的纳米成像，将开发和测试一种多模式成像系统，用于早期检测和监测视网膜病变和创伤性脑损伤等疾病引起的视网膜病变。多平台成像系统包括自体荧光、共焦扫描激光眼科学（SLO）、傅立叶域光学相干断层扫描（FDOCT）、自适应光学（AO）和荧光成像-以多模态组合使用，可以提供具有潜在细胞分辨率的视网膜的高分辨率分子图像。SLO、FDOCT和PISRM将用于量化内源性和外源性生物标志物以及纳米造影剂的空间和时间分布，这些生物标志物和纳米造影剂设计用于检测作为疾病进展函数的炎症反应。