EAGER:Nanoimaging for Molecular Diagnosis of Retina

1053978研究人员团队拥有眼科、视网膜生物化学、高级光学成像和生物医学工程方面的专业知识，来自德克萨斯大学医学部(UTMB)，与奥本大学的VainRUB博士合作，开发和测试一种多模式成像系统，用于早期检测和监控视网膜病变和创伤性脑损伤等疾病引起的视网膜病理。多模式组合使用的多平台成像系统，包括自发荧光、共焦扫描激光眼科(SLO)、傅立叶域光学相干断层成像(FDOCT)、自适应光学(AO)和荧光成像，可以提供具有潜在细胞分辨率的高分辨率视网膜分子图像。SLO、FDOCT和PISRM将用于量化内源性和外源性生物标志物和纳米造影剂的空间和时间分布，这些造影剂旨在检测炎症反应作为疾病进展的函数。

1053978MotamediA multidisciplinary team of investigators with expertise in ophthalmology, retinal biochemistry, advanced optical imaging, and biomedical engineering from the University of Texas Medical Branch (UTMB) in collaboration with Dr. Vainrub from Auburn University with expertise in the development of super resolution microscopy technique for nanoimaging, will develop and test a multimodal imaging system for early detection and monitoring of retinal pathology induced by conditions such as retinopathy and traumatic brain injury. Multiplatform imaging system including autofluorescence, confocal scanning laser ophthalmology (SLO), Fourier domain optical coherence tomography (FDOCT), adaptive optics (AO), and fluorescence imaging - used in multimodal combination can provide high resolution molecular images of the retina with potentially cellular resolution. SLO, FDOCT, and PISRM will be used to quantify the spatial and temporal distributions of endogenous and exogenous biomarkers and nano-based contrast agent designed for detection of inflammatory responses as a function of disease progression.