High-speed and minimally photo-damaging STED microscopy using nanolaser arrays

使用纳米激光阵列的高速且光损伤最小的 STED 显微镜

• 批准号: 1805200
• 负责人: Kyu Young Han
• 金额: $ 60万
• 依托单位: The University of Central Florida Board of Trustees
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1805200&HistoricalAwards=false
• 关键词: speed; minimally; photo; damaging; STED

This project will develop a fast, affordable, and miniaturized microscopy system to image the fine ultrastructure of cells, with minimal photodamage or photobleaching of fluorescent probes. Success of this proposal will significantly advance the field of microscopy, specifically super-resolution fluorescence imaging. The development of high-performance, fast, compact and affordable microscopes will impact medical diagnostics such as cancer and Alzheimer's disease. The principal investigator will develop the next generation of stimulated emission depletion (STED) microscopy for high-performance, fast, compact and affordable STED microscopes. The PI will integrate metallic nanolaser arrays into STED systems which will greatly improve imaging speed and reduce the size and cost of the equipmentThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将开发一种快速、经济和小型化的显微镜系统，以成像细胞的精细超微结构，并将荧光探针的光损伤或光漂白降至最低。这一提议的成功将极大地推动显微镜领域的发展，特别是超分辨率荧光成像。高性能、快速、紧凑和负担得起的显微镜的发展将对癌症和阿尔茨海默病等医学诊断产生影响。首席研究人员将开发下一代受激辐射耗尽(STED)显微镜，用于高性能、快速、紧凑和负担得起的STED显微镜。PI将把金属纳米激光器阵列集成到STED系统中，这将极大地提高成像速度并减少设备的尺寸和成本。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Low‐photobleaching line‐scanning confocal microscopy using dual inclined beams

• DOI: 10.1002/jbio.201900075
• 发表时间: 2019-06
• 期刊: Journal of Biophotonics
• 影响因子: 2.8
• 作者: Jialei Tang;K. Y. Han

Direct modulation of electrically pumped coupled microring lasers

电泵耦合微环激光器的直接调制

• DOI: 10.1364/oe.442076
• 发表时间: 2022
• 期刊: Optics Express
• 影响因子: 3.8
• 作者: Xu, Chi;Hayenga, William E.;Christodoulides, Demetrios N.;Khajavikhan, Mercedeh;LiKamWa, Patrick
• 通讯作者: LiKamWa, Patrick

Nanolaser-based emulators of spin Hamiltonians

基于纳米激光的自旋哈密顿量模拟器

• DOI: 10.1515/nanoph-2020-0230
• 发表时间: 2020
• 期刊: Nanophotonics
• 影响因子: 7.5
• 作者: Parto, Midya;Hayenga, William E.;Marandi, Alireza;Christodoulides, Demetrios N.;Khajavikhan, Mercedeh
• 通讯作者: Khajavikhan, Mercedeh

Realizing spin Hamiltonians in nanoscale active photonic lattices

• DOI: 10.1038/s41563-020-0635-6
• 发表时间: 2019-12
• 期刊: Nature Materials
• 影响因子: 41.2
• 作者: M. Parto;W. Hayenga;A. Marandi;D. Christodoulides;M. Khajavikhan

Time‐Resolved Second‐Order Coherence Characterization of Broadband Metallic Nanolasers

• DOI: 10.1002/lpor.202000593
• 发表时间: 2021-10
• 期刊: Laser & Photonics Reviews
• 影响因子: 11
• 作者: Agnes George;A. Bruhacs;A. Aadhi;W. Hayenga;Rachel Ostic;Erin Whitby;M. Kues;Zhiming Wang;C. Reimer;M. Khajavikhan;R. Morandotti