Superchiral Light Generation on Achiral Substrates for High Sensitive Detection of Chiral Molecules

非手性基底上的超手性光产生用于手性分子的高灵敏度检测

基本信息

批准号：
1808045
负责人：
Debashis Chanda
金额：
$ 35.99万
依托单位：
The University of Central Florida Board of Trustees
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1808045&HistoricalAwards=false
关键词：
Superchiral Light Generation Achiral Substrates

项目摘要

Chirality is a ubiquitous property of life, found at many levels of biological systems from left-handed amino acids to right-handed glucose. It gives rise to the inherent chirality to DNAs, proteins and more, which remained hitherto unexplored due to the unavailability of precise characterization techniques. These chiral biomolecules can be present in both handed symmetries with undistinguishable physical properties, such as density, molecular weight or electronic and vibrational transitions frequencies making them almost impossible to differentiate with common spectroscopic techniques. Here a unique achiral plasmonic surface is proposed, which outperforms previous approaches. In the preliminary work chiral molecule detection sensitivity that is four orders of magnitude higher compared to the conventional technique, but without the extensive and tedious sample preparation and at much lower sample volume, is demonstrated. Pharmacological and toxicological characterization of chiral molecules plays a crucial role in the pharmaceutical drug industry and FDA approval process. The proposed project will also serve to train graduate students in nanolithography and device fabrication. Based on these attributes the proposed novel molecular chirality detection scheme has high potential to generate commercial interests and can become real world sensing technique in near future.Technical: The proposed unique cavity-coupled achiral plasmonic surface outperforms previous approaches in the following aspects: It does not have geometrical chirality, hence no chiral signal from the substrate; It creates strong near-fields on the upper surface exposed to the target analyte; The near-field is 100% single-handed chiral and flip handedness depending only on the excitation handedness on the same substrate. Such a unique mechanism of superchiral near-field generation is possible due to the coherent interaction between degenerate plasmonic and photonic cavity modes. These attributes are exclusive compared to any previous attempts where inhomogeneous chiral near-field and structural CD diminishes chiral signal from molecules. In the preliminary studies, chiral light-matter interaction through surface enhanced vibrational circular dichroism with about four orders of magnitude enhancement in detection sensitivity compared to conventional volumetric CD (VCD) technique is demonstrated. The proposed system will permit efficient chiral-light matter interactions for the detection of vibrational molecular chirality in the MIR domain relevant for drug screening. Unlike previous demonstrations where two independent chiral substrates with opposite handedness were needed, the proposed work promises chiral near-field interaction on a single achiral plasmonic substrate paving the path towards surface enhanced chiroptical spectroscopy.The main focus of the project will be to develop a sensitive chiral compound identification technique using our achiral plasmonic substrates. The system will be benchmarked with pharmacologically significant chiral drug compounds like Ibuprofen, Thalidomide, propranolol, Albuterol, and Isoflurane. These chiral compounds will allow us to start the characterization of the system and will further expand. The pharmacological and toxicological characterization of enantiomers plays a crucial role in the pharmaceutical drug industry and FDA approval process. Therefore, there is still an active need for efficient enantiomer detection, precisely and cheaply. We strongly believe that the proposed research will allow us to overcome some of the previous challenges and enable us to develop a low cost, high throughput, high sensitive chiral molecule detection technique.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

手性是生命中无处不在的特性，在从左撇子氨基酸到右手葡萄糖的许多级别的生物系统中发现。它引起了DNA，蛋白质等的固有手性，由于精确表征技术的不可用而迄今未探索。这些手性生物分子可以存在于两种手的对称性中，具有不可分割的物理特性，例如密度，分子量或电子和振动过渡的频率，几乎不可能通过公共光谱技术区分它们。在这里，提出了独特的运动等离子表面，它的表现优于先前的方法。在初步工作中，手性分子检测敏感性比常规技术高四个数量级，但没有广泛而乏味的样品制备和较低的样品体积。手性分子的药理和毒理学特征在药物工业和FDA批准过程中起着至关重要的作用。拟议的项目还将用于培训研究生纳米光刻和设备制造。基于这些属性，提出的新型分子性手性检测方案具有很高的产生商业利益的潜力，并且可以在不久的将来成为现实世界感测技术。技术：拟议的独特型腔耦合性achiral等离激子表面在以下方面超过以前的方法：它没有地质的手续性，因此没有质地的性格，因此没有质地的信号。它在暴露于目标分析物的上表面上产生强大的近场；近场是100％单手性手性和翻转手的，这仅取决于同一基板上的激发手。由于退化等离子型和光子腔模式之间的相干相互作用，因此可以使用这种独特的近场近场产生机制。与以前的任何尝试相比，这些属性是独有的，因为近场和结构CD降低了分子的手性信号。在初步研究中，与常规的体积CD（VCD）技术相比，手性光 - 通过表面增强的振动圆二色性相互作用，检测灵敏度的大约四个数量级增强。提出的系统将允许有效的手性光质相互作用，以检测与药物筛查相关的miR域中振动分子性手性。与以前的演示不同的是，需要两个具有相反手的独立手性底物，拟议的工作承诺在单个疗法浆膜上的手性近场相互作用铺平了通往表面增强的手势光谱的路径。该项目的主要重点将使用我们的敏感的奇特的复合识别技术，使用我们的授权型纤维化元素。该系统将以药理学上重要的手性药物化合物等基准测试，例如布洛芬，沙利度胺，普萘洛尔，沙丁胺醇和异氟烷。这些手性化合物将使我们能够开始对系统的表征，并将进一步扩展。对映异构体的药理和毒理学特征在制药药业和FDA批准过程中起着至关重要的作用。因此，仍然需要精确，便宜地进行有效的对映异构体检测。我们坚信，拟议的研究将使我们能够克服以前的一些挑战，并使我们能够发展低成本，高吞吐量，高灵敏的手性分子检测技术。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识绩效和更广泛影响的评估来通过评估来支持的，这是值得的。