Collaborative Research: Nanodiamond Particle Fabrication by Confined Laser Shock Detonation for Drug Delivery and Other Applications

合作研究：通过受限激光冲击爆炸制造纳米金刚石颗粒用于药物输送和其他应用

• 批准号: 1825739
• 负责人: Yanyao Jiang
• 金额: $ 22.51万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1825739&HistoricalAwards=false
• 关键词: Collaborative; Research; Nanodiamond; Particle; Fabrication

Nanodiamonds, or nanosized diamond particles, have been widely explored as drug delivery vehicles and bio-imaging agents for biomedical treatments ranging from oncology to infection to regenerative medicine. However, the manufacture of medical quality nanodiamonds is difficult, costly, and energy intensive. The existing methods for nanodiamond fabrication often rely on a chemical detonation process, which suffers from poor controllability, complex experimental set-ups, and safety issues. This award supports fundamental research to provide knowledge needed for the development of a simple and cost-effective nanomanufacturing process to fabricate nanodiamonds under ambient conditions. Using this easy and viable route for nanodiamond fabrication, many complex nanodiamond-based devices for biomedical, electronics, and optics applications can be built at low cost. Such a capability impacts key U.S. industries thus enhancing national prosperity and security. The research results will be integrated into a comic book -- Nanodiamond Nora and Neal -- targeted at engaging K-12 students. In addition, this project provides an integrated training platform for undergraduate and graduate students, and promotes broadening participation of women and underrepresented students in research.This project aims to establish a new nanomanufacturing strategy for nanodiamond fabrication. It is hypothesized that the laser-induced plasma in the nanosecond pulsed laser shock processing, can provide sufficient energy input and duration to promote the graphite-to-diamond phase transition. To test this hypothesis, a confined laser shock detonation approach is planned to realize the scalable nanomanufacturing of nanodiamonds at room-temperature and in open air, through utilizing high-energy laser-matter interaction phenomena. The major research objective is to establish a fundamental understanding of mechanisms involved in the confined laser shock detonation process that are responsible for the growth of nanodiamonds. First-principles modeling and molecular dynamics simulations performed at ASU and UNR, help understand the laser-graphite interactions and the plasma dynamics that lead to the graphite-to-diamond phase transition. Biocompatibility of laser-fabricated nanodiamonds is evaluated through collaboration between ASU and UCLA to demonstrate potential applications in drug delivery and bio-imaging. This project contributes to advances in laser-based nanomanufacturing and innovations in nanomaterials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米肌或纳米化钻石颗粒已被广泛探索为药物和生物成像剂的生物医学治疗剂，从肿瘤学到感染再到再生医学。 但是，医疗质量的纳米登蒙蒙德人的制造是困难，昂贵且能量密集型的。 现有的纳米梁制造方法通常依赖于化学爆炸过程，该过程遭受了可控性不佳，复杂的实验设置和安全问题的影响。 该奖项支持基本研究，以提供开发简单且具有成本效益的纳米制造过程所需的知识，以在环境条件下制造纳米座。 使用这种简单可行的途径用于纳米原子制造，许多用于生物医学，电子和光学应用程序的基于纳米座的复杂设备都可以低成本构建。 这样的能力影响了美国的主要行业，从而增强了国家的繁荣和安全。 研究结果将融入一本漫画书-Nanodiamond Nora和Neal，旨在吸引K-12学生。 此外，该项目为本科和研究生提供了一个综合的培训平台，并促进了妇女和代表性不足的学生参与研究。该项目旨在建立一种新的纳米原子制造策略。 假设纳秒脉冲激光冲击处理中激光诱导的血浆可以提供足够的能量输入和持续时间，以促进石墨至二氨基相变。 为了检验这一假设，计划通过利用高能量激光 - 摩擦相互作用现象，实现宽大的激光冲击方法，以实现在室温和露天处的纳米座纳米制造的可扩展纳米制造。 主要的研究目标是建立对涉及纳米蒙蒙德人增长的受限激光冲击过程机制的基本理解。 在ASU和UNR上执行的第一原理建模和分子动力学模拟，有助于了解激光 - 石膏相互作用以及导致石墨至二摩on相变的等离子体动力学。 通过ASU和UCLA之间的协作来评估激光制造的纳米座的生物相容性，以证明在药物输送和生物成像中的潜在应用。 该项目有助于基于激光的纳米制造和纳米材料创新的进步。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的审查标准，认为值得通过评估来获得支持。

项目成果

Modeling for Chemical-Etching Enhanced Pulsed Laser Ablation

化学蚀刻增强脉冲激光烧蚀建模

• DOI: 10.1115/msec2019-2844
• 发表时间: 2019
• 期刊: Proceedings of the ASME 2019 14th International Manufacturing Science and Engineering Conference
• 作者: Zhang, Xing;Mao, Bo;Histed, Rebecca;Liao, Yiliang
• 通讯作者: Liao, Yiliang

Understanding the mechanism of shockwave induced graphite-to-diamond phase transition

了解冲击波诱导石墨到金刚石相变的机制

• DOI: 10.1016/j.mtla.2022.101487
• 发表时间: 2022
• 期刊: Materialia
• 影响因子: 3.4
• 作者: Sun, Haofan;Jiang, Xinyu;Dai, Rui;Liu, Lei;Wang, Zuyuan;Zhang, Xing;Zhuang, Houlong;Liao, Yiliang;Nian, Qiong
• 通讯作者: Nian, Qiong

Understanding the Laser-Matter Interaction and Plasma Dynamics in Nanosecond Pulsed Laser Shock Processing: A First Principle Study

了解纳秒脉冲激光冲击处理中的激光与物质相互作用和等离子体动力学：第一原理研究

• DOI: 10.1115/msec2019-2848
• 发表时间: 2019
• 期刊: Proceedings of the ASME 2019 14th International Manufacturing Science and Engineering Conference
• 作者: Mao, Bo;Liao, Yiliang
• 通讯作者: Liao, Yiliang

Nanosecond laser shock detonation of nanodiamonds: from laser-matter interaction to graphite-to-diamond phase transition

纳米金刚石的纳秒激光冲击爆炸：从激光-物质相互作用到石墨-金刚石相变

• DOI: 10.1088/2631-7990/ac37f1
• 发表时间: 2021
• 期刊: International Journal of Extreme Manufacturing
• 影响因子: 14.7
• 作者: Zhang, Xing;Sun, Haofan;Mao, Bo;Dai, Rui;Zhuang, Houlong;Liao, Yiliang;Nian, Qiong
• 通讯作者: Nian, Qiong