Collaborative Research: Nanodiamond Particle Fabrication by Confined Laser Shock Detonation for Drug Delivery and Other Applications

合作研究：通过受限激光冲击爆炸制造纳米金刚石颗粒用于药物输送和其他应用

• 批准号: 1825739
• 负责人: Yanyao Jiang
• 金额: $ 22.51万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2022-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1825739&HistoricalAwards=false
• 关键词: Collaborative; Research; Nanodiamond; Particle; Fabrication

Nanodiamonds, or nanosized diamond particles, have been widely explored as drug delivery vehicles and bio-imaging agents for biomedical treatments ranging from oncology to infection to regenerative medicine. However, the manufacture of medical quality nanodiamonds is difficult, costly, and energy intensive. The existing methods for nanodiamond fabrication often rely on a chemical detonation process, which suffers from poor controllability, complex experimental set-ups, and safety issues. This award supports fundamental research to provide knowledge needed for the development of a simple and cost-effective nanomanufacturing process to fabricate nanodiamonds under ambient conditions. Using this easy and viable route for nanodiamond fabrication, many complex nanodiamond-based devices for biomedical, electronics, and optics applications can be built at low cost. Such a capability impacts key U.S. industries thus enhancing national prosperity and security. The research results will be integrated into a comic book -- Nanodiamond Nora and Neal -- targeted at engaging K-12 students. In addition, this project provides an integrated training platform for undergraduate and graduate students, and promotes broadening participation of women and underrepresented students in research.This project aims to establish a new nanomanufacturing strategy for nanodiamond fabrication. It is hypothesized that the laser-induced plasma in the nanosecond pulsed laser shock processing, can provide sufficient energy input and duration to promote the graphite-to-diamond phase transition. To test this hypothesis, a confined laser shock detonation approach is planned to realize the scalable nanomanufacturing of nanodiamonds at room-temperature and in open air, through utilizing high-energy laser-matter interaction phenomena. The major research objective is to establish a fundamental understanding of mechanisms involved in the confined laser shock detonation process that are responsible for the growth of nanodiamonds. First-principles modeling and molecular dynamics simulations performed at ASU and UNR, help understand the laser-graphite interactions and the plasma dynamics that lead to the graphite-to-diamond phase transition. Biocompatibility of laser-fabricated nanodiamonds is evaluated through collaboration between ASU and UCLA to demonstrate potential applications in drug delivery and bio-imaging. This project contributes to advances in laser-based nanomanufacturing and innovations in nanomaterials.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

纳米钻石或纳米钻石颗粒已被广泛用作药物输送载体和生物成像剂，用于从肿瘤学到感染再到再生医学的生物医学治疗。然而，医用质量的纳米钻石的制造是困难的、昂贵的和能源密集型的。现有的纳米金刚石制备方法通常依赖于化学爆炸过程，该过程存在可控性差、实验装置复杂和安全问题。该奖项支持基础研究，以提供开发一种简单且成本效益高的纳米制造工艺所需的知识，以便在环境条件下制造纳米钻石。利用这种简单可行的纳米金刚石制造方法，可以以低成本制造许多用于生物医学、电子和光学应用的复杂的纳米金刚石器件。这种能力会影响美国的关键产业，从而增强国家繁荣和安全。研究成果将被整合到一本漫画书中--纳米钻石诺拉和尼尔--目标是吸引K-12学生。此外，该项目为本科生和研究生提供了一个综合培训平台，并促进女性和代表性不足的学生更广泛地参与研究。该项目旨在建立一种新的纳米钻石制造战略。假设在纳秒脉冲激光冲击处理中，激光诱导等离子体可以提供足够的能量输入和持续时间来促进石墨到金刚石的相变。为了验证这一假设，利用高能激光与物质的相互作用现象，设计了一种受限激光冲击爆轰方法，在室温和露天条件下实现了纳米金刚石的可伸缩纳米制造。主要的研究目标是建立对限制激光冲击爆轰过程中导致纳米钻石生长的机制的基本了解。在亚利桑那州立大学和北卡罗来纳大学进行的第一性原理建模和分子动力学模拟，有助于理解导致石墨到钻石相变的激光-石墨相互作用和等离子体动力学。通过亚利桑那州立大学和加州大学洛杉矶分校的合作，评估了激光制造的纳米钻石的生物兼容性，以展示在药物输送和生物成像方面的潜在应用。该项目为基于激光的纳米制造和纳米材料创新做出了贡献。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Modeling for Chemical-Etching Enhanced Pulsed Laser Ablation

化学蚀刻增强脉冲激光烧蚀建模

• DOI: 10.1115/msec2019-2844
• 发表时间: 2019
• 期刊: Proceedings of the ASME 2019 14th International Manufacturing Science and Engineering Conference
• 作者: Zhang, Xing;Mao, Bo;Histed, Rebecca;Liao, Yiliang
• 通讯作者: Liao, Yiliang

Understanding the mechanism of shockwave induced graphite-to-diamond phase transition

了解冲击波诱导石墨到金刚石相变的机制

• DOI: 10.1016/j.mtla.2022.101487
• 发表时间: 2022
• 期刊: Materialia
• 影响因子: 3.4
• 作者: Sun, Haofan;Jiang, Xinyu;Dai, Rui;Liu, Lei;Wang, Zuyuan;Zhang, Xing;Zhuang, Houlong;Liao, Yiliang;Nian, Qiong
• 通讯作者: Nian, Qiong

Nanosecond laser shock detonation of nanodiamonds: from laser-matter interaction to graphite-to-diamond phase transition

纳米金刚石的纳秒激光冲击爆炸：从激光-物质相互作用到石墨-金刚石相变

• DOI: 10.1088/2631-7990/ac37f1
• 发表时间: 2021
• 期刊: International Journal of Extreme Manufacturing
• 影响因子: 14.7
• 作者: Zhang, Xing;Sun, Haofan;Mao, Bo;Dai, Rui;Zhuang, Houlong;Liao, Yiliang;Nian, Qiong
• 通讯作者: Nian, Qiong

Understanding the Laser-Matter Interaction and Plasma Dynamics in Nanosecond Pulsed Laser Shock Processing: A First Principle Study

了解纳秒脉冲激光冲击处理中的激光与物质相互作用和等离子体动力学：第一原理研究

• DOI: 10.1115/msec2019-2848
• 发表时间: 2019
• 期刊: Proceedings of the ASME 2019 14th International Manufacturing Science and Engineering Conference
• 作者: Mao, Bo;Liao, Yiliang
• 通讯作者: Liao, Yiliang