MRI: Acquisition of an integrated Confocal and TIRF fluorescence microscope for multidisciplinary research and teaching at Barnard College

MRI：巴纳德学院采购一台集成共焦和 TIRF 荧光显微镜，用于多学科研究和教学

• 批准号: 1828264
• 负责人: Christina Vizcarra
• 金额: $ 56.33万
• 依托单位: Barnard College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828264&HistoricalAwards=false
• 关键词: MRI; Acquisition; integrated; Confocal; TIRF

An award is made to Barnard College to purchase a multi-functional fluorescence microscope. As a liberal arts college for women, Barnard is committed to training the next generation of female scientists. Toward this goal, science majors often spend several years working in a research lab in addition to their upper-level laboratory coursework. In both of these settings, technologically advanced instrumentation, like the microscope purchased with this award, provide important hands-on training for students. Among the undergraduate women who will use the microscope are students in the Science Pathways Scholars Program at Barnard. This program is embedded in the college's research mission and provides financial support and training opportunities to students from groups that are traditionally underrepresented in the sciences.The microscope has specialized capabilities for imaging cells and tissues and for observing single biological molecules in action. This instrument acquisition will benefit research in three departments at Barnard. One group in biology will use the microscope to track specific cells and their offspring during mouse development. Another biology group will look at honeybee guts to understand how parasites colonize this environmentally-important insect. Two faculty from neuroscience will observe brain structures that are related to circadian rhythms and to fear and anxiety. In the chemistry department, research groups will use the microscope to study proteins that are associated with hereditary deafness as well as a protein that has a role in the neurotoxicity of lead exposure. Cutting-edge microscopy will positively impact research and undergraduate science education at Barnard.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

巴纳德学院获得了购买多功能荧光显微镜的奖励。作为一所女子文理学院，巴纳德学院致力于培养下一代女科学家。为了实现这一目标，理科专业的学生除了完成高级的实验课程外，通常还要花几年时间在研究实验室工作。在这两种情况下，技术先进的仪器，如该奖项购买的显微镜，为学生提供重要的实践培训。在将使用显微镜的女大学生中，有巴纳德大学科学之路学者项目的学生。该项目嵌入了学院的研究使命，并为来自传统上在科学领域代表性不足的群体的学生提供经济支持和培训机会。显微镜具有对细胞和组织成像以及观察单个生物分子活动的专门能力。这台仪器的收购将有利于巴纳德大学三个部门的研究。生物学的一个小组将使用显微镜来追踪老鼠发育过程中的特定细胞及其后代。另一个生物学小组将研究蜜蜂内脏，以了解寄生虫如何在这种对环境至关重要的昆虫中定居。神经科学的两名教员将观察与昼夜节律、恐惧和焦虑相关的大脑结构。在化学系，研究小组将使用显微镜研究与遗传性耳聋相关的蛋白质，以及一种与铅接触的神经毒性有关的蛋白质。尖端显微镜将对巴纳德大学的研究和本科科学教育产生积极影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Evolutionary assembly and disassembly of the mammalian sternum

哺乳动物胸骨的进化组装和拆卸

• DOI: 10.1016/j.cub.2022.11.055
• 发表时间: 2023
• 期刊: Current Biology
• 影响因子: 9.2
• 作者: Brent, Ava E.;Buchholtz, Emily A.;Mansfield, Jennifer H.
• 通讯作者: Mansfield, Jennifer H.

Phase Gradients and Anisotropy of the Suprachiasmatic Network: Discovery of Phaseoids

• DOI: 10.1523/eneuro.0078-21.2021
• 发表时间: 2021-09-01
• 期刊: ENEURO
• 影响因子: 3.4
• 作者: Yoshikawa, Tomoko;Pauls, Scott;Silver, Rae
• 通讯作者: Silver, Rae

Arginine Vasopressin-Containing Neurons of the Suprachiasmatic Nucleus Project to CSF

视交叉上核中含有精氨酸加压素的神经元投射到脑脊液

• DOI: 10.1523/eneuro.0363-20.2021
• 发表时间: 2021
• 期刊: eneuro
• 影响因子: 3.4
• 作者: Taub, Alana;Carbajal, Yvette;Rimu, Kania;Holt, Rebecca;Yao, Yifan;Hernandez, Amanda L.;LeSauter, Joseph;Silver, Rae
• 通讯作者: Silver, Rae