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MRI: Acquisition of a confocal microscope to enhance biological and materials research at Montana Tech

MRI：购买共焦显微镜以加强蒙大拿理工大学的生物和材料研究

基本信息

批准号：
1828523
负责人：
Katherine Zodrow
金额：
$ 36.44万
依托单位：
Montana Technological University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2021-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828523&HistoricalAwards=false
关键词：
MRI Acquisition confocal microscope enhance

项目摘要

A confocal microscope is a powerful instrument that will enhance research and educational opportunities at Montana Tech, a rural, primarily undergraduate institution (PUI) in southwest Montana. Confocal microscopy enables quantitative characterization of samples across various fields, including biological, environmental, and materials. At Montana Tech, 12 research users were identified, along with two users at Salish Kootneai College (SKC), a nearby tribal college that will benefit from the microscope's remote access capabilities. The microscope will be used by at least 25 graduate students, and 20 undergraduate students for research projects in the first year, and it will be included in the curriculum of five courses (including courses at SKC and University of Montana Western), introducing approximately 100 students to confocal fluorescent microscopy. Additionally, the microscope will be available to industrial users through an agreement with Alpha Technology, LLC, and it will be used in a collaboration with the Imagine Butte Resource Center, a local art collective. The proposed Leica SP8 confocal system is configured for maximum versatility and ease of use, given the needs of researchers and instructors at Montana Tech. It includes an upright configuration that enables easy visualization of biofilm samples, four laser lines necessary for excitation of fluorophores commonly used in the biological and environmental sciences, multiple detectors for simultaneous acquisition of different excited fluorophores, and a high definition detector necessary for live-cell work. The instrument will be used in a variety of projects, including examining the impact of biofilms on metals transport in mine waste-impacted streams, the adaptation of alpine plants in response to changes in climate, biofilm formation and treatment in water treatment systems, biofilm-assisted nitrate reduction, and the production of nanocomposite wound dressings and tissue scaffolds. Overall, the addition of a confocal microscope to the suite of analytical instruments at Montana Tech will increase research capacity and enhance education at a rural PUI, enable access to advanced instrumentation by a nearby tribal college, facilitate collaborations with industry, and promote science educational outreach.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

共焦显微镜是一种强大的仪器，将增加蒙大拿理工学院的研究和教育机会，蒙大拿理工学院是蒙大拿州西南部的一所农村本科院校 (PUI)。共焦显微镜可以对各个领域的样品进行定量表征，包括生物、环境和材料。在蒙大拿理工学院，确定了 12 名研究用户，以及萨利什库特尼艾学院 (SKC) 的两名用户，该学院是附近的一所部落学院，将受益于显微镜的远程访问功能。第一年至少将有 25 名研究生和 20 名本科生使用该显微镜进行研究项目，并将纳入 5 门课程（包括 SKC 和蒙大拿大学西部分校的课程）的课程中，向约 100 名学生介绍共焦荧光显微镜。此外，该显微镜将通过与 Alpha Technology, LLC 的协议向工业用户提供，并将与当地艺术团体 Imagine Butte 资源中心合作使用。考虑到蒙大拿理工学院研究人员和讲师的需求，拟议的 Leica SP8 共焦系统经过配置，可实现最大的多功能性和易用性。它包括可轻松可视化生物膜样品的直立配置、激发生物和环境科学中常用荧光团所需的四根激光线、用于同时采集不同激发荧光团的多个检测器以及活细胞工作所需的高清检测器。该仪器将用于各种项目，包括检查生物膜对受矿山废物影响的溪流中金属运输的影响、高山植物对气候变化的适应、水处理系统中生物膜的形成和处理、生物膜辅助硝酸盐还原以及纳米复合伤口敷料和组织支架的生产。总体而言，在蒙大拿理工学院的分析仪器套件中添加共焦显微镜将提高农村 PUI 的研究能力并加强教育，使附近的部落学院能够获得先进的仪器，促进与行业的合作，并促进科学教育的推广。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。