MRI: Acquisition of two photon spatial light modulation microscope for all optical reading and writing into tissues

MRI：获取两个光子空间光调制显微镜，用于组织中的所有光学读取和写入

• 批准号: 1828647
• 负责人: Fidel Santamaria
• 金额: $ 56.96万
• 依托单位: University of Texas at San Antonio
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828647&HistoricalAwards=false
• 关键词: MRI; Acquisition; two; photon; spatial

An award is made to the University of Texas at San Antonio (UTSA) to establish microscopy infrastructure that will enhance investigator research in biomedicine, physics, neuroscience, and molecular biology. The instrument will expand research capacity at UTSA by introducing "closed-loop" experimentation on live cell/tissue samples. This will allow researchers to simultaneously optically acquire and manipulate precise spatiotemporal signals in real-time. In addition to research enhancement, the asset will serve student training with a program of workshops in technical mastery and cross-discipline science communication. Students from participating laboratories will develop proficiency in lay and specialized explanations of the technology, protocols, applications, and results obtained from their research. A compilation of student produced and narrated computer presentations and training videos will be made available to the lay public, and incorporated into student-curated Wikipedia pages as part of a public-science literacy outreach initiative.The shared goal among the diverse users of the microscope is to acquire or "read" the activity of cells that are embedded in a complex network while "writing in" stimuli in cellular or sub-cellular compartments. The microscope's revolutionary technology allows delivery of precise three-dimensional spatio-temporal patterns of light. This unique capability will allow researchers to measure input-output transfer functions of complex cellular networks and address an expansive range of scientific questions not previously possible. The equipment design will be flexible, in order to accommodate preparations from tissues, whole animals, and plants. The microscopy unit will enhance research rigor and become a nucleus for multi-disciplinary collaboration, and will transform the research and training landscape of UTSA.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

向得克萨斯大学圣安东尼奥分校（UTSA）颁发了奖励，以建立显微镜基础设施，以增强研究人员在生物医学，物理，神经科学和分子生物学方面的研究。该仪器将通过对活细胞/组织样品进行“闭环”实验来扩大UTSA的研究能力。这将使研究人员可以实时光学地获取并操纵精确的时空信号。除了研究增强外，资产还将通过技术精通和跨学科科学通讯的研讨会来为学生培训提供培训。 来自参与实验室的学生将提高对技术，协议，应用程序以及从其研究中获得的结果的专业解释的熟练程度。 A compilation of student produced and narrated computer presentations and training videos will be made available to the lay public, and incorporated into student-curated Wikipedia pages as part of a public-science literacy outreach initiative.The shared goal among the diverse users of the microscope is to acquire or "read" the activity of cells that are embedded in a complex network while "writing in" stimuli in cellular or sub-cellular compartments.显微镜的革命性技术允许提供精确的三维时空图案的光。这种独特的功能将使研究人员能够测量复杂的蜂窝网络的输入输出传输函数，并解决以前无法使用的广泛科学问题。设备设计将是灵活的，以适应组织，整个动物和植物的制剂。显微镜单元将增强研究的严格性并成为多学科合作的核心，并将改变UTSA的研究和培训格局。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的智力优点和更广泛的影响评估的评估来通过评估来支持的。