MRI: Acquisition of Confocal and Two-Photon Excitation Microscope

MRI：共焦和双光子激发显微镜的采集

• 批准号: 1337774
• 负责人: Brett Tyler
• 金额: $ 56.07万
• 依托单位: Oregon State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1337774&HistoricalAwards=false
• 关键词: MRI; Acquisition; Confocal; Two; Photon

An award is made to Oregon State University to purchase a confocal and two photon microscope system for life science research, education and training. Combined with the rapid increase in genomic information, confocal and two photon microscopy provides an unparalleled ability to identify the cellular components of living organisms, and to determine their functions. Key new features of this microscope include: two photon excitation for deep tissue imaging, and preservation of live organisms and cells; a tunable TiSa laser; 34 spectral detection channels; and high sensitivity GaAsP detectors for faster acquisition and dynamic imaging. Research and training programs of over 38 faculty in 12 departments and centers and 7 colleges will be strengthened and transformed by the novel capabilities of the new instrument. The research will advance knowledge of plants, animals, microbes, pathogens, symbionts and communities, in natural, managed, healthy and polluted environments, spanning agricultural, forest, ocean, and human ecosystems.The novel capabilities of the two photon and confocal microscope, will advance solutions to the most complex challenges facing mankind including environmental health, ecosystem loss, sustainable food and energy production, infectious disease, and understanding behavior and the mind. A new undergraduate learning and research program on biological imaging will be enabled by the microscope acquisition and will provide students with the tools to understand and apply microscopy and imaging techniques, engage in inquiry-based research, conduct ethical and appropriate scientific methods. The interdepartmental Ph.D. program in Molecular and Cellular Biology program will be strengthened by the access provided students to cutting edge imaging technology. Access to this technology would benefit the broader Oregon research community, including small regional companies.

授予俄勒冈州州立大学一个奖项，购买一个共焦和双光子显微镜系统，用于生命科学研究、教育和培训。结合基因组信息的快速增长，共聚焦和双光子显微镜提供了无与伦比的能力来识别活生物体的细胞成分，并确定其功能。该显微镜的主要新功能包括：用于深层组织成像的双光子激发，以及活生物体和细胞的保存;可调谐TiSa激光器; 34个光谱检测通道;以及用于更快采集和动态成像的高灵敏度GaAsP探测器。12个部门和中心以及7所学院的38多名教师的研究和培训计划将通过新仪器的新功能得到加强和转变。该研究将推进对自然、管理、健康和污染环境中的植物、动物、微生物、病原体、共生体和群落的认识，涵盖农业、森林、海洋和人类生态系统。双光子和共聚焦显微镜的新功能将推进人类面临的最复杂挑战的解决方案，包括环境健康、生态系统损失、可持续粮食和能源生产、传染病，以及理解行为和思想。一个新的本科生学习和生物成像研究计划将通过显微镜收购启用，并将为学生提供工具来理解和应用显微镜和成像技术，从事基于探究的研究，进行道德和适当的科学方法。跨部门的博士学位分子和细胞生物学课程将通过为学生提供尖端成像技术来加强。获得这项技术将有利于更广泛的俄勒冈州研究界，包括小型地区公司。