MRI: Acquisition of a micro-CT for broad integrative biology use and building resources towards the Imaging Center of the Pacific

授予夏威夷大学M&amp；#0257noa购买微型计算机断层扫描(&amp；#0181CT)仪器。这种类型的仪器已经成为基础研究中的一项重要和广泛使用的技术，因为它能够对广泛的组织产生快速、可重复的、非破坏性的三维成像。新的CT系统将显著增强广泛的地方研究项目，使研究人员能够启动、继续和扩大珊瑚、昆虫和软体动物的分类学、节肢动物和鱼类的感官系统进化、青蛙和海蜘蛛的形态和生理以及海洋酸化对珊瑚的影响等方面的研究。这种新的成像仪器将向校园内的生命科学研究人员以及研究生和本科生开放，促进年轻科学家接受先进3D成像技术的培训。通过与夏威夷大学和火奴鲁鲁伯尼斯波阿希主教博物馆的用户合作，PI和共同PI将建立一个夏威夷本土生物多样性3D模型的虚拟博物馆，公众和世界各地的研究人员都可以在线访问。这些对本土动物的3D扫描也将被用于为毕晓普博物馆的生物多样性展品创建大规模的3D模型。新的CT成像系统将被添加到夏威夷大学高级生物成像研究中心(CABR)，以开发一个全面的、多模式的研究设施，为当地夏威夷人和更广泛的太平洋地区的研究社区服务。该仪器的位置使研究人员能够在岛屿生物多样性的主要热点之一获得快速、负担得起、易于使用的非侵入性成像技术，从而能够研究在夏威夷发现的独特、特有和迅速衰落的动物。新仪器将支持硬组织和软组织成像的3D显微镜，能够绘制活动物的基因组-表现组相互作用、生理、新陈代谢和分子相互作用图，并加强基于地点的研究。新仪器建立在华盛顿大学管理部门最初在成像技术上的强大投资基础上，并将支持跨学科研究、教育和培训。通过向夏威夷大学的成像资源添加CT成像系统而产生的多模式能力，将使其在全国生物成像设施中独树一帜，因为它允许从事基础科学的研究人员和学生访问。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the University of Hawai'i at M&#0257noa to purchase a micro-computed tomography (&#0181CT) instrument. This type of instrument has become an important and widely-used used technology in basic research due to its ability to generate fast, reproducible, non-destructive 3-D imaging of a broad range of tissues. The new &#0181CT system will significantly enhance a broad spectrum of local research programs, enabling researchers to initiate, continue, and expand studies of taxonomy in corals, insects and mollusks; sensory system evolution in arthropods and fish; morphology and physiology in frogs and sea spiders; and the impacts of ocean acidification on corals, among many others. This new imaging instrument will be accessible to life science researchers across campus, as well as graduate and undergraduate students, promoting the training of young scientists in advanced 3D imaging technologies. By partnering with &#0181CT users from both the University of Hawai'i and the Bernice Pauahi Bishop Museum in Honolulu, the PI and co-PI will build a Virtual Museum of 3D models of native Hawaiian biodiversity that will be accessible online to the general public and to researchers around the world. These 3D scans of native fauna will also be used to create large scale, 3D models for biodiversity exhibits at the Bishop Museum. The new &#0181CT imaging system will be added to the University of Hawai'i at M&#0257noa Center of Advanced Bioimaging Research (CABR) to develop a comprehensive, multi-modality research facility that will serve the local Hawaiian, and broader Pacific, research community. The location of the instrument affords researchers access to fast, affordable, easy-to-use, non-invasive imaging techniques in one of the premier hotspots of island biodiversity, allowing for studies of the unique, endemic, and rapidly declining fauna found in Hawai'i. The new instrument will support 3D microscopy of hard and soft tissue imaging, capable of mapping genome-phenome interactions, physiology, metabolism, and molecular interactions in living animals, and enhancing efforts to conduct place-based research. The new instrumentation builds on the initial strong investment by UH administration in imaging technology and will support interdisciplinary research, education, and training. The multimodality capability created by the addition of a &#0181CT imaging system to the University of Hawai'i imaging resources will make it unique among bioimaging facilities across the nation because of the access afforded to researchers and students engaged in basic science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.