Dimensions: Eco-Evolutionary Drivers of Diversity in Toxic Algal Blooms

维度：有毒藻华多样性的生态进化驱动因素

• 批准号: 1831493
• 负责人: Jennifer Wisecaver
• 金额: $ 199.92万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1831493&HistoricalAwards=false
• 关键词: Dimensions; Eco; Evolutionary; Drivers; Diversity

Ecology and evolution are two significant biological processes that are often studied independently. Yet, it is likely that interactions between ecology and evolution are key to generating biological diversity. This project will study toxic algal blooms to understand how links between ecological and evolutionary processes shape biodiversity. The last decade has seen amazing advances in genome sequencing technology and biological data analysis. There is now an opportunity to apply this new technology to the study of algae. Algae are important for several reasons. Algae are the primary producers in most ocean and freshwater environments. Algae produce numerous substances including antibiotics and other potential human drugs. Algae also produce toxins that endanger human health and water quality. These toxic algal blooms are increasing in both frequency and severity across the globe. The resources developed as a result of this project will help better predict toxic algal blooms. This project will train undergraduate students in genomics and phylogenetic approaches. Outreach materials focused on the algae in aquarium habitats will also be developed for the Biosphere 2 facility in Arizona.The goal of this research is to study a type of toxic alga called Prymnesium. Prymnesium is abundant in aquatic communities in Texas. The project will focus on study sites in Texas. The project will test the hypothesis that changes in toxicity shape the genetic diversity of Prymnesium populations. To do so, the project will first characterize the diversity of toxic algal blooms through whole genome sequencing of over 100 diverse Prymnesium strains. This will be the largest survey of genomic variation within a natural algal population to date. Second, the project will identify the molecular mechanisms of toxicity using RNA sequencing and network analysis. This approach will overcome the challenge of rapid, accurate identification of genes underlying functional traits. Third, the researchers will integrate the empirical data into mathematical models of eco-evolutionary feedbacks to predict all three dimensions (genetic, phylogenetic, and function) of biodiversity within toxic algal blooms.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生态学和进化是两个重要的生物学过程，通常被独立研究。然而，生态学和进化之间的相互作用可能是产生生物多样性的关键。该项目将研究有毒藻华，以了解生态和进化过程之间的联系如何塑造生物多样性。在过去的十年里，基因组测序技术和生物数据分析取得了惊人的进步。现在有机会将这项新技术应用于藻类的研究。藻类之所以重要有几个原因。藻类是大多数海洋和淡水环境中的初级生产者。藻类产生许多物质，包括抗生素和其他潜在的人类药物。藻类还产生危害人类健康和水质的毒素。这些有毒藻华在全球范围内的频率和严重程度都在增加。地球仪。该项目开发的资源将有助于更好地预测有毒藻华。本计画将训练本科生学习基因组学与系统发育方法。针对水族馆栖息地藻类的宣传材料也将为亚利桑那州的生物圈2号设施开发。这项研究的目标是研究一种名为Prymnesium的有毒藻类。Prymnesium在德克萨斯州的水生群落中很丰富。该项目将集中在德克萨斯州的研究地点。该项目将测试毒性变化塑造Prymnesium种群遗传多样性的假设。为此，该项目将首先通过对100多个不同的Prymnesium菌株进行全基因组测序来确定有毒藻华的多样性。这将是迄今为止对天然藻类种群中基因组变异的最大调查。其次，该项目将使用RNA测序和网络分析来确定毒性的分子机制。这种方法将克服快速，准确识别功能性状基因的挑战。第三，研究人员将把经验数据整合到生态进化反馈的数学模型中，以预测有毒藻华中生物多样性的所有三个维度（遗传、系统发育和功能）。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

CHD Chromatin Remodeling Protein Diversification Yields Novel Clades and Domains Absent in Classic Model Organisms.

• DOI: 10.1093/gbe/evac066
• 发表时间: 2022-05-03
• 期刊: GENOME BIOLOGY AND EVOLUTION
• 影响因子: 3.3
• 作者: Trujillo, Joshua T.;Long, Jiaxin;Aboelnour, Erin;Ogas, Joseph;Wisecaver, Jennifer H.
• 通讯作者: Wisecaver, Jennifer H.

Hybrid de novo genome assembly of red gromwell (Lithospermum erythrorhizon) reveals evolutionary insight into shikonin biosynthesis

• DOI: 10.1038/s41438-020-0301-9
• 发表时间: 2020-06-01
• 期刊: HORTICULTURE RESEARCH
• 影响因子: 8.7
• 作者: Auber, Robert P.;Suttiyut, Thiti;Wisecaver, Jennifer H.
• 通讯作者: Wisecaver, Jennifer H.

Behavioural differences underlie toxicity and predation variation in blooms of Prymnesium parvum

行为差异是小金藻水华毒性和捕食变异的基础

• DOI: 10.1111/ele.14172
• 发表时间: 2023
• 期刊: Ecology Letters
• 影响因子: 8.8
• 作者: Driscoll, William W.;Wisecaver, Jennifer H.;Hackett, Jeremiah D.;Espinosa, Noelle J.;Padway, Jared;Engers, Jessica E.;Bower, Jessica A.
• 通讯作者: Bower, Jessica A.