The effect of age on regulatory T cell control of the innate and adaptive antiviral immune responses

病毒病原体是世界上婴儿死亡的主要原因。 该项目将定义T调节细胞如何限制年轻人的保护性抗病毒免疫反应。这一信息对于开发从新生儿期起有效而不诱导自身免疫的强效抗病毒疫苗至关重要。它还将为T调节细胞的操纵方式提供新的见解，以抑制免疫力，这可用于制定减少免疫介导的疾病和限制移植排斥反应的策略。

Viral pathogens are a lead cause of infant mortality in the world. This project will define how T regulatory cells limit protective antiviral immune responses in the young. This information is critical for the development of potent antiviral vaccines that are effective from the newborn period without inducing autoimmunity. It will also provide novel insight into the way T regulatory cells can be manipulated both to dampen immunity, which can be used to develop strategies to reduce immune mediated disease and limit transplant rejection.