The effect of age on regulatory T cell control of the innate and adaptive antiviral immune responses

年龄对调节性 T 细胞控制先天性和适应性抗病毒免疫反应的影响

• 批准号: DP0877733
• 负责人: Prof Cheryl Jones
• 金额: $ 22.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-07-24 至 2011-07-24
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877733
• 关键词: effect; age; regulatory; cell; control

Viral pathogens are a lead cause of infant mortality in the world. This project will define how T regulatory cells limit protective antiviral immune responses in the young. This information is critical for the development of potent antiviral vaccines that are effective from the newborn period without inducing autoimmunity. It will also provide novel insight into the way T regulatory cells can be manipulated both to dampen immunity, which can be used to develop strategies to reduce immune mediated disease and limit transplant rejection.

病毒病原体是世界上婴儿死亡的主要原因。 该项目将定义 T 调​​节细胞如何限制年轻人的保护性抗病毒免疫反应。这些信息对于开发有效的抗病毒疫苗至关重要，这些疫苗从新生儿期起就有效，且不会诱发自身免疫。它还将为如何操纵 T 调节细胞来抑制免疫提供新的见解，这可用于制定减少免疫介导的疾病和限制移植排斥的策略。