Defining the contribution of skin gamma delta T cells to cutaneous immunosurveillance, immunity and disease after HSV infection.

定义皮肤 γ δ T 细胞对 HSV 感染后皮肤免疫监视、免疫和疾病的贡献。

• 批准号: nhmrc : 1023250
• 负责人: Prof Cheryl Jones
• 金额: $ 40.1万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-contribution-skin-hsv-infection/110260
• 关键词: Defining; contribution; skin; gamma; delta

Herpes simplex virus (HSV) causes genital herpes and encephalitis. Disease is severe in the immunocompromised and the newborn. HSV enters through breaks in the skin or mucosa, where it first encounters gamma delta T cells. We have recently made the key finding that HSV can infect gamma delta T-cells shortly after inoculation. Here we will study how they contribute to the immune response when a virus enters the skin in mice and human tissues. This may lead development of new topical antiviral vaccines.

单纯疱疹病毒（HSV）引起生殖器疱疹和脑炎。免疫功能低下者和新生儿的疾病很严重。 HSV 通过皮肤或粘膜的破损处进入，首先在那里遇到 γ δ T 细胞。我们最近取得了重要发现，HSV 可以在接种后不久感染 γ δ T 细胞。在这里，我们将研究当病毒进入小鼠皮肤和人体组织时它们如何促进免疫反应。这可能会导致新的局部抗病毒疫苗的开发。