Defining the dynamics and function of dendritic cells after cutaneous HSV infection in vivo.

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Herpes simplex viral causes infections of the skin, eye, brain, genitals and of the newborn. HSV enters via breaks in the skin where it encounters dendritic cells, which are important for local control of the virus locally and for T cell responses. We will use two photon microscopy to visualise fluorescent HSV in mice in which DC appear green under the microscope. This will help us understand the interaction between HSV and DC in vivo which will aid design of topical antivirals and vaccines.