Defining the dynamics and function of dendritic cells after cutaneous HSV infection in vivo.

定义体内皮肤 HSV 感染后树突状细胞的动力学和功能。

• 批准号: nhmrc : 570742
• 负责人: Prof Cheryl Jones
• 金额: $ 27.95万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-dynamics-function-infection-vivo/82098
• 关键词: Defining; dynamics; function; dendritic; cells

Herpes simplex viral causes infections of the skin, eye, brain, genitals and of the newborn. HSV enters via breaks in the skin where it encounters dendritic cells, which are important for local control of the virus locally and for T cell responses. We will use two photon microscopy to visualise fluorescent HSV in mice in which DC appear green under the microscope. This will help us understand the interaction between HSV and DC in vivo which will aid design of topical antivirals and vaccines.

单纯疱疹病毒引起皮肤、眼睛、大脑、生殖器和新生儿感染。 HSV 通过皮肤破损处进入，并在那里遇到树突状细胞，这对于局部控制病毒和 T 细胞反应非常重要。我们将使用两个光子显微镜来观察小鼠中的荧光 HSV，其中 DC 在显微镜下呈绿色。这将有助于我们了解体内 HSV 和 DC 之间的相互作用，从而有助于设计局部抗病毒药物和疫苗。