The Phylodynamics of Human Enteroviruses: Informing Vaccine Effectiveness and Outbreak Preparedness

人类肠道病毒的系统动力学：告知疫苗有效性和疫情爆发准备

• 批准号: nhmrc : GNT1099618
• 负责人: Prof Cheryl Jones
• 金额: $ 56.49万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phylodynamics-human-enteroviruses-outbreak-preparedness/1346072
• 关键词: Phylodynamics; Human; Enteroviruses; Informing; Vaccine

Enteroviruses such as EV-A71 are increasing in frequency and in Australia have resulted in the hospitalization of children with severe encephalitis. However, major aspects of their evolution and epidemiology are unknown. We will provide new insights on these important pathogens by revealing which enteroviruses are circulating in the region and whether they arise in specific localities, whether some are commonly associated with severe encephalitis, and whether some pose a greater epidemic threat.

EV-A71等肠道病毒的感染频率正在增加，在澳大利亚已导致患有严重脑炎的儿童住院治疗。然而，它们的进化和流行病学的主要方面是未知的。我们将通过揭示哪些肠道病毒在该地区流行，它们是否出现在特定地区，一些是否通常与严重脑炎有关，以及一些是否构成更大的流行病威胁，对这些重要病原体提供新的见解。