IIBR RoL: Collaborative Research: A Rules Of Life Engine (RoLE) Model to Uncover Fundamental Processes Governing Biodiversity

IIBR RoL：协作研究：揭示生物多样性基本过程的生命规则引擎 (RoLE) 模型

• 批准号: 2104147
• 负责人: Andrew Rominger
• 金额: $ 39.81万
• 依托单位: University of Maine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-15 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2104147&HistoricalAwards=false
• 关键词: IIBR; RoL; Collaborative; Research; Rules

An unprecedented opportunity to advance understanding of the biological rules that govern the diversity and dynamics of life now exists thanks to the large quantity and variety of data that are becoming increasingly available. This goal of understanding biodiversity dynamics is enabled at a critical moment when human systems are disrupting those very dynamics. However, the scientific and computational tools needed to derive understanding from data are still missing. Such tools need to be accessible to a broad community of users, thereby catalyzing involvement and innovation. This project will (1) build a computational model for multiple aspects of biodiversity-species abundance, genetic, functional, and phylogenetic; (2) use and refine this model by testing major hypotheses about the generation and maintenance of biodiversity in three exemplar systems; (3) make the model accessible to the scientific community by building an open-source platform to prepare diverse data sources and run the model; and (4) create pedagogically effective courses and workshops to enable students, researchers, and stakeholders from many backgrounds to understand biodiversity theory and the data science tools needed to test those theories with data.The Rules of Life Engine (RoLE) model will be a mechanistic, simulation-based hypothesis-testing and data synthesis framework enabling scientists with multi-dimensional biodiversity data to generate and test hypotheses about the processes driving biodiversity patterns. The RoLE model will apply new techniques in machine learning to fit models to high dimensional, cross-scale data. The model will simulate eco-evolutionary community assembly building from individual-based ecological and genetic neutral models with added non-neutral, trait-based competition and environmental filtering. New species and traits will arise through long time scale evolution in the meta-community and rapid evolution in the local community. Population genetics and species abundances in the local community will be modeled through birth, death, immigration, and mutation. The project research team will refine and illustrate the use of the RoLE model by testing four hypothesized rules of life across three bio-geographic systems for which multi-scale biodiversity data are now available. The hypotheses address the relative roles of immigration versus speciation in community assembly, how species interactions influence diversity, how different assembly histories determine the strength of species interactions, and whether/how systems come to equilibrium. The project leaders have established a network of 14 collaborators, including the National Ecological Observatory Network, who will use the RoLE model in their diverse systems and propagate wider adoption. In order to further reduce barriers to use, the RoLE model framework will be made available as open source software, including an R language Shiny App interface with standardized metadata outputs to promote reproducibility and sharing. The insights gained from the RoLE model are of direct relevance to conservation, e.g., whether or not communities are assembled primarily by speciation or immigration strongly determines their response to anthropogenic pressures and optimal conservation management. To encourage participation in quantitative biodiversity research, the project leaders will develop a massively open online course through the Santa Fe Institute?s Complexity Explorer program using the RoLE model as an interactive teaching tool. In conjunction with Data Carpentry and Software Carpentry, the research team will also provide an in-person data science training workshop. Results from the RoLE project can be found at https://role-model.github.io.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

由于越来越多的数据变得越来越多，现在有了一个前所未有的机会来促进对支配生命多样性和动态的生物规则的理解。这个了解生物多样性动态的目标是在人类系统正在破坏这些动态的关键时刻实现的。然而，从数据中获得理解所需的科学和计算工具仍然缺乏。这样的工具需要为广大用户社区所用，从而促进参与和创新。该项目将(1)为生物多样性的多个方面--物种丰度、遗传、功能和系统发育--建立一个计算模型；(2)通过在三个样本系统中检验关于生物多样性生成和维持的主要假设来使用和改进该模型；(3)通过建立一个开放源码平台来准备不同的数据源并运行该模型，从而使该模型可供科学界使用；以及(4)创建教学有效的课程和工作坊，使来自不同背景的学生、研究人员和利益相关者能够了解生物多样性理论以及用数据测试这些理论所需的数据科学工具。生命引擎规则(Role)模型将是一个基于模拟的假设检验和数据合成框架，使拥有多维生物多样性数据的科学家能够生成和测试关于驱动生物多样性格局的过程的假设。角色模型将应用机器学习中的新技术，使模型适应高维、跨尺度的数据。该模型将从基于个体的生态和遗传中性模型出发，通过添加非中性、基于特征的竞争和环境过滤来模拟生态进化社区的组装构建。新的物种和性状将通过元群落的长期规模进化和局部群落的快速进化而产生。当地社区的种群遗传学和物种丰富度将通过出生、死亡、移民和突变来模拟。该项目研究小组将通过测试三个生物地理系统的四个假设的生命规则来完善和说明角色模型的使用，目前已有多尺度生物多样性数据可供使用。这些假说解决了移民和物种形成在群落组装中的相对作用，物种相互作用如何影响多样性，不同的组装历史如何决定物种相互作用的强度，以及系统是否/如何达到平衡。项目负责人已经建立了一个由14名合作者组成的网络，其中包括国家生态观测网络，这些合作者将在他们的不同系统中使用榜样，并推广更广泛的采用。为了进一步减少使用障碍，榜样框架将作为开放源码软件提供，包括R语言闪亮的App界面，具有标准化的元数据输出，以促进可重复性和共享性。从榜样中获得的见解与保护直接相关，例如，群落是否主要由物种形成或移民组成，这在很大程度上决定了它们对人为压力的反应和最佳保护管理。为了鼓励参与定量的生物多样性研究，项目负责人将通过圣达菲研究所-S复杂性探索者项目开发一个大规模开放的在线课程，使用榜样作为互动教学工具。研究团队还将与数据木工和软件木工合作，提供面对面的数据科学培训工作坊。角色项目的结果可以在https://role-model.github.io.This奖项中找到，该奖项反映了国家科学基金会的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

High-throughput sequencing for community analysis: the promise of DNA barcoding to uncover diversity, relatedness, abundances and interactions in spider communities

• DOI: 10.1007/s00427-020-00652-x
• 发表时间: 2020-02-10
• 期刊: DEVELOPMENT GENES AND EVOLUTION
• 影响因子: 2.4
• 作者: Kennedy, Susan R.;Prost, Stefan;Krehenwinkel, Henrik
• 通讯作者: Krehenwinkel, Henrik

Editorial: Ecological Non-equilibrium in the Anthropocene

社论：人类世的生态非平衡

• DOI: 10.3389/fevo.2019.00428
• 发表时间: 2019
• 期刊: Frontiers in Ecology and Evolution
• 影响因子: 3
• 作者: Rapacciuolo, Giovanni;Rominger, Andrew J.;Morueta-Holme, Naia;Blois, Jessica L.
• 通讯作者: Blois, Jessica L.

Multiple paths toward repeated phenotypic evolution in the spiny‐leg adaptive radiation ( Tetragnatha ; Hawai'i)

刺腿适应性辐射中重复表型进化的多种途径（Tetragnatha；夏威夷）

• DOI: 10.1111/mec.17082
• 发表时间: 2023
• 期刊: Molecular Ecology
• 影响因子: 4.9
• 作者: Cerca, José;Cotoras, Darko D.;Santander, Cindy G.;Bieker, Vanessa C.;Hutchins, Leke;Morin‐Lagos, Jaime;Prada, Carlos F.;Kennedy, Susan;Krehenwinkel, Henrik;Rominger, Andrew J.
• 通讯作者: Rominger, Andrew J.

Unifying macroecology and macroevolution to answer fundamental questions about biodiversity

统一宏观生态学和宏观进化来回答有关生物多样性的基本问题

• DOI: 10.1111/geb.13020
• 发表时间: 2019
• 期刊: Global Ecology and Biogeography
• 影响因子: 6.4
• 作者: McGill, Brian J.;Chase, Jonathan M.;Hortal, Joaquín;Overcast, Isaac;Rominger, Andrew J.;Rosindell, James;Borges, Paulo A. V.;Emerson, Brent C.;Etienne, Rampal S.;Hickerson, Michael J.
• 通讯作者: Hickerson, Michael J.