CAREER: Instrument Development of Plasmonic-Assisted Nanomechanical Detection for Polarized Spectroscopy and Imaging

职业：用于偏振光谱和成像的等离子体辅助纳米机械检测仪器的开发

• 批准号: 1847830
• 负责人: Laurene Tetard
• 金额: $ 40.4万
• 依托单位: The University of Central Florida Board of Trustees
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2025-01-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1847830&HistoricalAwards=false
• 关键词: CAREER; Instrument; Development; Plasmonic; Assisted

With this project, supported by the Chemical Measurement and Imaging program in the Chemistry Division, Professor Laurene Tetard and her students in the Department of Physics and the NanoScience Technology Center at the University of Central Florida are studying important molecular structures of living systems at the nanoscale. Using polarized infrared light to enhance the capabilities of a method known as Atomic Force Microscopy (AFM), the Tetard group is able to observe the chemical and structural properties of single molecules and their assemblies. The new approach can evaluate the orientations and crystallinity of systems which cannot be studied with conventional tools, enabling deeper understanding of important processes in chemistry, food science, catalysis, environmental science, forensics, and biology. The team is also generating educational materials to communicate the concepts and relevance of its research activities through a series of workshops offering hands-on and project-based activities. A diverse group of students is engaged in the conception and execution of the workshops, with an aim of inspiring participants (including women and underrepresented minority students) to pursue careers in STEM. Living systems and their components, such as nucleic and amino acids, can present complex structural arrangements, such as chirality. Despite the important relationship between the structure and function of these unique self-assembled structures, standard analytical tools are deficient in probing low concentration, single molecular processes or rare events. Dr. Tetard is developing and evaluating a new approach to nanoscale polarized infrared spectroscopy to enable identification of molecular chirality in complex systems, and to further establish means to monitor specific dynamic structure-activity relationships associated with these systems. The approach utilizes light polarization and field enhancement for nanomechanical AFM detection. The performance of the platform is being tested on several molecules of importance in life sciences. Additional efforts target time-resolved monitoring of changes in molecular twists. The educational component involves developments at the forefront of nanoscale science in rich project-based activities for a series of workshops in the US and abroad. Resulting hands-on and project-based activities will be made publicly available for teaching laboratories.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量和成像计划的支持下，Laurene Tetard教授和她在中佛罗里达大学物理系和纳米科学技术中心的学生们正在纳米尺度上研究生命系统的重要分子结构。使用偏振红外光来增强原子力显微镜(AFM)的能力，Tetard团队能够观察单个分子及其组件的化学和结构属性。这种新的方法可以评估用传统工具无法研究的体系的取向和结晶度，使人们能够更深入地了解化学、食品科学、催化、环境科学、法医学和生物学中的重要过程。该小组还正在编写教育材料，通过一系列讲习班交流其研究活动的概念和相关性，这些讲习班提供实际操作和基于项目的活动。一个不同的学生群体参与了讲习班的构思和实施，目的是激励参与者(包括妇女和代表不足的少数族裔学生)在STEM追求职业生涯。生命系统及其组成部分，如核酸和氨基酸，可以呈现复杂的结构排列，如手性。尽管这些独特的自组装结构的结构和功能之间存在着重要的关系，但标准的分析工具在探测低浓度、单分子过程或罕见事件方面存在不足。泰达德博士正在开发和评估一种新的纳米级偏振红外光谱方法，以识别复杂系统中的分子手性，并进一步建立监测与这些系统相关的特定动态结构-活性关系的方法。该方法利用光的偏振和场增强来检测纳米机械原子力显微镜。该平台的性能正在生命科学中的几个重要分子上进行测试。其他努力的目标是对分子扭曲变化进行时间分辨监测。教育部分涉及在美国和国外举办的一系列研讨会的丰富的基于项目的活动中纳米科学前沿的发展。由此产生的实践活动和基于项目的活动将公开提供给教学实验室。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Acoustic subsurface-atomic force microscopy: Three-dimensional imaging at the nanoscale

• DOI: 10.1063/5.0035151
• 发表时间: 2021-01
• 期刊: Journal of Applied Physics
• 影响因子: 3.2
• 作者: H. J. Sharahi;M. Janmaleki;L. Tetard;Seonghwan Kim;H. Sadeghian;G. Verbiest

Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

纳米级红外光谱学的进展探索多相聚合物系统

• DOI: 10.3791/65357
• 发表时间: 2023
• 期刊: Journal of Visualized Experiments
• 作者: Young, Rebecca;Tetard, Laurene
• 通讯作者: Tetard, Laurene