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CAREER: Advancing Ion Concentration Polarization to Enrich New Classes of Analytes from Complex Media and to Interface with Analysis: Breaking the Glass Ceiling on Enrichment

职业：推进离子浓度偏振以从复杂介质中富集新类型的分析物并与分析相结合：打破富集的玻璃天花板

基本信息

批准号：
1849109
负责人：
Robbyn Anand
金额：
$ 62万
依托单位：
Iowa State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2024-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1849109&HistoricalAwards=false
关键词：
CAREER Advancing Ion Concentration Polarization

项目摘要

Professor Robbyn Anand of Iowa State University is supported by the Chemical Measurement and Imaging Program of the Division of Chemistry to develop analytical techniques that address current limitations to the selective separation and enrichment of chemical compounds from difficult to handle fluids. The newly developed technique sensitively detects the separated compounds at the site of enrichment. The focus is on currently inaccessible categories of compounds, including medications, food additives, and clinically-relevant targets present in biological fluids, food, and pharmaceutical formulations. The project positively impacts society by improving public health through more accurate medical diagnostics and the assurance of high quality food and medications. The project supports the development of a workshop-style college course to promote diversity in science by engaging students in discussions on topics such as work-life balance, workplace climate, entrepreneurship, and networking. In addition, case studies are developed to improve learning outcomes in graduate-level electrochemistry educational material. The project tackles a major challenge in the field of electrokinetic separations and enrichment. Namely, its applicability to uncharged species in complex media and the integration of the separation platform with downstream detection and quantification methodologies. The long-term objective is to broaden the applicability of electrokinetic focusing that is based on the concept of ion concentration polarization through the development and standardization of versatile and reproducible chemical processes. New ion concentration polarization strategies that address current limitations are investigated. These strategies take advantage of guest-host interactions that impart charge to neutral species; unique features of ion depleted zone initiation, growth, and stability in viscous fluids; and the enhanced sensitivity of in situ detection with three-dimensional flow-through electrode architectures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

爱荷华州州立大学的Robbyn Anand教授得到了化学系化学测量和成像项目的支持，以开发分析技术，解决目前对难以处理的液体中化学化合物的选择性分离和富集的限制。新开发的技术灵敏地检测富集部位的分离化合物。重点是目前无法获得的化合物类别，包括药物，食品添加剂和生物液体，食品和药物制剂中存在的临床相关目标。该项目通过更准确的医疗诊断和保证高质量的食品和药物来改善公共卫生，从而对社会产生积极影响。该项目支持开发研讨会式的大学课程，通过让学生参与关于工作与生活平衡、工作场所气候、创业精神和网络等主题的讨论，促进科学的多样性。此外，个案研究开发，以提高研究生水平的电化学教材的学习成果。该项目解决了电动分离和浓缩领域的一个重大挑战。也就是说，它适用于复杂介质中的不带电物质，以及分离平台与下游检测和定量方法的集成。长期目标是通过开发和标准化多功能和可重复的化学过程，扩大基于离子浓差极化概念的电动聚焦的适用性。研究了解决电流限制的新离子浓差极化策略。这些策略利用了给予中性物质电荷的客体-主体相互作用;在粘性流体中离子耗尽区起始、生长和稳定性的独特特征;以及三维流动原位检测的增强的灵敏度-该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查进行评估，被认为值得支持的搜索.