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CAREER: Advancing Ion Concentration Polarization to Enrich New Classes of Analytes from Complex Media and to Interface with Analysis: Breaking the Glass Ceiling on Enrichment

职业：推进离子浓度偏振以从复杂介质中富集新类型的分析物并与分析相结合：打破富集的玻璃天花板

基本信息

批准号：
1849109
负责人：
Robbyn Anand
金额：
$ 62万
依托单位：
Iowa State University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-02-15 至 2024-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1849109&HistoricalAwards=false
关键词：
CAREER Advancing Ion Concentration Polarization

项目摘要

Professor Robbyn Anand of Iowa State University is supported by the Chemical Measurement and Imaging Program of the Division of Chemistry to develop analytical techniques that address current limitations to the selective separation and enrichment of chemical compounds from difficult to handle fluids. The newly developed technique sensitively detects the separated compounds at the site of enrichment. The focus is on currently inaccessible categories of compounds, including medications, food additives, and clinically-relevant targets present in biological fluids, food, and pharmaceutical formulations. The project positively impacts society by improving public health through more accurate medical diagnostics and the assurance of high quality food and medications. The project supports the development of a workshop-style college course to promote diversity in science by engaging students in discussions on topics such as work-life balance, workplace climate, entrepreneurship, and networking. In addition, case studies are developed to improve learning outcomes in graduate-level electrochemistry educational material. The project tackles a major challenge in the field of electrokinetic separations and enrichment. Namely, its applicability to uncharged species in complex media and the integration of the separation platform with downstream detection and quantification methodologies. The long-term objective is to broaden the applicability of electrokinetic focusing that is based on the concept of ion concentration polarization through the development and standardization of versatile and reproducible chemical processes. New ion concentration polarization strategies that address current limitations are investigated. These strategies take advantage of guest-host interactions that impart charge to neutral species; unique features of ion depleted zone initiation, growth, and stability in viscous fluids; and the enhanced sensitivity of in situ detection with three-dimensional flow-through electrode architectures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

爱荷华州立大学的罗宾·阿南德教授得到化学系化学测量和成像计划的支持，开发分析技术，以解决目前从难以处理的流体中选择性分离和浓缩化合物的限制。这项新开发的技术可以灵敏地检测到浓缩点的分离化合物。重点放在目前无法接触到的化合物类别上，包括药物、食品添加剂和存在于生物液、食品和药物配方中的临床相关靶标。该项目通过更准确的医疗诊断和保证高质量的食品和药物来改善公共健康，从而积极影响社会。该项目支持开发一个工作坊式的大学课程，通过让学生参与诸如工作与生活平衡、工作环境、创业和网络等主题的讨论，促进科学的多样性。此外，还开发了案例研究，以提高研究生水平的电化学教材的学习结果。该项目解决了电动分离和浓缩领域的一个重大挑战。也就是说，它适用于复杂介质中的未带电物种，以及分离平台与下游检测和定量方法的集成。长期目标是通过开发和标准化多种可重复使用的化学过程，扩大以离子浓度极化概念为基础的电动聚焦的适用性。研究了解决电流限制的新的离子浓度极化策略。这些策略利用了将电荷传递给中性物种的宾主相互作用；粘性流体中离子贫乏区域的启动、生长和稳定性的独特特征；以及三维流动电极架构的现场检测的增强敏感性。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。