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Doctoral Dissertation Research: Understanding the Brain-Machine Interface in the Engineering of Prosthetic Technologies

博士论文研究：了解假肢技术工程中的脑机接口

基本信息

批准号：
1850672
负责人：
Joao Biehl
金额：
$ 2.52万
依托单位：
Princeton University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-15 至 2019-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1850672&HistoricalAwards=false
关键词：
Doctoral Dissertation Research Understanding Brain

项目摘要

People suffering from traumatic limb loss often experience both withdrawal and heightening of sensation. Deprived of the limb's sensory feedback, roughly 80% of amputees experience intense, mysterious phantom limb pain. Scientists are developing brain-controlled prosthetics that enable patients to move their prosthetic limbs through thought, while also receiving sensory feedback (touch) from the environment back into the body. Yet touch, pain, and sensation are difficult to quantify, deeply subjective experiences, requiring a delicate process of communication, collaboration, and translation among patients, scientists, and engineers. How do patients' sensory experience, their sense of being in a body in space, and their awareness of their phantom limb, influence the development of such biotechnologies? How do patients actively participate, and even intervene, in the design of human-machine interfaces? These are the questions addressed in this project, to inform the development of biotechnologies. In addition to providing funding for the training of a graduate student in anthropology, the project will broadly disseminate its data and findings to aid organizations in developing more effective biotechnology design and clinical practice to improve the lives of disabled individuals.Graduate student, Alexandra Middleton, under the supervision of Dr. Joao Biehl of Princeton University, will investigate the role of patients as simultaneously experimental subjects and active co-innovators in human-machine interface design. To understand how the brain-machine interface is engineered, the project examines the role of patient experience and feedback in the development of biotechnology. This ethnographic research will be conducted in Gothenburg, Sweden, a global epicenter of engineering brain-machine interface prosthetic technologies. The researcher will follow two clinical trials, accompanying patients as they engage with experimental neuroprosthetics in the laboratory, clinic, and their homes. These devices are the first in the world of their kind to travel outside the laboratory for home use in everyday life. Ethnographic focus will be placed on the home as a key site of science-in-the-making. Through participant observation in patients' homes and interviews with both patients and family members, the researcher will investigate how everyday experiences constitute a particular type of expertise about the use and possibilities of these devices. Circling back to the clinic and laboratory, the researcher will trace how these forms of expertise inform decisions in design as well as therapeutic communication. Archival research will examine the particular economic and social contexts that make such experimentation and development possible. Findings from this research will offer insight into the ways that human perspective and technology use can inform laboratory development and clinical communication, as well as highlighting the importance of involving disabled individuals in the design of technologies aimed at enhancing their lives. These insights will inform clinical trial design and practice among scientists, clinicians, and patients, as well as human-machine relations generally.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

遭受创伤性肢体丧失的人通常会经历感觉的退缩和增强。由于失去了肢体的感觉反馈，大约80%的截肢者会经历强烈的、神秘的幻肢疼痛。科学家们正在开发大脑控制的假肢，使患者能够通过思维移动假肢，同时还能从环境中接收感官反馈（触摸）回到身体。然而，触摸、疼痛和感觉是难以量化的，是非常主观的体验，需要患者、科学家和工程师之间进行微妙的沟通、协作和翻译。患者的感官体验、他们在太空中的身体感觉以及他们对幻肢的意识如何影响此类生物技术的发展？患者如何积极参与，甚至干预人机界面的设计？这些都是在这个项目中解决的问题，为生物技术的发展提供信息。除了资助人类学研究生的培训外，该项目还将广泛传播其数据和研究结果，以帮助各组织开发更有效的生物技术设计和临床实践，以改善残疾人的生活。将研究患者在人机界面设计中同时作为实验对象和积极的共同创新者的作用。为了了解脑机接口是如何设计的，该项目研究了患者体验和反馈在生物技术发展中的作用。这项人种学研究将在瑞典的哥德堡进行，那里是全球工程脑机接口假肢技术的中心。研究人员将跟踪两项临床试验，陪同患者在实验室，诊所和家中进行实验性神经修复术。这些设备是世界上第一个在实验室之外的日常生活中使用的设备。民族志的重点将放在家庭作为科学的关键网站在-的决策。通过在患者家中的参与式观察以及与患者和家庭成员的访谈，研究人员将调查日常经验如何构成有关这些设备的使用和可能性的特定类型的专业知识。回到诊所和实验室，研究人员将追踪这些形式的专业知识如何为设计和治疗沟通提供决策信息。档案研究将研究使这种实验和发展成为可能的特定经济和社会背景。这项研究的结果将深入了解人类视角和技术使用可以为实验室开发和临床交流提供信息的方式，并强调让残疾人参与旨在改善他们生活的技术设计的重要性。这些见解将为科学家、临床医生和患者之间的临床试验设计和实践，以及一般的人机关系提供信息。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。