Redox catalysis strategies for synthesis

该项目正在解决处于现代化学合成、催化和可持续发展前沿的问题，例如对环境友好的重要化学品的制造。光化学是将太阳能转化为化学能，是实现这一目标的重要组成部分。光化学在有机合成中的应用传统上需要危险的试剂和/或高能的紫外光。在这个项目中，斯蒂芬森博士正在研究如何使用能够收集阳光的复合体为化学反应提供动力。重要的是，这项研究项目是与制药公司合作进行的。这种合作使新方法能够迅速融入实际应用中。斯蒂芬森博士的研究小组参与了几个外展项目，以吸引小学(3-12年级)的学生，目的是激励下一代科学家和领导者。例如，研究团队正在为女性在密歇根大学的数学、工程和科学(女性)以及密歇根数学和科学学者(MMSS)项目中表现更出色做出贡献。在化学系化学催化项目的资助下，密歇根大学安娜堡分校的斯蒂芬森博士正在研究如何利用瞬时产生的电子供体-受体(EDA)复合体来开发化学合成的新方法。应用Mulliken理论的基本原理，合理设计可见光活性EDA络合物是可能的。用紫外可见光谱对其进行了表征。EDA光催化代表着有机合成方法发展的一个令人振奋的新前沿。在这方面，正在开发芳烃三氟甲基化和自由基芳基置换的方法，以快速产生分子复杂性。通过对每个反应机理的详细了解，与AbbVie工艺研究和开发团队合作，开发的方法迅速转化为工业规模。斯蒂芬森博士的研究小组参与了几个推广项目，利用他们在合成化学方面的专业知识吸引小学(3-12年级)的学生，目的是激励下一代科学领袖。斯蒂芬森博士参与了密歇根大学数学、工程和科学(FETMES)和密歇根数学和科学学者(MMSS)项目的女性，允许小学生在有趣和支持性的氛围中直接参与到合成化学教学中，同时也鼓励他们从事STEM事业。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This project is addressing issues - such as the environmentally-friendly manufacturing of economically-important chemicals - that are at the forefront of modern chemical synthesis, catalysis, and sustainability. Photochemistry is the conversion of solar energy into chemical energy and is an important component of this goal. The application of photochemistry to organic synthesis has traditionally required hazardous reagents and/or high energy, ultraviolet light. In this project, Dr. Stephenson is studying the use of complexes that harvest sunlight to power chemical reactions. Importantly, this research project is being carried out in collaboration with pharmaceutical companies. This collaboration enables the rapid incorporation of the new methods into practical applications. Dr. Stephenson's research group participates in several outreach programs to engage grade school (3rd-12th grade) students, with the intention of inspiring the next generation of scientists and leaders. For example, the research team is contributing to the Females Excelling More in Mathematics, Engineering, and the Science (FEMMES) and the Michigan Math and Science Scholars (MMSS) programs at the University of Michigan. This outreach is directly engaging grade school students in a fun and supportive atmosphere, while also encouraging them to pursue a career in STEM.With funding from the Chemical Catalysis program of the Chemistry Division, Dr. Stephenson at the University of Michigan - Ann Arbor is studying how transiently generated electron donor-acceptor (EDA) complexes can be leveraged for the development of new methods in chemical synthesis. The rational design of visible light-active EDA complexes is possible by applying basic principles of Mulliken theory. Such complexes are characterized by UV-Vis spectroscopy. EDA photocatalysis represents an exciting new frontier for the development of methods in organic synthesis. In this regard, methods for arene trifluoromethylation and radical aryl transpositions, for the rapid generation of molecular complexity, are being developed. Through a detailed understanding of each reaction mechanism, the developed methods are rapidly translated to industrial scale in collaboration with the AbbVie Process Research and Development team. Dr. Stephenson's research group is involved in several outreach programs that apply their expertise in synthetic chemistry to engage grade school (3rd-12th grade) students, with the intention of inspiring the next generation of scientific leaders. Dr. Stephenson's involvement in the Females Excelling More in Mathematics, Engineering, and the Science (FEMMES) and the Michigan Math and Science Scholars (MMSS) programs at the University of Michigan have allowed for the direct engagement of grade school students to teach synthetic chemistry in a fun and supportive atmosphere while also encouraging them to pursue a career in STEM.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.