Plasmoresistor device for optoelectronic transduction

用于光电转换的等离子电阻装置

• 批准号: 1908167
• 负责人: Parag Banerjee
• 金额: $ 33万
• 依托单位: The University of Central Florida Board of Trustees
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1908167&HistoricalAwards=false
• 关键词: Plasmoresistor; device; optoelectronic; transduction

Coronary heart disease, which leads to heart attack, is the most common type of heart disease killing 380,000 people annually. It has been widely accepted that a specific molecule, the cardiac troponin I, in blood serves as a highly sensitive and specific indicator for the detection of heart attack. While there are numerous commerically available bioassays available to detect this molecule with requisite sensitivity and specificity, these tests are time consuming and require specially trained personnel. This project seeks to create a novel class of sensors which can detect cardiac troponin I with high sensitivity and extreme selectivity in resource-limited settings. The long-term impact of the proposed work is to shorten the time between the occurrence and the determination of a heart attack such that appropriate treatment can be administered rapidly thus saving lives and improving patient quality of life. The proposal will focus on hiring women and minority graduate students for conducting the above research. Opportunities for undergraduate students to conduct summer research will be provided. The project will also provide opportunities for high-school students, especially those from underrepresented groups, to participate in the micro- and nano-fabrication summer camps in the university cleanroom. The experiential learning-based science activities will directly help these high school students to prepare for colleges and improve their chances of pursuing professional STEM education.This project will exploit the conversion of an optical signal into an electrical output on a device platform to detect the cardiac biomarker, the cardiac troponin I, with high sensitivity and specificity. The device will consist of gold nanoparticles covered with a semiconducting film and contacted by two electrodes. The conductance of the illuminated device will be determined by plasmonically induced, energetic hot electrons generated in gold nanoparticles and subsequently injected into the semiconducting film. In turn, the gold nanoparticles will be functionalized to specifically capture the target biomarker associated with heart attack. Upon cardiac troponin I binding, changes to the immediate dielectric environment will result in a shift in localized surface plasmon resonance wavelength of the gold nanoparticles. This will result in the reduction of plasmonically generated hot electron injection and hence lower the conductivity of the illuminated device. Therefore, the quantifiable loss in photoconductivity will signal the presence and concentration of the biomarker, the cardiac troponin I, for detecting heart attack.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

导致心脏病发作的冠心病是最常见的心脏病类型，每年导致38万人死亡。人们普遍认为，血液中的一种特殊分子，即心肌肌钙蛋白I，是检测心脏病发作的一种高度敏感和特异性的指标。虽然有许多商业上可用的生物测定方法可用于检测这种分子，具有必要的灵敏度和特异性，但这些测试既耗时又需要经过专门培训的人员。该项目旨在创建一种新型传感器，可以在资源有限的情况下以高灵敏度和极高的选择性检测心脏肌钙蛋白I。拟议的工作的长期影响是缩短心脏病发作发生和确定之间的时间，以便能够迅速进行适当的治疗，从而挽救生命并提高患者的生活质量。该提案将重点雇用女性和少数民族研究生进行上述研究。将为本科生提供进行暑期研究的机会。该项目还将为高中生，特别是那些来自代表性不足群体的高中生提供机会，让他们参加在大学洁净室举办的微纳米制造夏令营。以体验式学习为基础的科学活动将直接帮助这些高中生为大学做准备，并提高他们接受专业STEM教育的机会。该项目将利用一个设备平台将光信号转换为电输出，以高灵敏度和特异性检测心脏生物标志物——心肌肌钙蛋白I。该装置将由覆盖着半导体薄膜的金纳米粒子组成，并由两个电极连接。被照亮装置的电导率将由等离子体感应决定，在金纳米颗粒中产生的高能热电子随后被注入半导体薄膜。反过来，金纳米颗粒将被功能化，以特异性捕获与心脏病发作相关的目标生物标志物。在心肌肌钙蛋白I结合后，直接介电环境的变化将导致金纳米粒子局部表面等离子体共振波长的变化。这将导致等离子体产生的热电子注入减少，从而降低照明器件的电导率。因此，光电导率的可量化损失将表明生物标志物（心脏肌钙蛋白I）的存在和浓度，用于检测心脏病发作。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Achieving near-zero temperature coefficient of resistivity in atomic layer deposition TiSi x N films through composition tuning

通过成分调节在原子层沉积 TiSi x N 薄膜中实现接近零的电阻率温度系数

• DOI: 10.1116/6.0000453
• 发表时间: 2020
• 期刊: Journal of Vacuum Science & Technology A
• 影响因子: 2.9
• 作者: Feit, Corbin;Chugh, Srishti;Dhamdhere, Ajit R.;Kim, Hae Young;Dabas, Shaurya;Rathi, Somilkumar J.;Mukherjee, Niloy;Banerjee, Parag
• 通讯作者: Banerjee, Parag

Release Rate Studies of 5-Aminosalacylic Acid Coated with Atomic Layer-Deposited Al 2 O 3 and ZnO in an Acidic Environment

原子层沉积Al 2 O 3 和ZnO包覆的5-氨基水杨酸在酸性环境中的释放速率研究

• DOI: 10.1021/acsabm.2c00750
• 发表时间: 2023
• 期刊: ACS Applied Bio Materials
• 影响因子: 4.7
• 作者: Sosa, Jaynlynn;Berriel, S. Novia;Feit, Corbin;Currie, Taylor M.;Shultz, Lorianne R.;Rudawski, Nicholas G.;Jurca, Titel;Banerjee, Parag
• 通讯作者: Banerjee, Parag

Identification of Active Sites for Ammonia Electrosynthesis on Ruthenium

• DOI: 10.1021/acsenergylett.2c02175
• 发表时间: 2022-11
• 期刊: ACS Energy Letters
• 影响因子: 22
• 作者: Lin Hu;H. Pillai;Corbin Feit;Kaige Shi;Zhengning Gao;P. Banerjee;Hongliang Xin;Xiaofeng Feng

Gold Nanorod Size-Dependent Fluorescence Enhancement for Ultrasensitive Fluoroimmunoassays

• DOI: 10.1021/acsami.0c20303
• 发表时间: 2021-02-23
• 期刊: ACS APPLIED MATERIALS & INTERFACES
• 影响因子: 9.5
• 作者: Liang, Chao;Luan, Jingyi;Singamaneni, Srikanth
• 通讯作者: Singamaneni, Srikanth

Enhancement of ZnSe stability during optical composite processing via atomic layer deposition

• DOI: 10.1016/j.jnoncrysol.2021.121259
• 发表时间: 2021-11
• 期刊: Journal of Non-Crystalline Solids
• 影响因子: 3.5
• 作者: Matthieu Chazot;Alexandros Kostogiannes;M. Julian;Corbin Feit;Jaynlynn Sosa;M. Kang;Cesar Blanco