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Nanomilling of organic compounds in stirred media mills

在搅拌介质磨机中对有机化合物进行纳米研磨

基本信息

批准号：
238114850
负责人：
Professor Dr.-Ing. Arno Kwade
金额：
--
依托单位：
Institut für Partikeltechnik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2021-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/238114850?language=en
关键词：
Nanomilling organic compounds stirred media

项目摘要

Objective of this research project are in-depth investigations of the fracture behavior of organic crystals during stirred media milling. Moreover, the impact of formulation and process parameters on product characteristics and grinding limit will be investigated in detail. Building on the main results of the first funding period, the research shall be focused on the complex interplay of particle breakage, agglomeration, precipitation as well as ripening phenomena, which occur in parallel during media milling of organic crystals. Investigations concerning the influence of solubility on product formation as well as complex stability issues of the strongly hydrophic organic compounds are part of the study. Furthermore, the detailed characterization of the solid state and microstructure, respectively, of the organic crystal coupled to liquid phase analysis will gain a deeper understanding of the production of organic particles during media milling. Furthermore, fundamental mechanisms affecting the grinding limit of organic particles shall be identified and investigated in great detail. Based on the main results of the first and second funding period, the stress model for the description and optimization of grinding processes of inorganic materials in stirred media mills will be extended with regard to organic crystals. In addition, a strategy to minimize grinding media wear will be devolved to improve the product quality. Hence, the second funding period comprises the following essential aspects:- Distinction between particle fracture and precipitation as well as ripening effects during media milling to gain a deeper understanding of the mechanical production of organic particles.- Distinction between surface and volume effects during wet grinding of organic crystals.- Characterization and in-depth understanding of the complex interplay of organic crystal, stabilization additives and liquid medium as well as their impact on product characteristics.- Identification of the limiting mechanisms regarding the grinding limit of organic particles.- Development of a strategy to minimize abrasion and characterization of the interactions between wear, product particles and formulation.

本研究的目的是深入研究搅拌介质研磨过程中有机晶体的断裂行为。此外，将详细研究配方和工艺参数对产品特性和研磨极限的影响。在第一个资助期的主要成果的基础上，研究将集中在颗粒破碎，团聚，沉淀以及成熟现象的复杂相互作用上，这些现象在有机晶体的介质研磨过程中同时发生。关于溶解度对产物形成的影响以及强亲水性有机化合物的复杂稳定性问题的调查是研究的一部分。此外，结合液相分析，分别对有机晶体的固态和微观结构进行详细表征，将更深入地了解介质研磨过程中有机颗粒的产生。此外，还应确定并详细研究影响有机颗粒研磨极限的基本机制。基于第一和第二个资助期的主要结果，将在有机晶体方面扩展用于描述和优化搅拌介质米尔斯中无机材料研磨过程的应力模型。此外，还将提出一种减少研磨介质磨损的策略，以提高产品质量。因此，第二个资助期包括以下基本方面：-区分颗粒破碎和沉淀以及介质研磨过程中的熟化效应，以更深入地了解有机颗粒的机械生产。有机晶体湿法研磨过程中表面效应和体积效应的区别。表征和深入了解有机晶体、稳定添加剂和液体介质的复杂相互作用及其对产品特性的影响。确定有关有机颗粒研磨极限的限制机制。制定一项策略，以最大限度地减少磨损，并表征磨损、产品颗粒和配方之间的相互作用。