2019 Chromosome Dynamics GRC: Genetic, Molecular and Physical Views of Genomes and Their Organizational Principles

该奖项将为参加2019年戈登染色体动力学研究会议(2019年6月23-28日在缅因州纽里举行)的研究生和博士后研究人员提供支持。这一领域的领先会议汇集了从数学、计算到生物学等不同学科的研究人员，他们正在研究染色体结构/动力学和功能。三位主旨演讲者(两位知名科学家和一位初级科学家)将展示该领域的突破和新方向，各个职业阶段的不同科学家群体将通过研讨会和海报会议介绍他们的工作。旨在产生更广泛影响的计划活动包括关于科学包容性和生活规则的讨论，这是NSF的十大想法之一。还将有大量非正式的资源共享和联网机会。近年来，新技术的发展加速了染色体生物学的发现。它还导致了具有深远影响的高度专业化，但也可能阻碍对包装DNA的生物物理性质如何影响遗传密码的功能、维护和传播的更充分了解。这次会议为研究人员提供了一个重要的纽带，促进了对染色体组织和对基因调控的影响、染色体背景下的DNA复制和修复、减数分裂染色体的组织和分离以及着丝粒和染色体稳定性等主题的最新发现的讨论。它还将促进下一代科学家的培训和职业发展，包括在染色体生物学领域的代表不足的少数族裔。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The award will provide support for graduate students and post-doctoral researchers to attend the 2019 Gordon Research Conference on Chromosome Dynamics (June 23-28, 2019 in Newry, ME). This leading conference in the field brings together researchers from diverse disciplines ranging from mathematics and computing to biology, who are studying chromosome structure/dynamics and function. Three keynote speakers (two established and one junior scientists) will showcase breakthroughs and new directions in the field, and a diverse group of scientists at all career stages will present their work through seminars and poster sessions. Programmatic activities aimed at broader impact include discussion sessions on inclusivity in science and on Rules of Life, one of NSF's 10 Big Ideas. There will also be plenty of informal opportunities for resource sharing and networking.New technology development has accelerated discoveries in chromosome biology in recent years. It has also led to high levels of specialization that have profound impact, but can also hinder fuller understanding of how the biophysical properties of packaged DNA influence the function, maintenance and propagation of the genetic code. This conference serves as a vital link for investigators by facilitating discussion of latest discoveries in topics such as chromosome organization and the impact on gene regulation, DNA replication and repair in the chromosomal context, meiotic chromosomal organization and segregation, as well as centromeres and chromosome stability. It will also facilitate training and career development of the next generation of scientists, including underrepresented minorities, in the field of chromosome biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.