2019 Chromosome Dynamics GRC: Genetic, Molecular and Physical Views of Genomes and Their Organizational Principles

该奖项将为研究生和博士后研究人员提供支持，以参加2019年戈登染色体动力学研究会议（2019年6月23日至28日在纽里，ME）。这一领域的领先会议汇集了来自不同学科的研究人员，从数学和计算到生物学，他们正在研究染色体结构/动力学和功能。三位主旨发言人（两名资深科学家和一名初级科学家）将展示该领域的突破和新方向，各个职业阶段的科学家将通过研讨会和海报会议展示他们的工作。旨在产生更广泛影响的方案活动包括关于科学包容性和NSF十大理念之一的生活规则的讨论会。此外，还将有大量非正式的机会进行资源共享和联网。近年来，新技术的发展加速了染色体生物学的发现。它还导致了高度专业化，产生了深远的影响，但也可能妨碍更充分地了解包装DNA的生物物理特性如何影响遗传密码的功能、维持和传播。本次会议作为一个重要的环节，为研究人员通过促进讨论的最新发现的主题，如染色体组织和基因调控的影响，DNA复制和修复的染色体背景下，减数分裂染色体组织和分离，以及着丝粒和染色体稳定性。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The award will provide support for graduate students and post-doctoral researchers to attend the 2019 Gordon Research Conference on Chromosome Dynamics (June 23-28, 2019 in Newry, ME). This leading conference in the field brings together researchers from diverse disciplines ranging from mathematics and computing to biology, who are studying chromosome structure/dynamics and function. Three keynote speakers (two established and one junior scientists) will showcase breakthroughs and new directions in the field, and a diverse group of scientists at all career stages will present their work through seminars and poster sessions. Programmatic activities aimed at broader impact include discussion sessions on inclusivity in science and on Rules of Life, one of NSF's 10 Big Ideas. There will also be plenty of informal opportunities for resource sharing and networking.New technology development has accelerated discoveries in chromosome biology in recent years. It has also led to high levels of specialization that have profound impact, but can also hinder fuller understanding of how the biophysical properties of packaged DNA influence the function, maintenance and propagation of the genetic code. This conference serves as a vital link for investigators by facilitating discussion of latest discoveries in topics such as chromosome organization and the impact on gene regulation, DNA replication and repair in the chromosomal context, meiotic chromosomal organization and segregation, as well as centromeres and chromosome stability. It will also facilitate training and career development of the next generation of scientists, including underrepresented minorities, in the field of chromosome biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.