Optimizing concentric ring electrode design for noninvasive electrophysiological measurement

美国国家科学基金会部落学院和大学方案的使命是建立为美国土著居民服务的教育机构的研究和教学能力。该项目由Dine学院管理，名为“优化同心环电极设计用于无创电生理测量”，与TCUP使命一致。本研究的目的是改进同心环电极传感器（CRE）的设计，该传感器用于生物医学技术以监测活组织的健康状况。该研究致力于提高该技术在检测组织电信号方面的准确性，然后将其应用于提高医生诊断患者病情的能力。该项目建立在Dine学院工程应用数学实验室（MEA实验室）的基础上，并扩展了该实验室的主要研究方向。通过支付本科生研究助理职位与MEA实验室的项目提供，它也支持学院的使命提供强大的学习机会为students.This研究重点是重要的，因为能够估计表面拉普拉斯在每个电极构成的克雷斯的主要生物医学意义。通过最佳CRE设计进一步提高拉普拉斯估计的准确性可以有助于目前使用克雷斯从例如大脑、肠、心脏或子宫获取诊断电信号的许多非侵入性电生理测量系统的进步。本研究项目的目标将通过以下方式实现：1）扩展一般环间距离优化问题的解决方案，适用于各种条件，以及2）将中心盘的半径和同心环的各个宽度沿着当前包括的参数（诸如环的数量和内部参数）一起并入CRE设计优化过程中。该奖项反映了NSF的法定使命，并被认为是值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估的支持。

The mission of the NSF Tribal Colleges and Universities Program (TCUP) is build the research and instructional capacity of education institutions serving Indigenous populations in the United States. The project, administered by Dine College and titled "Optimizing Concentric Ring Electrode Design for Noninvasive Electrophysiological Measurement", aligns well with the TCUP mission. The goal of this research project is to improve the design of concentric ring electrodes sensors (CRE), which are used in biomedical technology to monitor the health of living tissues. The research strives to boost the accuracy of the technology in detecting electrical signals from tissue, which can then be applied to improve doctors' ability to diagnose their patients' conditions. This project builds on and expands the primary research direction of the Mathematics for Engineering Applications laboratory (MEA lab) at Dine College. Through the paid undergraduate research assistant positions with the MEA lab the project provides, it also supports the mission of the college to deliver robust learning opportunities for students.This research focus is important because the ability to estimate the surface Laplacian at each electrode constitutes the primary biomedical significance of CREs. Further improvement of the accuracy of Laplacian estimation via optimal CRE designs may contribute to the advancement of numerous noninvasive electrophysiological measurement systems that currently use CREs to acquire diagnostic electrical signals from the brain, intestines, heart or uterus, for example. The goal of this research project will be achieved by 1) expanding the solutions of the general inter-ring distances optimization problem for a wide range of conditions, and 2) incorporating the radius of the central disc and individual widths of the concentric rings into the CRE design optimization process along with the currently included parameters such as the number of rings and inter-ring distances.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.