Criticality and Active Dynamics in Mechanical Detection by the Inner Ear

内耳机械检测的关键性和主动动力学

• 批准号: 1916136
• 负责人: Dolores Bozovic
• 金额: $ 58.95万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1916136&HistoricalAwards=false
• 关键词: Criticality; Active; Dynamics; Mechanical; Detection

The auditory (hearing) and vestibular (balance) systems provide us with rich information about the world around us. To achieve this, these sensory systems perform remarkable mechanical detection, responding to very small movements in the hair cells of the inner ear. This sensitivity has to be achieved even in a noisy environment in order to allow individuals to distinguish sounds that they want to hear and interpret from background noise. While the fundamental process of hearing is known, the processes that support acuity of hearing (being able to clearly detect the important sounds) are not well understood. This project will look at the fundamental mechanics and physics of the response of hair cells in order to better understand the dynamics of the hearing process. Beyond advancing understanding of this important physiological process, the knowledge gained from the research may also inform the development of sensor systems that mimic the process of the ear. The award will enable the inclusion of undergraduate researchers, recruited through programs that broaden the participation of students from under-represented minorities. The laboratory will also include high school students in the research project, focusing on encouraging women to pursue studies in this field.This project has two guiding hypotheses. First, that the coupling between hair cells changes the dynamics of the system, poising it closer to criticality. Second, that the presence of weak chaos in the coupled system enhances its sensitivity. In order to investigate thse hypotheses, this project will use in vitro preparations of the bullfrog sacculus to assess how coupled systems of hair bundles achieve their detection. Specifically, the research will look for signatures of criticality, which would be a regime that leads to a highly sensitive response and a broad range of power-law behavior. The project will also explore the role of chaotic dynamics in the fully coupled system in order to determine how chaoticity in individual bundles is modified by the coupling, as well as how it affects the performance of the full system. To elucidate the role of these dynamic regimes, the project will use preparations that incorporate different coupling conditions. For one set of experiments, it will use hybrid preparations, in which different numbers of hair bundles will be connected to build arrays of different sizes. For another set of experiments, semi-intact systems will be used, which preserve the innate, overlying membrane. The researcher hypothesizes that the system is poised near criticality, on the weakly oscillatory side, and that the critical oscillations exhibit chaotic dynamics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

听觉（听觉）和前庭（平衡）系统为我们提供了关于周围世界的丰富信息。为了实现这一点，这些感觉系统执行显着的机械检测，响应内耳毛细胞中非常小的运动。即使在嘈杂的环境中也必须达到这种灵敏度，以便使个人能够从背景噪音中区分他们想要听到和解释的声音。 虽然听觉的基本过程是已知的，但支持听觉敏锐度的过程（能够清楚地检测到重要的声音）还没有得到很好的理解。 这个项目将着眼于毛细胞反应的基本力学和物理学，以便更好地理解听觉过程的动态。 除了促进对这一重要生理过程的理解之外，从研究中获得的知识还可以为模拟耳朵过程的传感器系统的开发提供信息。 该奖项将使本科研究人员，通过扩大学生的参与代表性不足的少数民族的计划招募的包容性。实验室还将把高中生纳入研究项目，重点是鼓励妇女在这一领域进行研究。 首先，毛细胞之间的耦合改变了系统的动力学，使其更接近临界状态。 第二，耦合系统中弱混沌的存在增强了其灵敏度。 为了验证这些假说，本计画将利用牛蛙球囊的体外制备，以评估毛束的耦合系统如何达成其侦测。具体来说，这项研究将寻找关键性的签名，这将是一个导致高度敏感的反应和广泛的幂律行为的制度。该项目还将探索混沌动力学在完全耦合系统中的作用，以确定耦合如何修改单个束中的混沌性，以及它如何影响整个系统的性能。为了阐明这些动态机制的作用，该项目将使用包含不同耦合条件的制剂。对于一组实验，它将使用混合制剂，其中不同数量的头发束将被连接以构建不同大小的阵列。对于另一组实验，将使用半完整的系统，其保留了先天的覆盖膜。研究人员假设该系统处于临界附近，在弱振荡侧，临界振荡表现出混沌动力学。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

Synchronization and chaos in systems of coupled inner-ear hair cells

内耳毛细胞耦合系统的同步和混沌

• DOI: 10.1103/physrevresearch.3.013266
• 发表时间: 2021
• 期刊: Physical Review Research
• 影响因子: 4.2
• 作者: Faber, Justin;Li, Hancheng;Bozovic, Dolores
• 通讯作者: Bozovic, Dolores

Efferent Activity Controls Hair Cell Response to Mechanical Overstimulation

传出活动控制毛细胞对机械过度刺激的反应

• DOI: 10.1523/eneuro.0198-22.2022
• 发表时间: 2022
• 期刊: eneuro
• 影响因子: 3.4
• 作者: Lin, Chia-Hsi Jessica;Bozovic, Dolores
• 通讯作者: Bozovic, Dolores

Chimera states and frequency clustering in systems of coupled inner-ear hair cells

• DOI: 10.1063/5.0056848
• 发表时间: 2021-07-01
• 期刊: CHAOS
• 影响因子: 2.9
• 作者: Faber, Justin;Bozovic, Dolores
• 通讯作者: Bozovic, Dolores