Collaborative Research: An in vivo/in silico Approach to Delineate the Effect of Age on Pressure Ulcer Susceptibility

合作研究:描述年龄对压疮易感性影响的体内/计算机方法

基本信息

  • 批准号:
    1916663
  • 负责人:
  • 金额:
    $ 32.04万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-07-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

Pressure ulcers, or bed sores, are a debilitating condition that affects more than 3 million Americans. Today, it is understood that pressure ulcers follow from continued compression of skin in patients that have lost the ability to reposition themselves and relieve that pressure. For example, patients in wheel chairs or patients that have become bedridden frequently suffer from pressure ulcers. Patients of advanced age are particularly prone to pressure ulcers. While we understand the behavioral factors that may, in part, explain this increased incidence, the age-related anatomical and physiological factors that may contribute to increased risk in patients of advanced age have remained mostly unexplored and unknown. This knowledge is important, as it may provide a pathway to age-specific treatment strategies. This project will use a mouse model of pressure ulcer formation and progression to investigate these age-related anatomical and physiological factors and their contribution to the increased risk of pressure ulcers due to age. Furthermore, the research will integrate these results into a comprehensive computational model that will be a first step toward predicting pressure ulcers. With such a model it will be possible to not only design better support systems -- such as wheelchairs, mattresses, and prostheses -- but also to explore novel diagnostic technologies and therapeutic strategies. This project will integrate a diverse group of undergraduate students into the research, using peer mentoring approaches. Finally, and most importantly, in order to accelerate the transfer of knowledge from this study to the general public, educational podcasts on pressure ulcers will be designed that will be disseminated by integrating them into successful, long-running podcast series.The overall goal of this research is to quantify the effect of age on non-behavioral factors of pressure ulcer formation using mice as a biological model system in combination with a novel multi-scale, multi-physics computer model. This goal is supported by two objectives. The first will determine the non-behavior factors that increase the risk of pressure ulcer initiation in the elderly. Using young and old mice, the role of skin compliance in the microvascular collapse and ischemia that occurs prior to pressure ulcer will be investigated. The second objective is to determine the non-behavioral factors that increase the risk of pressure ulcer progression by looking at three contributory factors: ischemic injury, reperfusion injury, and mechanical injury. For both objectives, the experimental data will be integrated into a multi-scale, multi-physics model that will then be able to link matrix-cell and cell-cell signalling to pressure ulcer formation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
压力性溃疡或褥疮是一种使人衰弱的疾病,影响着300多万美国人。今天,据了解,压力性溃疡是由于患者的皮肤持续受压而导致的,这些患者已经失去了重新定位自己和减轻压力的能力。例如,坐轮椅的患者或卧床不起的患者经常遭受压疮。高龄患者特别容易发生压疮。虽然我们了解行为因素可能部分解释这种发病率增加,但可能导致高龄患者风险增加的年龄相关解剖学和生理学因素仍然大多未被探索和未知。这方面的知识很重要,因为它可以提供一个途径,以年龄特定的治疗策略。该项目将使用压疮形成和进展的小鼠模型来研究这些与年龄相关的解剖学和生理学因素及其对因年龄而增加的压疮风险的贡献。此外,这项研究将把这些结果整合到一个综合的计算模型中,这将是预测压疮的第一步。有了这样一个模型,不仅可以设计更好的支持系统-如轮椅、床垫和假肢-而且可以探索新的诊断技术和治疗策略。这个项目将整合一个不同的本科生群体的研究,使用同伴指导的方法。 最后,也是最重要的是,为了加速本研究的知识向公众的转移,将设计有关压疮的教育播客,并将其整合到成功的、长期运行的播客系列。这项研究的总体目标是量化年龄对非压力性溃疡形成的行为因素,使用小鼠作为生物模型系统,结合新的多尺度、多物理计算机模型。 这一目标得到两个目标的支持。 第一个将确定增加老年人压疮发生风险的非行为因素。 使用年轻和年老的小鼠,将研究皮肤顺应性在压力性溃疡之前发生的微血管塌陷和缺血中的作用。 第二个目标是通过观察三个促成因素来确定增加压疮进展风险的非行为因素:缺血性损伤,再灌注损伤和机械损伤。 对于这两个目标,实验数据将被整合到一个多尺度,多物理模型,然后将能够连接矩阵细胞和细胞细胞信号,以压力溃疡的形成。这个奖项反映了NSF的法定使命,并已被认为是值得通过评估使用基金会的智力价值和更广泛的影响审查标准的支持。

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Data-driven modeling of the mechanical behavior of anisotropic soft biological tissue
  • DOI:
    10.1007/s00366-022-01733-3
  • 发表时间:
    2021-07
  • 期刊:
  • 影响因子:
    8.7
  • 作者:
    Vahidullah Tac;V. Sree;M. Rausch;A. B. Tepole
  • 通讯作者:
    Vahidullah Tac;V. Sree;M. Rausch;A. B. Tepole
Data-driven anisotropic finite viscoelasticity using neural ordinary differential equations
Teaching Material Testing and Characterization with an Open, Accessible, and Affordable Mechanical Test Device
使用开放、易于访问且经济实惠的机械测试设备进行教学材料测试和表征
  • DOI:
    10.1007/s43683-021-00056-x
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Sugerman, Gabriella P.;Rausch, Manuel K.
  • 通讯作者:
    Rausch, Manuel K.
Cross-evaluation of stiffness measurement methods for hydrogels
  • DOI:
    10.1016/j.polymer.2022.125316
  • 发表时间:
    2022-09
  • 期刊:
  • 影响因子:
    4.6
  • 作者:
    N. Richbourg;M. Rausch;N. Peppas
  • 通讯作者:
    N. Richbourg;M. Rausch;N. Peppas
Computational systems mechanobiology of growth and remodeling: Integration of tissue mechanics and cell regulatory network dynamics
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Manuel Rausch其他文献

Polyconvex physics-augmented neural network constitutive models in principal stretches
主伸长率中的多凸物理增强神经网络本构模型
  • DOI:
    10.1016/j.ijsolstr.2025.113469
  • 发表时间:
    2025-09-01
  • 期刊:
  • 影响因子:
    3.800
  • 作者:
    Adrian Buganza Tepole;Asghar Arshad Jadoon;Manuel Rausch;Jan Niklas Fuhg
  • 通讯作者:
    Jan Niklas Fuhg
Blood Clots Are Mechanically Weak in Patients with Sickle Cell Disease
  • DOI:
    10.1182/blood-2023-186716
  • 发表时间:
    2023-11-02
  • 期刊:
  • 影响因子:
  • 作者:
    Grace Bechtel;Gabriella Sugerman;Alicia Chang;Manuel Rausch;Adam Bush
  • 通讯作者:
    Adam Bush
The folded X-pattern is not necessarily a statistical signature of decision confidence
折叠的 X 模式不一定是决策置信度的统计签名
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Manuel Rausch;Michael Zehetleitner
  • 通讯作者:
    Michael Zehetleitner
Content, granularity, and type 2 sensitivity of subjective measures of visual consciousness
视觉意识主观测量的内容、粒度和 2 类敏感性
  • DOI:
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Manuel Rausch
  • 通讯作者:
    Manuel Rausch
The statistical signature of confidence is not necessarily a folded X-pattern
置信度的统计特征不一定是折叠的 X 模式
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Manuel Rausch;Michael Zehetleitner
  • 通讯作者:
    Michael Zehetleitner

Manuel Rausch的其他文献

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{{ truncateString('Manuel Rausch', 18)}}的其他基金

Collaborative Research: Inferring The In Situ Micro-Mechanics of Embedded Fiber Networks by Leveraging Limited Imaging Data
合作研究:利用有限的成像数据推断嵌入式光纤网络的原位微观力学
  • 批准号:
    2127925
  • 财政年份:
    2022
  • 资助金额:
    $ 32.04万
  • 项目类别:
    Standard Grant
Understanding Mechano-Fibrinolysis: Fiber-Scale Multiphysics Experiments and Models
了解机械纤维蛋白溶解:纤维尺度多物理场实验和模型
  • 批准号:
    2105175
  • 财政年份:
    2021
  • 资助金额:
    $ 32.04万
  • 项目类别:
    Continuing Grant
CAREER: Toward a Fundamental Understanding of Why Thrombus Dissolves, Persists, or Breaks Off
职业生涯:对血栓为何溶解、持续或破裂有一个基本的了解
  • 批准号:
    2046148
  • 财政年份:
    2021
  • 资助金额:
    $ 32.04万
  • 项目类别:
    Standard Grant

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Cell Research (细胞研究)
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    2007
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  • 项目类别:
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