MRI: Acquisition of High Resolution Gas Chromatography Mass Spectrometer with Electron Ionization/Chemical Ionization and Multi-mode Injection Capability

MRI:购置具有电子电离/化学电离和多模式进样功能的高分辨率气相色谱质谱仪

基本信息

  • 批准号:
    1919594
  • 负责人:
  • 金额:
    $ 32.59万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-01 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Valerie Frerichs from SUNY at Buffalo and colleagues Luis Colon, Diana Aga and David Lacy are acquiring a high-resolution gas-chromatograph tandem mass spectrometer (Orbitrap). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a gas chromatograph can separate mixtures of gaseous compounds before they reach the mass spectrometer. The tandem mass spectrometry capabilities increase the ability to identify molecules. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. The number and range of enabled research projects generate and disseminate knowledge. Proficiency using contemporary instrumentation is pivotal to the training of future generations of researchers and students choosing non-scientific which is important in science policy and governance. Increasing early exposure to the process of scientific research is based on models from the NSF funded Center for Authentic Science Practice in Education (based at Purdue University) and from the NSF funded National Center for Case Study Teaching in Science (based at U. Buffalo). Advancement of scientific knowledge in environmental and other areas contributes to the achievement of societally-relevant outcomes.The award is aimed at enhancing research and education at all levels. It especially impacts investigations on the fate, transport, effects, and mitigation of contaminants in the environment and the exploration of enzyme active site modeling, molecular energy science, and catalyst design The mass spectrometer is also used for the identification of synthetic di-oxygenase enzymes and for the study of small molecule activation and generation. The instrument is employed in other projects related to environmental toxins, metabolomics, and mechanistic synthetic studies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该奖项由主要研究仪器和化学仪器计划支持。来自纽约州立大学布法罗分校的Valerie Frerichs教授和同事Luis Colon,Diana阿加和大卫莱西正在购买一台高分辨率气相色谱串联质谱仪(Orbitrap)。一般来说,质谱(MS)是用于识别和表征复杂样品中嵌入的少量化学物质的关键分析方法之一。在一个典型的实验中,成分流入质谱仪,在那里它们被电离成离子,并测量离子的质量。这种高灵敏度的技术可以研究复杂混合物中的分子结构。带有气相色谱仪的仪器可以在气体化合物到达质谱仪之前将其分离。串联质谱能力提高了识别分子的能力。此次收购加强了大学和地区的研究基础设施。该工具通过利用这一现代分析技术使不同群体的学生参与研究和研究培训,扩大了参与。获得支持的研究项目的数量和范围产生和传播知识。熟练使用现代仪器是培养未来几代研究人员和学生选择非科学的关键,这在科学政策和治理中很重要。增加对科学研究过程的早期接触是基于NSF资助的教育中真实科学实践中心(位于普渡大学)和NSF资助的国家科学案例研究教学中心(位于美国)的模型。布法罗)。环境和其他领域科学知识的进步有助于实现与社会相关的成果。该奖项旨在加强各级的研究和教育。它特别影响对环境中污染物的命运,运输,影响和减轻的调查,以及酶活性位点建模,分子能量科学和催化剂设计的探索质谱仪也用于合成双加氧酶的鉴定和小分子活化和生成的研究。该仪器被用于与环境毒素、代谢组学和机械合成研究相关的其他项目。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Highly Regioselective Copper‐Catalyzed Transfer Hydrodeuteration of Unactivated Terminal Alkenes
高度区域选择性铜催化未活化末端烯烃的转移加氢氘化
  • DOI:
    10.1002/chem.202104340
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Reyes, Albert;Torres, Emanuel Rivera;Vang, Zoua Pa;Clark, Joseph R.
  • 通讯作者:
    Clark, Joseph R.
Synthesis of a Bench-Stable Manganese(III) Chloride Compound: Coordination Chemistry and Alkene Dichlorination
实验室稳定的氯化锰 (III) 化合物的合成:配位化学和烯烃二氯化
  • DOI:
    10.1021/jacs.2c08509
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    15
  • 作者:
    Saju, Ananya;Griffiths, Justin R.;MacMillan, Samantha N.;Lacy, David C.
  • 通讯作者:
    Lacy, David C.
Optimized workflow for unknown screening using gas chromatography high‐resolution mass spectrometry expands identification of contaminants in silicone personal passive samplers
使用气相色谱高分辨率质谱法优化未知物筛查工作流程,扩大了硅胶个人被动采样器中污染物的识别范围
Hydrogenative Catalysis with Three‐Coordinate Zinc Complexes Supported with PN Ligands is Enhanced Compared to PNP Analogs
与 PNP 类似物相比,PN 配体支持的三配位锌配合物的氢化催化性能得到增强
  • DOI:
    10.1002/chem.202201042
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Paul, Sanchita;Morgante, Pierpaolo;MacMillan, Samantha N.;Autschbach, Jochen;Lacy, David C.
  • 通讯作者:
    Lacy, David C.
Reversible Photoisomerization in a Ru cis -Dihydride Catalyst Accessed through Atypical Metal–Ligand Cooperative H 2 Activation: Photoenhanced Acceptorless Alcohol Dehydrogenation
通过非典型金属配体协同 H 2 活化实现 Ru 顺式二氢化物催化剂中的可逆光异构化:光增强无受体醇脱氢
  • DOI:
    10.1021/acs.organomet.1c00648
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Fanara, Paul M.;Vigneswaran, Vipulan;Gunasekera, Parami S.;MacMillan, Samantha N.;Lacy, David C.
  • 通讯作者:
    Lacy, David C.
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Valerie Frerichs其他文献

ConfChem Conference on Case-Based Studies in Chemical Education: Use of Case Study for the Introductory Chemistry Laboratory Environment
ConfChem 化学教育案例研究会议:案例研究在介绍性化学实验室环境中的应用
  • DOI:
    10.1021/ed200799h
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Valerie Frerichs
  • 通讯作者:
    Valerie Frerichs
Reverse Phase High-Performance Liquid Chromatography Method for the Analysis of Amprenavir, Efavirenz, Indinavir, Lopinavir, Nelfinavir and Its Active Metabolite (M8), Ritonavir, and Saquinavir in Heparinized Human Plasma
反相高效液相色谱法分析肝素化人血浆中的安普那韦、依非韦伦、茚地那韦、洛匹那韦、奈非那韦及其活性代谢物 (M8)、利托那韦和沙奎那韦
  • DOI:
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Kim Keil;Valerie Frerichs;R. DiFrancesco;G. Morse
  • 通讯作者:
    G. Morse
Determination of glucose by capillary electrophoresis/laser‐induced fluorescence in transdermally collected samples
通过毛细管电泳/激光诱导荧光测定经皮收集的样品中的葡萄糖
  • DOI:
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    Valerie Frerichs;L. Colón
  • 通讯作者:
    L. Colón
Trace level determination of substance P using capillary electrophoresis and laser-induced fluorescence
使用毛细管电泳和激光诱导荧光测定痕量 P 物质
  • DOI:
    10.1016/j.microc.2004.03.018
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    4.8
  • 作者:
    Valerie Frerichs;Jennifer K. Herrmann;A. Aguirre;L. Colón
  • 通讯作者:
    L. Colón
Omeprazole Absorption from a Compounded Transdermal Formulation in Healthy Volunteers
  • DOI:
    10.1331/1544345054475603
  • 发表时间:
    2005-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Curtis E. Haas;Lydia Lin;Denise Cloen;Thomas Kufel;Richard Moon;Valerie Frerichs
  • 通讯作者:
    Valerie Frerichs

Valerie Frerichs的其他文献

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