MRI: Acquisition of High Resolution Gas Chromatography Mass Spectrometer with Electron Ionization/Chemical Ionization and Multi-mode Injection Capability

该奖项由主要研究仪器和化学仪器项目支持。纽约州立大学布法罗分校的Valerie Frerichs教授及其同事Luis Colon、Diana Aga和David Lacy正在获得一台高分辨率气相色谱串联质谱仪(Orbitrap)。通常，质谱仪是用于识别和表征复杂样品中的少量化学物种的关键分析方法之一。在一个典型的实验中，这些成分流入质谱仪，在那里它们被电离成离子，并测量离子的质量。这种高度灵敏的技术使研究复杂混合物中的分子结构成为可能。带有气相色谱仪的仪器可以在气体化合物到达质谱仪之前将其分离。串联质谱学能力提高了识别分子的能力。此次收购加强了该大学和该地区的研究基础设施。该仪器通过让不同的学生群体参与研究和使用这种现代分析技术进行研究培训，扩大了参与度。能够产生和传播知识的研究项目的数量和范围。熟练使用现代仪器对于培训未来一代研究人员和选择非科学的学生至关重要，这在科学政策和管理中很重要。增加对科学研究过程的早期接触是基于NSF资助的教育中真实科学实践中心(总部设在普渡大学)和NSF资助的国家科学案例研究教学中心(设在布法罗大学)的模型。环境和其他领域科学知识的进步有助于取得具有社会意义的成果。该奖项旨在加强各级的研究和教育。特别是对环境中污染物的去向、迁移、影响和缓解的研究，以及酶活性部位建模、分子能量科学和催化剂设计的探索。质谱仪还用于鉴定合成双加氧酶和研究小分子的激活和生成。该仪器还用于与环境毒素、代谢组学和机械合成研究相关的其他项目。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Instrumentation Programs. Professor Valerie Frerichs from SUNY at Buffalo and colleagues Luis Colon, Diana Aga and David Lacy are acquiring a high-resolution gas-chromatograph tandem mass spectrometer (Orbitrap). In general, mass spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of chemical species embedded in complex samples. In a typical experiment, the components flow into a mass spectrometer where they are ionized into ions and the ions' masses are measured. This highly sensitive technique allows the structure of molecules in complex mixtures to be studied. An instrument with a gas chromatograph can separate mixtures of gaseous compounds before they reach the mass spectrometer. The tandem mass spectrometry capabilities increase the ability to identify molecules. The acquisition strengthens the research infrastructure at the University and regional area. The instrument broadens participation by involving diverse groups of students in research and research training using this modern analytical technique. The number and range of enabled research projects generate and disseminate knowledge. Proficiency using contemporary instrumentation is pivotal to the training of future generations of researchers and students choosing non-scientific which is important in science policy and governance. Increasing early exposure to the process of scientific research is based on models from the NSF funded Center for Authentic Science Practice in Education (based at Purdue University) and from the NSF funded National Center for Case Study Teaching in Science (based at U. Buffalo). Advancement of scientific knowledge in environmental and other areas contributes to the achievement of societally-relevant outcomes.The award is aimed at enhancing research and education at all levels. It especially impacts investigations on the fate, transport, effects, and mitigation of contaminants in the environment and the exploration of enzyme active site modeling, molecular energy science, and catalyst design The mass spectrometer is also used for the identification of synthetic di-oxygenase enzymes and for the study of small molecule activation and generation. The instrument is employed in other projects related to environmental toxins, metabolomics, and mechanistic synthetic studies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.