MRI: Acquisition of a High Resolution Confocal Laser Scanning Microscope for the Advancement of Materials and Biological Research at Oklahoma State University

俄克拉荷马州立大学(OSU)获奖购买共聚焦激光扫描显微镜。该仪器将提供先进的成像能力，以支持来自俄克拉何马州俄克拉何马州斯蒂尔沃特分校、塔尔萨分校和其他研究所的10多个系的教师、博士后研究人员、研究生和本科生的研究。拟议的显微镜将成为俄亥俄州立大学显微镜实验室用于公共宣传和参与的一系列设备的一部分，包括K-12级别的STEM教育。该项目还被纳入俄勒冈州州立大学的研究任务，并为来自传统上在科学界代表性不足的群体的学生提供支持和培训机会。该项目将对任职人数偏低群体的62人产生直接影响。收购这一仪器不仅将影响研究和研究培训，还将通过促进俄勒冈州州立大学的研究和帮助招收代表性不足的少数族裔学生，在培养一支多样化的、具有全球竞争力的STEM劳动力队伍方面发挥重要作用。该显微镜具有高分辨率扫描、活细胞成像和3D重建的专门能力。将支持的主要项目包括但不限于：干细胞分化建模、3D组织工程建模、用于基因传递的病毒样颗粒以及对病毒感染的先天免疫反应。其他受影响的研究领域包括宿主与病原体的相互作用、病原体的检测和缓解、信号通路的调节、细胞分化、植物发育和纳米材料的表征。该奖项提供的新能力将使用户能够扩大他们的研究范围，推进当前的项目，并促进新的研究方向。这项研究将通过专业陈述、同行评议出版物、课程开发、研讨会和外联活动进行传播。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to the Oklahoma State University (OSU) to acquire a confocal laser scanning microscope. The instrument will provide advanced imaging capabilities to support research from faculty, postdoctoral researchers, graduate students and undergraduate students in over 10 departments from OSU Stillwater campus, Tulsa campus, and other institutes in Oklahoma. The proposed microscope will become part of the array of equipment that the OSU Microscopy Lab uses for public outreach and engagement, including STEM education at the K-12 level. This project is also embedded in the OSU research mission and provides support and training opportunities to students from groups that are traditionally underrepresented in the sciences. This project will have an immediate impact on 62 individuals from underrepresented groups. Acquisition of this instrument will not only impact research and research training but will also play an important role in development of a diverse, globally competitive STEM workforce by advancing research at OSU and assisting in the recruitment of underrepresented minority students. The microscope has specialized capabilities for high-resolution scanning, live-cell imaging, and 3D reconstruction. Primary projects to be supported include but are not limited to: stem cell differentiation modeling, 3D tissue-engineered modeling, virus-like particles for gene delivery, and innate immune response to viral infection. Other research areas impacted include host-pathogen interactions, pathogen detection and mitigation, regulation of signaling pathways, cell differentiation, plant development, and the characterization of nanomaterials. New capabilities provided by the award will allow users to expand the scope of their research, advance current projects and promote new research directions. The research will be disseminated through professional presentations, peer-reviewed publications, curriculum development, workshops, and outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.