MRI: Acquisition of a High Resolution Confocal Laser Scanning Microscope for the Advancement of Materials and Biological Research at Oklahoma State University

MRI：俄克拉荷马州立大学购买高分辨率共焦激光扫描显微镜以促进材料和生物学研究

• 批准号: 1919805
• 负责人: Yolanda Vasquez
• 金额: $ 49.22万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919805&HistoricalAwards=false
• 关键词: MRI; Acquisition; Resolution; Confocal; Laser

An award is made to the Oklahoma State University (OSU) to acquire a confocal laser scanning microscope. The instrument will provide advanced imaging capabilities to support research from faculty, postdoctoral researchers, graduate students and undergraduate students in over 10 departments from OSU Stillwater campus, Tulsa campus, and other institutes in Oklahoma. The proposed microscope will become part of the array of equipment that the OSU Microscopy Lab uses for public outreach and engagement, including STEM education at the K-12 level. This project is also embedded in the OSU research mission and provides support and training opportunities to students from groups that are traditionally underrepresented in the sciences. This project will have an immediate impact on 62 individuals from underrepresented groups. Acquisition of this instrument will not only impact research and research training but will also play an important role in development of a diverse, globally competitive STEM workforce by advancing research at OSU and assisting in the recruitment of underrepresented minority students. The microscope has specialized capabilities for high-resolution scanning, live-cell imaging, and 3D reconstruction. Primary projects to be supported include but are not limited to: stem cell differentiation modeling, 3D tissue-engineered modeling, virus-like particles for gene delivery, and innate immune response to viral infection. Other research areas impacted include host-pathogen interactions, pathogen detection and mitigation, regulation of signaling pathways, cell differentiation, plant development, and the characterization of nanomaterials. New capabilities provided by the award will allow users to expand the scope of their research, advance current projects and promote new research directions. The research will be disseminated through professional presentations, peer-reviewed publications, curriculum development, workshops, and outreach activities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

俄克拉荷马州立大学（OSU）获得了一个共聚焦激光扫描显微镜。该仪器将提供先进的成像能力，以支持俄勒冈州立大学斯蒂尔沃特校区、塔尔萨校区和俄克拉荷马州其他研究所的10多个系的教师、博士后研究人员、研究生和本科生的研究。该显微镜将成为俄勒冈州立大学显微镜实验室用于公众宣传和参与的一系列设备的一部分，包括K-12级别的STEM教育。该项目也被纳入俄勒冈州立大学的研究任务，并为来自传统上在科学领域代表性不足的群体的学生提供支持和培训机会。这个项目将对62名来自代表性不足群体的个人产生直接影响。该仪器的获得不仅将影响研究和研究培训，还将通过推进俄勒冈州立大学的研究和协助招募代表性不足的少数民族学生，在培养多样化、具有全球竞争力的STEM劳动力方面发挥重要作用。该显微镜具有高分辨率扫描、活细胞成像和3D重建的专门功能。支持的主要项目包括但不限于：干细胞分化建模、3D组织工程建模、用于基因传递的病毒样颗粒和对病毒感染的先天免疫反应。其他受影响的研究领域包括寄主-病原体相互作用、病原体检测和缓解、信号通路调节、细胞分化、植物发育和纳米材料的表征。该奖项提供的新功能将允许用户扩展其研究范围，推进当前项目并促进新的研究方向。这项研究将通过专业报告、同行评议出版物、课程开发、讲习班和外展活动进行传播。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。