Stimuli-Responsive Soft Materials
刺激响应软材料
基本信息
- 批准号:1921578
- 负责人:
- 金额:$ 39.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-01 至 2021-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Oil and water don't mix and exist as two separate phases of matter. Phase separation of soft matter mixtures such as lipids, oil and water can be exploited to create lipid coated droplets or soft particles. Two soft particles can self-assemble with a lipid bilayer connecting the two soft particles. The soft particle composition can also include more complex matter such as polymers. When a biological ion channel is incorporated into one of the soft particles, it self-assembles into the lipid bilayer forming a communication channel, where, for example, water and ions can be exchanged between the soft particles, and the exchange can be modulated by an external stimulus such as an electric field, mechanical force, pH, etc. In addition to creating a platform for exchange of contents between the two soft particles, the external stimulus can also induce mechanical deformations in the soft particles. Self-assembled soft particles can enable sensing of external stimuli, creation of synthetic cell-like structures, compartmentalized reactions and other important functions. In spite of tremendous technological impact of self-assembled soft particles, the mechanics of the self-assembly process, complex deformations of soft particles under various stimuli, and the functionality of ion channels beyond what is already known in biology are not clear. This project will train next generation scientists to develop fundamental insights into mechanics of stimuli-responsive soft materials. This award will also support inclusion of undergraduate students in research and education, engagement of women and minority students, and outreach to K-12 students.This research aims to understand the mechanics of self-assembly and functionality of stimuli-responsive soft materials. Specifically, detailed atomistic calculations will be performed to understand the molecular mechanics of the self-assembly process, mechanical behavior of stimuli-responsive soft materials, and complex interactions between soft particles when they interact via ion channels. To understand the mechanics of larger size soft particles, coarse-grained calculations, based on the iterative Boltzmann inversion technique, will be performed. To compute macroscopic properties of stimuli-responsive soft materials, multiscale calculations integrating phenomena at various length scales will be performed. In addition to developing fundamental knowledge, various applications of stimuli-responsive soft materials will be investigated. It is anticipated that this project will not only lead to significant advances in mechanics of stimuli-responsive soft materials but also enable studies of ion channels beyond their known functionality in biology.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
油和水不混合,作为物质的两个独立相存在。软物质混合物如脂质、油和水的相分离可用于产生脂质包被的液滴或软颗粒。两个软颗粒可以与连接两个软颗粒的脂质双层自组装。软颗粒组合物还可以包括更复杂的物质,例如聚合物。当将生物离子通道结合到一个软颗粒中时,它自组装到脂质双层中,形成连通通道,其中,例如,水和离子可以在软颗粒之间交换,并且交换可以通过外部刺激如电场、机械力、pH等来调节。除了在两个软颗粒之间产生内容物交换的平台之外,外部刺激也可在软颗粒中引起机械变形。自组装的软颗粒可以感知外部刺激,创造合成细胞样结构,区室化反应和其他重要功能。尽管自组装软粒子的巨大技术影响,自组装过程的力学,软粒子在各种刺激下的复杂变形,以及超出生物学已知的离子通道的功能尚不清楚。该项目将培养下一代科学家,以发展对刺激响应软材料力学的基本见解。该奖项还将支持本科生参与研究和教育,女性和少数民族学生的参与,以及K-12学生的推广。该研究旨在了解自组装的力学和刺激响应软材料的功能。具体而言,将进行详细的原子计算,以了解自组装过程的分子力学,刺激响应软材料的机械行为,以及软颗粒之间通过离子通道相互作用时的复杂相互作用。为了理解较大尺寸的软颗粒的力学,将进行基于迭代玻尔兹曼反演技术的粗粒度计算。为了计算刺激响应软材料的宏观特性,将进行多尺度计算,将各种长度尺度的现象整合在一起。除了发展基础知识外,还将研究刺激响应软材料的各种应用。预计该项目不仅将导致刺激响应软材料力学的重大进展,而且还将使离子通道的研究超越其在生物学中已知的功能。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Dynamic and weak electric double layers in ultrathin nanopores
超薄纳米孔中的动态和弱双电层
- DOI:10.1063/5.0048011
- 发表时间:2021
- 期刊:
- 影响因子:0
- 作者:Heiranian, Mohammad;Noh, Yechan;Aluru, Narayana R.
- 通讯作者:Aluru, Narayana R.
Ion Transport in Electrically Imperfect Nanopores
- DOI:10.1021/acsnano.0c04453
- 发表时间:2020-08-25
- 期刊:
- 影响因子:17.1
- 作者:Noh, Yechan;Aluru, Narayana R.
- 通讯作者:Aluru, Narayana R.
Universal Reduction in Dielectric Response of Confined Fluids
- DOI:10.1021/acsnano.0c03173
- 发表时间:2020-10-27
- 期刊:
- 影响因子:17.1
- 作者:Motevaselian, Mohammad H.;Aluru, Narayana R.
- 通讯作者:Aluru, Narayana R.
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Narayana Aluru其他文献
Combining Physics-Based and Evolution-Based Methods to Design Antibodies Against an Evolving Virus
- DOI:
10.1016/j.bpj.2019.11.2669 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Eric Jakobsson;Amir Barati Farimani;Emad Tajkhorshid;Narayana Aluru - 通讯作者:
Narayana Aluru
A Stacked Graphene-Al2O3 Nanopore Architecture for DNA Detection
- DOI:
10.1016/j.bpj.2011.11.3959 - 发表时间:
2012-01-31 - 期刊:
- 影响因子:
- 作者:
Shouvik Banerjee;B. Murali Venkatesan;David Estrada;Xiaozhong Jin;Vincent Dorgan;Vita Solovyeva;Myung-Ho Bae;Narayana Aluru;Eric Pop;Rashid Bashir - 通讯作者:
Rashid Bashir
Narayana Aluru的其他文献
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{{ truncateString('Narayana Aluru', 18)}}的其他基金
Collaborative Research: U.S.-Ireland R&D Partnership: Full Atomistic Understanding of Solid-Liquid Interfaces via an Integrated Experiment-Theory Approach
合作研究:美国-爱尔兰 R
- 批准号:
2137157 - 财政年份:2022
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
Electrically-Tunable Surface Energy and Reactivity of Graphene
石墨烯的电可调表面能和反应性
- 批准号:
1708852 - 财政年份:2017
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
Intrinsic and Extrinsic Losses in Nanoelectromechanical Systems
纳米机电系统的内在和外在损耗
- 批准号:
1506619 - 财政年份:2015
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
PIRE: Integrated Computational Materials Engineering for Active Materials and Interfaces in Chemical Fuel Production
PIRE:化学燃料生产中活性材料和界面的集成计算材料工程
- 批准号:
1545907 - 财政年份:2015
- 资助金额:
$ 39.83万 - 项目类别:
Continuing Grant
AF: Small: Density Estimation and Uncertainty Propagation in Complex Systems
AF:小:复杂系统中的密度估计和不确定性传播
- 批准号:
1420882 - 财政年份:2014
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
Structure, Dynamics and Transport of Multiphase Fluids
多相流体的结构、动力学和输运
- 批准号:
1264282 - 财政年份:2013
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
QMHP: Multiscale Analysis of Coupled Electrical, Mechanical Systems at Nanoscale
QMHP:纳米级耦合电气、机械系统的多尺度分析
- 批准号:
1127480 - 财政年份:2011
- 资助金额:
$ 39.83万 - 项目类别:
Continuing Grant
Transport and Interfacial Phenomena in Boron Nitride Nanotubes
氮化硼纳米管中的传输和界面现象
- 批准号:
0852657 - 财政年份:2009
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
AF:Small:Coarse-Grained Algorithms for Soft Matter
AF:Small:软物质的粗粒度算法
- 批准号:
0915718 - 财政年份:2009
- 资助金额:
$ 39.83万 - 项目类别:
Standard Grant
相似国自然基金
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Development of Novel Programmable Stimuli-responsive Polymers for Small-scale Soft Robots
用于小型软机器人的新型可编程刺激响应聚合物的开发
- 批准号:
DGECR-2021-00016 - 财政年份:2021
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$ 39.83万 - 项目类别:
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CAREER: Spatiotemporal Behavior of Stimuli- Responsive Soft Materials in Non-Equilibrium Processes
职业:非平衡过程中刺激响应软材料的时空行为
- 批准号:
2048219 - 财政年份:2021
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Development of Novel Programmable Stimuli-responsive Polymers for Small-scale Soft Robots
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- 批准号:
RGPIN-2021-02509 - 财政年份:2021
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Designing stimuli responsive soft nanoparticles for applications in biology
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552224-2020 - 财政年份:2020
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University Undergraduate Student Research Awards
Interfacially Driven Self-Assembly in Multiphase Soft Matter Systems : Microstructural Transitions Triggered by Stimuli-Responsive Interfaces
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- 批准号:
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