Bilateral decision networks for eye and arm movements

伊戈尔·卡根和梅勒妮·威尔克将研究大脑半球内和半球间相互作用在顶叶区域嘴唇和PRR中的作用，以做出与眼睛和手臂运动相关的决策。通过从这些区域进行双半球同时记录，结合单侧可逆失活，该小组将研究这个双边神经元网络如何处理视觉信息，以做出与眼跳和手臂到达运动规划相关的决定，以及受损半球的神经元扰动如何影响完整半球的活动。然后将这些实验的尖峰电位和局部场电位(LFP)活动与采用类似设计的同时进行的灵长类fMRI实验进行比较。这些实验将为揭示来自两个半球的特定神经元底物如何竞争和协作以做出行动决定，以及大脑半球间平衡受损如何导致失活诱导的缺陷提供新的线索。

Igor Kagan and Melanie Wilke will investigate the role of intra- and inter-hemispheric interactions in the parietal areas LIP and PRR for decision-making related to eye and arm movements. By performing bi-hemispheric simultaneous recordings from these areas, in combination with unilateral reversible inactivation, this group will investigate how this bilateral neuronal network processes visual information to arrive at decisions related to the planning of saccadic eye and arm reaching movements, and how neuronal perturbations in the lesioned hemisphere affect the activity in the intact hemisphere. Spiking and local field potential (LFP) activity from these experiments will then be compared to concurrent primate fMRI experiments that will employ a similar design. These experiments will shed new light on how specific neuronal substrates from both hemispheres compete and collaborate for arriving at decisions for actions, and how the impaired inter-hemispheric balance causes inactivation-induced deficits.