Self-regulation, glucose and heart rate variability - Interindividual differences and intraindividual dynamics

自我调节、血糖和心率变异性 - 个体差异和个体动态

• 批准号: 239474055
• 负责人: Professor Dr. Thomas Kubiak
• 金额: --
• 依托单位: Bundeszentrale für gesundheitliche Aufklärung (BZgA)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/239474055?language=en
• 关键词: Self; regulation; glucose; heart; rate

Healthy eating and regular physical activity are only two examples of various health-relevant behaviors which require self-regulation, i.e. the capacity to control and modify impulses and to regulate emotions, thoughts, and behaviors. In the last decade, research in self-regulation aimed at identifying biological correlates of self-regulation to deepen the understanding of success and failure in self-regulation. The theory of self-regulatory strength by Baumeister and colleagues hypothesized that intraindividual fluctuations in glucose levels reflect intraindividual variability in self-regulation. But, as the few studies supporting this hypothesis suffer from profound methodological problems, an unequivocal intepretation of results is not possible to date. Based on the theory of neurovisceral integration by Thayer and colleagues, interindividual differences in self-regulation can be explained by interindividual differences in heart rate variability (HRV). Various studies support this relationship. However, studies examining the role of interindividual differences in glucose metabolism and intraindividual fluctuations in HRV with respect to self-regulation are rare. Thus, the current research aims at evaluating the hypothesized role of glucose metabolism and HRV for self-regulation, taking into account intra- as well as interindividual differences. Therefore, a dual task paradigm (two consecutive self-regulation tasks) to assess self-regulatory performance will be combined with endocrinological methods to measure glucose utilization and simultaneous assessment of fluctuations in HRV. Additionally, interindividual differences in tonic HRV and markers of glucose metabolism will be evaluated with respect to self-regulatory performance. The current research project allows (1) evaluating intra- and interindividual dynamics in glucose metabolism and HRV with respect to self-regulation, (2) overcoming the methodological problems associated with measurement of fluctuations in blood glucose, and (3) assessing and comparing the contribution of both theories. Thereby, the study will provide key evidence to enhance the knowledge of the biological correlates of self-regulation and for the development of interventions to prevent self-regulatory failure.

健康的饮食和规律的身体活动只是需要自我调节的各种健康相关行为的两个例子，即控制和修改冲动以及调节情绪，思想和行为的能力。在过去的十年中，自我调节的研究旨在确定自我调节的生物学相关性，以加深对自我调节成功和失败的理解。Baumeister及其同事的自我调节强度理论假设葡萄糖水平的个体内波动反映了自我调节的个体内变异性。但是，由于支持这一假设的少数研究存在深刻的方法学问题，因此迄今为止不可能对结果进行明确的解释。根据Thayer及其同事的神经内脏整合理论，自我调节的个体间差异可以用心率变异性（HRV）的个体间差异来解释。各种研究都支持这种关系。然而，研究葡萄糖代谢的个体间差异和HRV的个体内波动与自我调节的作用是罕见的。因此，目前的研究旨在评估葡萄糖代谢和HRV自我调节的假设作用，考虑到内部以及个体间的差异。因此，评估自我调节性能的双任务范式（两个连续的自我调节任务）将与测量葡萄糖利用率的内分泌学方法和HRV波动的同时评估相结合。此外，将评价强直性HRV和葡萄糖代谢标志物的个体间差异与自我调节能力的关系。目前的研究项目允许（1）评估葡萄糖代谢和HRV自我调节方面的个体内和个体间动态，（2）克服与血糖波动测量相关的方法学问题，（3）评估和比较两种理论的贡献。因此，这项研究将提供关键证据，以提高自我调节的生物学相关性的知识，并为预防自我调节失败的干预措施的发展。