EFRI CEE: Engineered Retinal Epigenomics

EFRI CEE:工程视网膜表观基因组学

基本信息

  • 批准号:
    1933394
  • 负责人:
  • 金额:
    $ 200万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-15 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Retinal blindness, such as retinitis pigmentosa (RP), age-related macular degeneration (AMD), and glaucoma (POAG), is characterized by unrelenting neuronal death (photoreceptor loss in RP and AMD and ganglion cell loss in POAG). These prevalent blinding conditions account for a significant part of the estimated US$139 billion annual economic burden of vision disorders in the U.S. This group has, for the first time, shown that controlled microscale electromagnetic (EM) stimulation can lead to neuroprotective changes in the retina. The transformational vision of this project is to use non-invasive controlled electrical stimulation to induce genetic changes in the mammalian retina to slow down the progression of retinal blindness and perhaps even restore some level of the lost vision. The success of such an approach would spawn a whole new area in basic science, engineering, and medicine and in doing so develop new, innovative, cross-disciplinary educational programs critical to foster the next-generation of researchers of bioelectronic devices to affect protective genetic changes.A number of mechanisms have been identified as to why neuronal death occurs in different retinal blinding disorders (e.g., genetic mutations in RP, lipid metabolism abnormalities and inflammation in AMD, and elevated intraocular pressure in POAG to name a few). This group has shown that controlled microscale electromagnetic (EM) stimulation can lead to epigenetic retinal changes with implications for neuroprotective changes. The hypothesis of this proposal is that neuroepigenetic and chromatin remodeling of the retina induced through controlled electrical stimulation is a key molecular determinant of neuroprotection and could prove to be pivotal for the treatment of certain retinal blindness conditions. The vision of this proposal is that the findings will demonstrate how stimulation using electromagnetic (EM) fields can be effectively adopted to slow or halt the progression of prevalent retinal diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
视网膜盲,如视网膜色素变性(RP)、年龄相关性黄斑变性(AMD)和青光眼(POAG),其特征在于持续的神经元死亡(RP和AMD中的光感受器损失和POAG中的神经节细胞损失)。这些普遍的致盲状况占美国估计1390亿美元的视力障碍年度经济负担的重要部分。该小组首次表明,受控的微尺度电磁(EM)刺激可导致视网膜神经保护性变化。该项目的转型愿景是使用非侵入性受控电刺激来诱导哺乳动物视网膜的遗传变化,以减缓视网膜失明的进展,甚至可能恢复某种程度的视力丧失。这种方法的成功将在基础科学、工程和医学中产生一个全新的领域,并且在这样做的过程中,开发新的、创新的、跨学科的教育计划,这对于培养下一代生物电子设备的研究人员影响保护性遗传变化至关重要。RP中的基因突变、AMD中的脂质代谢异常和炎症以及POAG中的眼内压升高,仅举几例)。该小组已经表明,受控的微尺度电磁(EM)刺激可以导致表观遗传视网膜变化,并暗示神经保护性变化。该提议的假设是,通过受控电刺激诱导的视网膜的神经表观遗传和染色质重塑是神经保护的关键分子决定因素,并且可以证明对于某些视网膜失明病症的治疗是关键的。这项提案的愿景是,研究结果将展示如何有效地采用电磁(EM)场刺激来减缓或阻止流行性视网膜疾病的进展。该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Mark Humayun其他文献

The national center for the design of biomimetic nanoconductors
  • DOI:
    10.1016/j.nano.2006.10.070
  • 发表时间:
    2006-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    Eric Jakobsson;Narayan Aluru;Hagan Bayley;Jeff Brinker;Scott Feller;Mark Humayun;David A. LaVan;Gerhard Klimeck;Kevin Leung;Michael McLennan;Steve Plimpton;Umberto Ravaioli;Susan Rempe;Benoit Roux;Marco Saraniti;H. Larry Scott;X Zhu
  • 通讯作者:
    X Zhu

Mark Humayun的其他文献

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{{ truncateString('Mark Humayun', 18)}}的其他基金

EAGER: Engineered nano-scale barrier to prevent viral infections
EAGER:设计纳米级屏障以预防病毒感染
  • 批准号:
    2029677
  • 财政年份:
    2020
  • 资助金额:
    $ 200万
  • 项目类别:
    Standard Grant
Microbubble-assisted Crispr/Cas9 Delivery in Retina for Photoreceptor Therapeutics
微泡辅助 Crispr/Cas9 在视网膜中的递送用于光感受器治疗
  • 批准号:
    1805210
  • 财政年份:
    2018
  • 资助金额:
    $ 200万
  • 项目类别:
    Standard Grant
Retinal Nanophotoswitch
视网膜纳米光开关
  • 批准号:
    1404089
  • 财政年份:
    2014
  • 资助金额:
    $ 200万
  • 项目类别:
    Standard Grant
The Engineering Medical Therapeutic Technologies-Research Experience for Teachers
工程医学治疗技术-教师科研心得
  • 批准号:
    1301502
  • 财政年份:
    2013
  • 资助金额:
    $ 200万
  • 项目类别:
    Standard Grant
An Engineering Research Center for Biomimetic Microelectronic Systems
仿生微电子系统工程研究中心
  • 批准号:
    0310723
  • 财政年份:
    2003
  • 资助金额:
    $ 200万
  • 项目类别:
    Cooperative Agreement
Biocompatible Technology for a Light Sensitive Retinal Prosthesis
光敏视网膜假体的生物相容性技术
  • 批准号:
    0201927
  • 财政年份:
    2002
  • 资助金额:
    $ 200万
  • 项目类别:
    Continuing Grant
The Realization of a Retinal Prosthesis for the Totally Blind
全盲人视网膜假体的实现
  • 批准号:
    0335836
  • 财政年份:
    2001
  • 资助金额:
    $ 200万
  • 项目类别:
    Continuing Grant
Photosynthesis based light transduction on a retinal prosthetic chip: Interfacing molecular reactions centers, nano-channel glass, and the retina
视网膜假体芯片上基于光合作用的光传导:连接分子反应中心、纳米通道玻璃和视网膜
  • 批准号:
    0243329
  • 财政年份:
    2001
  • 资助金额:
    $ 200万
  • 项目类别:
    Continuing Grant
Photosynthesis based light transduction on a retinal prosthetic chip: Interfacing molecular reactions centers, nano-channel glass, and the retina
视网膜假体芯片上基于光合作用的光传导:连接分子反应中心、纳米通道玻璃和视网膜
  • 批准号:
    9980792
  • 财政年份:
    1999
  • 资助金额:
    $ 200万
  • 项目类别:
    Continuing Grant
The Realization of a Retinal Prosthesis for the Totally Blind
全盲人视网膜假体的实现
  • 批准号:
    9810914
  • 财政年份:
    1998
  • 资助金额:
    $ 200万
  • 项目类别:
    Continuing Grant

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1989年后英国展览和收藏史上中东欧(CEE)女性艺术家的代表性
  • 批准号:
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