Photosynthesis based light transduction on a retinal prosthetic chip: Interfacing molecular reactions centers, nano-channel glass, and the retina

视网膜假体芯片上基于光合作用的光传导：连接分子反应中心、纳米通道玻璃和视网膜

• 批准号: 9980792
• 负责人: Mark Humayun
• 金额: $ 52万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9980792&HistoricalAwards=false
• 关键词: Photosynthesis; based; light; transduction; retinal

This project will study interactions between three distinct systems: (1) photovoltaic molecules and/or membrane structures derived from green plants and artificial photosynthetic systems, (2) micron-scale electrode arrays formed by metal wires in microchannel glass, and (3) the retina. The proposed research will provide a knowledge and technology base necessary to integrate these systems towards the successful development of a novel, energy-efficient retinal prosthesis with a micron scale spatial resolution. More specifically, these objectives will be pursued: - Investigate interactions between natural and artificial photoactive structures and microchannel glass electrode arrays and to determine methods of attaching the structures to individual microwires. - Develop methods for depositing conductors throughout the entire length of the microchannels. - Determine the optimal size and shape for a retinal stimulating electrode. - Test the biocompatibility of the microchannel glass and photoactivated microchannel glass.Results of this research are likely to have broader application through improved understanding of metal/molecular interfaces, imaging technology, novel microfabrication techniques, and biological interfacing and testing.

本项目将研究三种不同系统之间的相互作用：（1）来自绿色植物和人工光合系统的光伏分子和/或膜结构，（2）由微通道玻璃中的金属线形成的微米级电极阵列，以及（3）视网膜。拟议的研究将提供必要的知识和技术基础，以整合这些系统，成功开发具有微米级空间分辨率的新型节能视网膜假体。更具体地说，将努力实现这些目标： - 研究天然和人工光敏结构与微通道玻璃之间的相互作用 电极阵列，并确定将该结构附着到各个微线的方法。 - 开发用于在微通道的整个长度上沉积导体的方法。 - 确定视网膜刺激电极的最佳尺寸和形状。 - 测试微通道玻璃和光活化微通道玻璃的生物相容性。通过提高对金属/分子界面、成像技术、新型微加工技术以及生物界面和测试的理解，本研究的结果可能具有更广泛的应用。