Guarding and evolving the genome: interactions between DNA-repair enzymes and damaged DNA

保护和进化基因组：DNA 修复酶和受损 DNA 之间的相互作用

• 批准号: DP0881520
• 负责人: Prof Charles Bond
• 金额: --
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0881520
• 关键词: Guarding; evolving; genome; interactions; between

The application of structural biology techniques to the area of DNA repair allows us to understand the full implications linking genes and proteins to the molecular mechanisms of diseases such as cancer and hereditory conditions. Studies in this highly internationally competitive area are already established in the Bond laboratory, which has recently relocated to Australia. The use of forward-thinking structural biology approaches to solve difficult technical problems will foster collaborations within Australia and with leading laboratories abroad, providing excellent up-to-date research training for students and postdoctoral researchers.

将结构生物学技术应用于DNA修复领域，使我们能够全面了解将基因和蛋白质与癌症和遗传疾病等疾病的分子机制联系起来的全部含义。在这个国际竞争激烈的领域的研究已经在邦德实验室建立，该实验室最近迁往澳大利亚。使用前瞻性结构生物学方法解决技术难题将促进澳大利亚国内以及与国外领先实验室的合作，为学生和博士后研究人员提供优秀的最新研究培训。