I-Corps: Cellulose Nano-fiber Composites for Biomedical Applications

I-Corps：用于生物医学应用的纤维素纳米纤维复合材料

• 批准号: 1936785
• 负责人: Michael Mason
• 金额: $ 5万
• 依托单位: University of Maine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1936785&HistoricalAwards=false
• 关键词: Corps; Cellulose; Nano; fiber; Composites

The broader impact/commercial potential of this I-Corps project includes new biomedical devices based on the use of cellulose nanofiber (CNF), a green, renewable, value-added product, as the material to usher in the new age of biomedical structural materials. Small surgical fixation devices (plates, screws, and pins), bone scaffolds/spacers (orthobiologics), surgical support devices, orthotics, and large wound therapies (negative pressure wound therapy) are all strong potential applications. Currently these markets are collectively valued at ~$20 billion and predicted to grow rapidly by 2025. Preliminary feedback indicates current materials are of inferior quality, not meeting the needs of doctors and patients, are difficult for surgeons to work with, and generally too costly. Titanium alloys are the most prevalent orthopedic material, but they demonstrate significant flaws including excessive stiffness, extreme density, questionable biocompatibility, and the inability for bio-resorption.This I-Corps project further develops a technology platform that makes it possible to produce porous solid forms derived from composites of the naturally derived fibrillated nanocellulose (CNF). Under the appropriate processing conditions, porous CNF solid-forms can be produced with impressive mechanical properties (porosity, strength-to-weight ratios, modulus, machinability, durability, biocompatibility, dissolution rate), exceeding that of modern plastics. Based on preliminary results, this material system may exhibit the desired properties for use in a number of healthcare related applications. Current research seeks to explore the feasibility of this material system to meet the specific requirements of these application areas. Through the I-Corps program this project will focus on identifying the specific needs, including material and design constraints, of medical and healthcare related stakeholders.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个i-Corps项目的更广泛的影响/商业潜力包括基于使用纤维素纳米纤维(CNF)的新的生物医学设备，CNF是一种绿色、可再生、增值的产品，作为引领生物医学结构材料新时代的材料。小型手术固定装置(钢板、螺丝和钉)、骨支架/间隔物(骨生物学)、手术支持装置、矫形器和大伤口疗法(负压伤口疗法)都是很有潜力的应用。目前，这些市场的总价值约为200亿美元，预计到2025年将快速增长。初步反馈表明，目前的材料质量较差，不能满足医生和患者的需求，外科医生难以操作，而且通常过于昂贵。钛合金是最流行的整形外科材料，但它们表现出明显的缺陷，包括过度僵硬、极高的密度、可疑的生物相容性以及无法进行生物吸收。这个i-Corps项目进一步开发了一个技术平台，使从天然衍生的纤维状纳米纤维素(CNF)复合材料中生产多孔固体形式成为可能。在合适的工艺条件下，可以制备出具有优异力学性能(孔隙率、强度重量比、模数、可加工性、耐久性、生物相容性、溶解速率)的多孔CNF固体模板，超过现代塑料。基于初步结果，该材料体系可展示用于许多医疗保健相关应用的所需属性。目前的研究旨在探索该材料系统的可行性，以满足这些应用领域的具体要求。通过i-Corps计划，该项目将专注于确定医疗和保健相关利益相关者的特定需求，包括材料和设计限制。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。