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CAREER: Palladium or Gold Catalyzed Decarboxylative Functionalization of (Hetero)Arenes

职业：钯或金催化（杂）芳烃的脱羧功能化

基本信息

批准号：
1942223
负责人：
Thomas Hoye
金额：
$ 52万
依托单位：
University of Minnesota-Twin Cities
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1942223&HistoricalAwards=false
关键词：
CAREER Palladium Gold Catalyzed Decarboxylative

项目摘要

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Joseph J. Topczewski of the University of Minnesota-Twin Cities. This research project is focusing on developing more efficient methods for organic synthesis. In this research, traditional starting materials are replaced with readily available, lower energy, safer, and less toxic carboxylic acids. These new synthetic methods are replacing prior reactions used in the synthesis of medicines, agrochemicals, and organic electronics. The broader impacts of this work include revitalizing and transforming undergraduate organic chemistry courses and bring a focus on advanced manufacturing method for the chemical industry. Furthermore, undergraduate students, graduate students, and faculty are engaging the citizens of Minnesota through their Market Science program, which brings science fair-like demonstrations to local farmers’ markets.Professor Topczewski and his students are developing new synthetic methods for the decarboxylative cross-coupling and functionalization of (hetero)aryl carboxylic acids. This research focuses on the mechanistic elucidation of the reaction cycle, optimization of the ligand and metal complexes, expansion of the substrate scope, and the development of a broader array of functionalization reactions. Several metal complexes and mechanisms of decarboxylative coupling are being investigated. The broader impacts of this work include recruiting a diverse cohort of scientists to be trained as next generation leaders in the chemical community and promoting outreach through Market Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

凭借该奖项，美国国家科学基金会化学部的化学合成项目正在支持明尼苏达大学双城分校 Joseph J. Topczewski 教授的研究。该研究项目的重点是开发更有效的有机合成方法。在这项研究中，传统的起始材料被易于获得、能量较低、更安全且毒性较小的羧酸取代。这些新的合成方法正在取代以前用于合成药物、农用化学品和有机电子产品的反应。这项工作的更广泛影响包括振兴和改造本科有机化学课程，并将重点放在化学工业的先进制造方法上。此外，本科生、研究生和教师正在通过他们的市场科学计划吸引明尼苏达公民的参与，该计划为当地农贸市场带来类似科学博览会的演示。Topczewski 教授和他的学生正在开发新的合成方法，用于（杂）芳基羧酸的脱羧交叉偶联和官能化。这项研究的重点是反应循环的机理阐明、配体和金属配合物的优化、底物范围的扩展以及更广泛的功能化反应的开发。几种金属络合物和脱羧偶联机制正在研究中。这项工作的更广泛影响包括招募一批多元化的科学家，接受培训，成为化学界的下一代领导者，并通过市场科学促进推广。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。