CAREER: Palladium or Gold Catalyzed Decarboxylative Functionalization of (Hetero)Arenes

职业:钯或金催化(杂)芳烃的脱羧功能化

基本信息

  • 批准号:
    1942223
  • 负责人:
  • 金额:
    $ 52万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-01 至 2022-04-30
  • 项目状态:
    已结题

项目摘要

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Joseph J. Topczewski of the University of Minnesota-Twin Cities. This research project is focusing on developing more efficient methods for organic synthesis. In this research, traditional starting materials are replaced with readily available, lower energy, safer, and less toxic carboxylic acids. These new synthetic methods are replacing prior reactions used in the synthesis of medicines, agrochemicals, and organic electronics. The broader impacts of this work include revitalizing and transforming undergraduate organic chemistry courses and bring a focus on advanced manufacturing method for the chemical industry. Furthermore, undergraduate students, graduate students, and faculty are engaging the citizens of Minnesota through their Market Science program, which brings science fair-like demonstrations to local farmers’ markets.Professor Topczewski and his students are developing new synthetic methods for the decarboxylative cross-coupling and functionalization of (hetero)aryl carboxylic acids. This research focuses on the mechanistic elucidation of the reaction cycle, optimization of the ligand and metal complexes, expansion of the substrate scope, and the development of a broader array of functionalization reactions. Several metal complexes and mechanisms of decarboxylative coupling are being investigated. The broader impacts of this work include recruiting a diverse cohort of scientists to be trained as next generation leaders in the chemical community and promoting outreach through Market Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
通过这个奖项,美国国家科学基金会化学部的化学合成项目支持明尼苏达大学双城分校的约瑟夫·j·托普切夫斯基教授的研究。这个研究项目的重点是开发更有效的有机合成方法。在这项研究中,传统的起始材料被容易获得、低能量、更安全、毒性更小的羧酸所取代。这些新的合成方法正在取代以前用于合成药物、农用化学品和有机电子产品的反应。这项工作的广泛影响包括振兴和转变本科有机化学课程,并将重点放在化学工业的先进制造方法上。此外,本科生、研究生和教师正在通过他们的市场科学项目吸引明尼苏达州的公民,该项目将科学博览会式的示范带到当地的农贸市场。Topczewski教授和他的学生正在开发新的合成方法,用于(杂)芳基羧酸的脱羧交叉偶联和功能化。本研究的重点是反应周期的机理阐明,配体和金属配合物的优化,底物范围的扩大,以及更广泛的功能化反应的发展。研究了几种金属配合物及其脱羧偶联机理。这项工作的更广泛影响包括招募多样化的科学家队伍,培训他们成为化学社区的下一代领导者,并通过市场科学促进外展。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Gold Catalyzed Decarboxylative Cross-Coupling of Iodoarenes
  • DOI:
    10.1021/jacs.0c06244
  • 发表时间:
    2020-07-29
  • 期刊:
  • 影响因子:
    15
  • 作者:
    Daley, Ryan A.;Morrenzin, Aaron S.;Topczewski, Joseph J.
  • 通讯作者:
    Topczewski, Joseph J.
Combined Experimental and Computational Mechanistic Investigation of the Palladium-Catalyzed Decarboxylative Cross-Coupling of Sodium Benzoates with Chloroarenes
  • DOI:
    10.1021/acs.joc.1c00910
  • 发表时间:
    2021-08-02
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    Humke, Jenna N.;Daley, Ryan A.;Topczewski, Joseph J.
  • 通讯作者:
    Topczewski, Joseph J.
Mechanistic Investigation into the Gold-Catalyzed Decarboxylative Cross-Coupling of Iodoarenes
  • DOI:
    10.1021/acscatal.1c01631
  • 发表时间:
    2021-07-16
  • 期刊:
  • 影响因子:
    12.9
  • 作者:
    Daley, Ryan A.;Morrenzin, Aaron S.;Topczewski, Joseph J.
  • 通讯作者:
    Topczewski, Joseph J.
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Thomas Hoye其他文献

Thomas Hoye的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Thomas Hoye', 18)}}的其他基金

Hexadehydro-Diels-Alder (HDDA) Reaction-Enabled Synthesis of Structurally Elaborate, Polycyclic Aromatic Compounds
六氢狄尔斯-阿尔德 (HDDA) 反应合成结构精巧的多环芳香族化合物
  • 批准号:
    2155042
  • 财政年份:
    2022
  • 资助金额:
    $ 52万
  • 项目类别:
    Standard Grant
Using the Hexadehydro-Diels-Alder (HDDA) Reaction for the Facile Synthesis of Elaborated Polycyclic Aromatics
利用六氢狄尔斯-阿尔德 (HDDA) 反应轻松合成精制多环芳烃
  • 批准号:
    1665389
  • 财政年份:
    2017
  • 资助金额:
    $ 52万
  • 项目类别:
    Continuing Grant
Structure Determination by Computation of 1H NMR Chemical Shifts
通过计算 1H NMR 化学位移确定结构
  • 批准号:
    0911696
  • 财政年份:
    2009
  • 资助金额:
    $ 52万
  • 项目类别:
    Standard Grant
Studies of Highly Reactive Molecules and Intermediates
高反应性分子及中间体的研究
  • 批准号:
    8921744
  • 财政年份:
    1990
  • 资助金额:
    $ 52万
  • 项目类别:
    Continuing Grant
Hydrogen-Bonded Supermolecules: Synthesis of Host-Guest Complexes
氢键超分子:主客体复合物的合成
  • 批准号:
    8821778
  • 财政年份:
    1989
  • 资助金额:
    $ 52万
  • 项目类别:
    Continuing Grant

相似海外基金

Sustainable catalysis using palladium and gold compounds recovered from waste
使用从废物中回收的钯和金化合物进行可持续催化
  • 批准号:
    2887196
  • 财政年份:
    2023
  • 资助金额:
    $ 52万
  • 项目类别:
    Studentship
N-heterocyclic carbenes on bimetallic gold/palladium nanoparticles and their effect on surface structure and catalytic activity
双金属金/钯纳米粒子上的N-杂环卡宾及其对表面结构和催化活性的影响
  • 批准号:
    487841-2016
  • 财政年份:
    2017
  • 资助金额:
    $ 52万
  • 项目类别:
    Postdoctoral Fellowships
Elucidation of hydrogen absorption and desorption sites on palladium-gold alloy surfaces
钯金合金表面氢吸附和解吸位点的阐明
  • 批准号:
    16K04957
  • 财政年份:
    2016
  • 资助金额:
    $ 52万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
N-heterocyclic carbenes on bimetallic gold/palladium nanoparticles and their effect on surface structure and catalytic activity
双金属金/钯纳米粒子上的N-杂环卡宾及其对表面结构和催化活性的影响
  • 批准号:
    487841-2016
  • 财政年份:
    2016
  • 资助金额:
    $ 52万
  • 项目类别:
    Postdoctoral Fellowships
SusChEM: Collaborative Research - Granular Activated Carbon Supported Gold and Palladium Bimetals Catalysts for Sustainable Water Treatment
SusChEM:合作研究 - 用于可持续水处理的颗粒活性炭负载金和钯双金属催化剂
  • 批准号:
    1507707
  • 财政年份:
    2015
  • 资助金额:
    $ 52万
  • 项目类别:
    Standard Grant
SusChEM: Collaborative Research - Granular Activated Carbon Supported Gold and Palladium Bimetals Catalysts for Sustainable Water Treatment
SusChEM:合作研究 - 用于可持续水处理的颗粒活性炭负载金和钯双金属催化剂
  • 批准号:
    1508115
  • 财政年份:
    2015
  • 资助金额:
    $ 52万
  • 项目类别:
    Standard Grant
N-heterocyclic carbenes on bimetallic gold/palladium nanoparticles and their effect on surface structure and catalytic activity
双金属金/钯纳米粒子上的N-杂环卡宾及其对表面结构和催化活性的影响
  • 批准号:
    487841-2016
  • 财政年份:
    2015
  • 资助金额:
    $ 52万
  • 项目类别:
    Postdoctoral Fellowships
Surface Reaction Pathways on Model Gold Palladium Alloy Catalysts
模型金钯合金催化剂的表面反应路径
  • 批准号:
    1109377
  • 财政年份:
    2011
  • 资助金额:
    $ 52万
  • 项目类别:
    Continuing Grant
Pathfinding research for marine geochemistry of palladium, platinum and gold
钯、铂、金海洋地球化学探路研究
  • 批准号:
    22651006
  • 财政年份:
    2010
  • 资助金额:
    $ 52万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
DEVELOPMENT OF HIGHLY ACTIVE AND SELECTIVE GOLD PALLADIUM ALLOY CATALYSTS AIDED BY MICROREACTION TECHNOLOGY
微反应技术辅助开发高活性、选择性金钯合金催化剂
  • 批准号:
    EP/G007101/1
  • 财政年份:
    2009
  • 资助金额:
    $ 52万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了