CAREER: Palladium or Gold Catalyzed Decarboxylative Functionalization of (Hetero)Arenes

有了这个奖项，NSF化学部的化学合成计划正在支持明尼苏达大学双城分校的Joseph J. Topczewski教授的研究。该研究项目的重点是开发更有效的有机合成方法。在这项研究中，传统的起始材料被容易获得的，低能耗，更安全，毒性更小的羧酸所取代。这些新的合成方法正在取代先前用于合成药物、农用化学品和有机电子产品的反应。这项工作的更广泛的影响包括振兴和改造本科有机化学课程，并重点关注化学工业的先进制造方法。此外，大学生、研究生和教师还通过市场科学项目吸引明尼苏达州的市民，将科学博览会般的演示带到当地的农贸市场。Topczewski教授和他的学生正在开发新的合成方法，用于（杂）芳基羧酸的脱羧交叉偶联和官能化。本研究的重点是反应循环的机理阐明，配体和金属配合物的优化，底物范围的扩展，以及更广泛的功能化反应的发展。几种金属配合物和脱羧偶联机理正在研究中。这项工作的更广泛影响包括招募一批不同的科学家，培训他们成为化学界的下一代领导者，并通过市场科学促进外联。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Joseph J. Topczewski of the University of Minnesota-Twin Cities. This research project is focusing on developing more efficient methods for organic synthesis. In this research, traditional starting materials are replaced with readily available, lower energy, safer, and less toxic carboxylic acids. These new synthetic methods are replacing prior reactions used in the synthesis of medicines, agrochemicals, and organic electronics. The broader impacts of this work include revitalizing and transforming undergraduate organic chemistry courses and bring a focus on advanced manufacturing method for the chemical industry. Furthermore, undergraduate students, graduate students, and faculty are engaging the citizens of Minnesota through their Market Science program, which brings science fair-like demonstrations to local farmers’ markets.Professor Topczewski and his students are developing new synthetic methods for the decarboxylative cross-coupling and functionalization of (hetero)aryl carboxylic acids. This research focuses on the mechanistic elucidation of the reaction cycle, optimization of the ligand and metal complexes, expansion of the substrate scope, and the development of a broader array of functionalization reactions. Several metal complexes and mechanisms of decarboxylative coupling are being investigated. The broader impacts of this work include recruiting a diverse cohort of scientists to be trained as next generation leaders in the chemical community and promoting outreach through Market Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.