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CAREER: Palladium or Gold Catalyzed Decarboxylative Functionalization of (Hetero)Arenes

职业：钯或金催化（杂）芳烃的脱羧功能化

基本信息

批准号：
1942223
负责人：
Thomas Hoye
金额：
$ 52万
依托单位：
University of Minnesota-Twin Cities
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1942223&HistoricalAwards=false
关键词：
CAREER Palladium Gold Catalyzed Decarboxylative

项目摘要

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Joseph J. Topczewski of the University of Minnesota-Twin Cities. This research project is focusing on developing more efficient methods for organic synthesis. In this research, traditional starting materials are replaced with readily available, lower energy, safer, and less toxic carboxylic acids. These new synthetic methods are replacing prior reactions used in the synthesis of medicines, agrochemicals, and organic electronics. The broader impacts of this work include revitalizing and transforming undergraduate organic chemistry courses and bring a focus on advanced manufacturing method for the chemical industry. Furthermore, undergraduate students, graduate students, and faculty are engaging the citizens of Minnesota through their Market Science program, which brings science fair-like demonstrations to local farmers’ markets.Professor Topczewski and his students are developing new synthetic methods for the decarboxylative cross-coupling and functionalization of (hetero)aryl carboxylic acids. This research focuses on the mechanistic elucidation of the reaction cycle, optimization of the ligand and metal complexes, expansion of the substrate scope, and the development of a broader array of functionalization reactions. Several metal complexes and mechanisms of decarboxylative coupling are being investigated. The broader impacts of this work include recruiting a diverse cohort of scientists to be trained as next generation leaders in the chemical community and promoting outreach through Market Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

通过这一奖项，美国国家科学基金会化学部门的化学合成计划支持了明尼苏达大学双子城分校的约瑟夫·J·托普切夫斯基教授的研究。本研究项目致力于开发更有效的有机合成方法。在这项研究中，传统的起始原料被容易获得、能量更低、更安全、毒性更低的羧酸所取代。这些新的合成方法正在取代以前在药物、农用化学品和有机电子合成中使用的反应。这项工作的更广泛影响包括振兴和改造本科有机化学课程，并将重点放在化学工业的先进制造方法上。此外，本科生、研究生和教职员工正在通过他们的市场科学项目吸引明尼苏达州市民，该项目为当地农贸市场带来了类似科学博览会的演示。托普切夫斯基教授和他的学生正在开发新的合成方法，用于(杂)芳基羧酸的脱羧基交叉偶联和官能化。本研究侧重于反应循环的机理阐明、配体和金属络合物的优化、底物范围的扩大以及更广泛的官能化反应的发展。目前正在研究几种金属络合物和脱羧基偶联的机理。这项工作的更广泛的影响包括招募一批不同的科学家作为化学界的下一代领导者，并通过市场科学促进推广。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。