Hydrogen-Bonded Supermolecules: Synthesis of Host-Guest Complexes

氢键超分子：主客体复合物的合成

• 批准号: 8821778
• 负责人: Thomas Hoye
• 金额: $ 33.19万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1995-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821778&HistoricalAwards=false
• 关键词: Hydrogen; Bonded; Supermolecules; Synthesis; Host

The Organic Synthesis Program is supporting the work of Dr. Margaret Etter. Etter, a professor of chemistry at the University of Minnesota, is investigating how small molecules naturally organize themselves to form larger complexes. These newly organized aggregates have the unique ability to trap smaller molecules. This exciting area of chemistry is sometimes known as "host-guest" chemistry in recognition of the unique ability of the large complexes (hosts) to trap the smaller "guest" molecules, and is paving the way for the design of molecules that can mimic the biological catalysts, enzymes. The work involves the modelling, preparation, and characterization of hydrogen-bonded host-guest structures called cyclamers. These aggregates are formed from self-assembling smaller units through preferred hydrogen bonding interactions. Extensive molecular modelling to predict cavity sizes will be experimentally tested by examining the size of the guest molecules that the hosts can trap. Because of the hydrogen-bonded interactions in the host-guest relationship, the specificity expected should rival that from sigma-bonded macrocycles.

有机合成计划支持玛格丽特·埃特博士的工作。Etter是明尼苏达大学的化学教授，他正在研究小分子是如何自然地组织起来形成更大的复合物的。这些新组织的聚集体具有捕获较小分子的独特能力。这个令人兴奋的化学领域有时被称为“主-客”化学，以表彰大型复合物（宿主）捕获较小的“客”分子的独特能力，并为设计可以模仿生物催化剂，酶的分子铺平了道路。这项工作包括建模、制备和表征氢键主客体结构，称为环状环。这些聚集体是由自组装较小的单位通过首选氢键相互作用形成的。通过检查寄主可以捕获的客体分子的大小，将对预测空腔大小的广泛分子模型进行实验测试。由于主客体关系中的氢键相互作用，预期的特异性应该与sigma键大环相媲美。