Hydrogen-Bonded Supermolecules: Synthesis of Host-Guest Complexes

氢键超分子：主客体复合物的合成

• 批准号: 8821778
• 负责人: Thomas Hoye
• 金额: $ 33.19万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1995-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821778&HistoricalAwards=false
• 关键词: Hydrogen; Bonded; Supermolecules; Synthesis; Host

The Organic Synthesis Program is supporting the work of Dr. Margaret Etter. Etter, a professor of chemistry at the University of Minnesota, is investigating how small molecules naturally organize themselves to form larger complexes. These newly organized aggregates have the unique ability to trap smaller molecules. This exciting area of chemistry is sometimes known as "host-guest" chemistry in recognition of the unique ability of the large complexes (hosts) to trap the smaller "guest" molecules, and is paving the way for the design of molecules that can mimic the biological catalysts, enzymes. The work involves the modelling, preparation, and characterization of hydrogen-bonded host-guest structures called cyclamers. These aggregates are formed from self-assembling smaller units through preferred hydrogen bonding interactions. Extensive molecular modelling to predict cavity sizes will be experimentally tested by examining the size of the guest molecules that the hosts can trap. Because of the hydrogen-bonded interactions in the host-guest relationship, the specificity expected should rival that from sigma-bonded macrocycles.

有机合成计划是支持博士的工作。 玛格丽特·埃特 埃特尔是华盛顿大学的化学教授， 明尼苏达大学，正在研究小分子 自然地组织起来形成更大的复合体。 这些 新组织的聚集体具有独特的捕获能力， 小分子。 这个令人兴奋的化学领域 有时被称为“主客体”化学， 大型复合体（宿主）捕获 更小的“客体”分子，并为设计铺平了道路 模拟生物催化剂和酶的分子。 这项工作包括建模、准备和 氢键主客体结构表征 叫做仙客来。 这些聚集体是由 通过优选的氢自组装更小的单元 成键相互作用 广泛的分子建模预测 腔体尺寸将通过检查 宿主可以捕获的客体分子的大小 因为 主客体之间的氢键相互作用 关系，预期的特异性应该与 σ键合大环化合物。