Hydrogen-Bonded Supermolecules: Synthesis of Host-Guest Complexes

氢键超分子：主客体复合物的合成

• 批准号: 8821778
• 负责人: Thomas Hoye
• 金额: $ 33.19万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1995-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8821778&HistoricalAwards=false
• 关键词: Hydrogen; Bonded; Supermolecules; Synthesis; Host

The Organic Synthesis Program is supporting the work of Dr. Margaret Etter. Etter, a professor of chemistry at the University of Minnesota, is investigating how small molecules naturally organize themselves to form larger complexes. These newly organized aggregates have the unique ability to trap smaller molecules. This exciting area of chemistry is sometimes known as "host-guest" chemistry in recognition of the unique ability of the large complexes (hosts) to trap the smaller "guest" molecules, and is paving the way for the design of molecules that can mimic the biological catalysts, enzymes. The work involves the modelling, preparation, and characterization of hydrogen-bonded host-guest structures called cyclamers. These aggregates are formed from self-assembling smaller units through preferred hydrogen bonding interactions. Extensive molecular modelling to predict cavity sizes will be experimentally tested by examining the size of the guest molecules that the hosts can trap. Because of the hydrogen-bonded interactions in the host-guest relationship, the specificity expected should rival that from sigma-bonded macrocycles.

有机合成计划正在支持玛格丽特·埃特博士的工作。明尼苏达大学的化学教授埃特正在研究小分子是如何自然地组织起来形成更大的复合体的。这些新组织的聚集体具有捕获较小分子的独特能力。这一令人兴奋的化学领域有时被称为“主客体”化学，因为它认识到大型络合物(宿主)捕获较小“客体”分子的独特能力，并正在为设计能够模拟生物催化剂的分子--酶--铺平道路。这项工作涉及到氢键主客体结构的建模、制备和表征。这些聚集体是通过优先的氢键作用自组装较小的单元形成的。预测空腔大小的广泛分子模型将通过检查宿主可以捕获的客体分子的大小进行实验测试。由于主客体关系中的氢键相互作用，预期的特异性应该与西格玛键合大环相媲美。