Hydrogen-Bonded Supermolecules: Synthesis of Host-Guest Complexes
氢键超分子:主客体复合物的合成
基本信息
- 批准号:8821778
- 负责人:
- 金额:$ 33.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-05-01 至 1995-10-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The Organic Synthesis Program is supporting the work of Dr. Margaret Etter. Etter, a professor of chemistry at the University of Minnesota, is investigating how small molecules naturally organize themselves to form larger complexes. These newly organized aggregates have the unique ability to trap smaller molecules. This exciting area of chemistry is sometimes known as "host-guest" chemistry in recognition of the unique ability of the large complexes (hosts) to trap the smaller "guest" molecules, and is paving the way for the design of molecules that can mimic the biological catalysts, enzymes. The work involves the modelling, preparation, and characterization of hydrogen-bonded host-guest structures called cyclamers. These aggregates are formed from self-assembling smaller units through preferred hydrogen bonding interactions. Extensive molecular modelling to predict cavity sizes will be experimentally tested by examining the size of the guest molecules that the hosts can trap. Because of the hydrogen-bonded interactions in the host-guest relationship, the specificity expected should rival that from sigma-bonded macrocycles.
有机合成计划是支持博士的工作。 玛格丽特·埃特 埃特尔是华盛顿大学的化学教授, 明尼苏达大学,正在研究小分子 自然地组织起来形成更大的复合体。 这些 新组织的聚集体具有独特的捕获能力, 小分子。 这个令人兴奋的化学领域 有时被称为“主客体”化学, 大型复合体(宿主)捕获 更小的“客体”分子,并为设计铺平了道路 模拟生物催化剂和酶的分子。 这项工作包括建模、准备和 氢键主客体结构表征 叫做仙客来。 这些聚集体是由 通过优选的氢自组装更小的单元 成键相互作用 广泛的分子建模预测 腔体尺寸将通过检查 宿主可以捕获的客体分子的大小 因为 主客体之间的氢键相互作用 关系,预期的特异性应该与 σ键合大环化合物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas Hoye其他文献
Thomas Hoye的其他文献
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{{ truncateString('Thomas Hoye', 18)}}的其他基金
Hexadehydro-Diels-Alder (HDDA) Reaction-Enabled Synthesis of Structurally Elaborate, Polycyclic Aromatic Compounds
六氢狄尔斯-阿尔德 (HDDA) 反应合成结构精巧的多环芳香族化合物
- 批准号:
2155042 - 财政年份:2022
- 资助金额:
$ 33.19万 - 项目类别:
Standard Grant
CAREER: Palladium or Gold Catalyzed Decarboxylative Functionalization of (Hetero)Arenes
职业:钯或金催化(杂)芳烃的脱羧功能化
- 批准号:
1942223 - 财政年份:2020
- 资助金额:
$ 33.19万 - 项目类别:
Continuing Grant
Using the Hexadehydro-Diels-Alder (HDDA) Reaction for the Facile Synthesis of Elaborated Polycyclic Aromatics
利用六氢狄尔斯-阿尔德 (HDDA) 反应轻松合成精制多环芳烃
- 批准号:
1665389 - 财政年份:2017
- 资助金额:
$ 33.19万 - 项目类别:
Continuing Grant
Structure Determination by Computation of 1H NMR Chemical Shifts
通过计算 1H NMR 化学位移确定结构
- 批准号:
0911696 - 财政年份:2009
- 资助金额:
$ 33.19万 - 项目类别:
Standard Grant
Studies of Highly Reactive Molecules and Intermediates
高反应性分子及中间体的研究
- 批准号:
8921744 - 财政年份:1990
- 资助金额:
$ 33.19万 - 项目类别:
Continuing Grant
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