Patient-derived diseased and autologous immunocompetent skin models for the examination of drug-loaded nanocarrier systems (C02)

用于检查载药纳米载体系统的患者衍生的患病和自体免疫活性皮肤模型（C02）

• 批准号: 240271070
• 金额: --
• 依托单位: Berlin Institute of Health (BIH)
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/240271070?language=en
• 关键词: Patient; derived; diseased; autologous; immunocompetent

This project aims on the one hand to examine the complex interplay between nanocarriers and immune cells of the skin using an autologous, human-based immunocompetent skin model, which is reconstructed using hair-follicle derived outer root sheath cells and immune cells derived from the same donor. It will be used to study interactions between topically applied nanocarriers and skin immune cells. On the other hand a complex in vitro model of psoriasis will be developed via gene modulation and/or skin cells derived from psoriasis patients allowing one to determine drug effects in vitro and to detect the potential benefits but also side effects of drug-loaded nanocarriers.

该项目的目的一方面是使用自体的、基于人类的免疫活性皮肤模型来检查纳米载体和皮肤免疫细胞之间的复杂相互作用，该模型使用毛囊衍生的外根鞘细胞和来自同一供体的免疫细胞来重建。它将用于研究局部应用的纳米载体和皮肤免疫细胞之间的相互作用。另一方面，将通过基因调节和/或来自银屑病患者的皮肤细胞开发银屑病的复杂体外模型，从而允许人们在体外确定药物作用并检测载药纳米载体的潜在益处和副作用。