CAREER: Inorganic Scaffolds as Activity Based Probes for 19F Magnetic Resonance Biosensing

职业：无机支架作为 19F 磁共振生物传感活性探针

• 批准号: 1945401
• 负责人: Emily Que
• 金额: $ 67.5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1945401&HistoricalAwards=false
• 关键词: CAREER; Inorganic; Scaffolds; Activity; Based

In this CAREER project, funded by the Chemical Structure, Dynamics & Mechanisms-B Program of the Chemistry Division, Professor Emily Que of the Department of Chemistry at the University of Texas at Austin is developing new complexes for potential future use in medical applications such as Magnetic Resonance Imaging (MRI). Organisms and cells must exert precise control over their environments to maintain their natural balance. Professor Que and her group are developing metal complexes containing fluorine as these complexes are sensitive to potential changes in the cellular environment. The long-term goal of developing such complexes is for use in vivo imaging of biological changes using fluorine magnetic resonance imaging (MRI), an emerging "hot-spot" (localized) imaging technique that takes advantage of the fact that fluorine is not normally present in the cells of the human body. This project lies at the interface of synthetic inorganic chemistry and biology and will provide training to graduate and undergraduate students. Further educational impacts will be achieved through a research-focused training program with community college students including summer research internships, with the goal of recruiting this cohort of students into careers in STEM. Organisms and cells must exert precise control over their redox environments to maintain homeostasis. In order to gain further insight into the roles of redox changes in biology, Professor Que and her group are developing fluorinated metal complexes that display changes in fluorine NMR/MRI signals in response to changes in redox environment. The goal of this project is to understand how ligand structure influences both the reactivity and fluorine magnetic resonance properties of first row transition metal complexes (copper, iron and cobalt), and to integrate this research in inorganic bioimaging probe development through a community college research program. This project seeks to develop design principles for irreversible and reversible redox-active probes for bioreduction using copper and iron scaffolds. The researchers will also investigate how ligand modulation can improve the reactivity and fluorine magnetic resonance properties of fluorinated cobalt probes for biooxidation. They seek to improve recruitment and retention of underrepresented groups into STEM careers through hands-on a community college research program.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个由化学部化学结构，动力学机制-B计划资助的CAREER项目中，德克萨斯大学奥斯汀分校化学系的艾米丽Que教授正在开发新的复合物，用于磁共振成像（MRI）等医学应用。生物体和细胞必须对环境进行精确的控制，以保持其自然平衡。 Que教授和她的团队正在开发含氟的金属络合物，因为这些络合物对细胞环境的潜在变化敏感。 开发这种复合物的长期目标是使用氟磁共振成像（MRI）对生物变化进行体内成像，这是一种新兴的“热点”（局部）成像技术，其利用了氟通常不存在于人体细胞中的事实。该项目位于合成无机化学和生物学的接口，并将为研究生和本科生提供培训。进一步的教育影响将通过一个以研究为重点的培训计划与社区大学的学生，包括夏季研究实习，以招募这批学生进入干职业的目标实现。生物体和细胞必须对它们的氧化还原环境施加精确的控制以维持体内平衡。为了进一步深入了解氧化还原变化在生物学中的作用，Que教授和她的团队正在开发氟化金属络合物，这些络合物显示氟NMR/MRI信号的变化，以响应氧化还原环境的变化。该项目的目标是了解配体结构如何影响第一行过渡金属络合物（铜，铁和钴）的反应性和氟磁共振特性，并通过社区学院研究计划将这项研究整合到无机生物成像探针开发中。该项目旨在开发使用铜和铁支架进行生物还原的不可逆和可逆氧化还原活性探针的设计原则。 研究人员还将研究配体调制如何提高生物氧化氟化钴探针的反应性和氟磁共振特性。 该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响力审查标准进行评估，被认为值得支持。

项目成果

Design Strategies for Responsive Fluorine‐19 Magnetic Resonance Probes Using Paramagnetic Metal Complexes

使用顺磁性金属配合物的响应性氟 19 磁共振探针的设计策略

• DOI: 10.1002/anse.202200041
• 发表时间: 2022
• 期刊: Analysis & Sensing
• 作者: Ryan, Raphael T.;Scott, Kathleen M.;Que, Emily L.
• 通讯作者: Que, Emily L.

Versatile Nickel(II) Scaffolds as Coordination‐Induced Spin‐State Switches for 19 F Magnetic Resonance‐Based Detection

多功能镍 (II) 支架作为协调诱导自旋状态开关，用于基于 19 F 磁共振的检测

• DOI: 10.1002/anie.202010587
• 发表时间: 2020
• 期刊: Angewandte Chemie International Edition
• 作者: Xie, Da;Yu, Meng;Xie, Zhu‐Lin;Kadakia, Rahul T.;Chung, Chris;Ohman, Lauren E.;Javanmardi, Kamyab;Que, Emily L.
• 通讯作者: Que, Emily L.