Collaborative Research: OPUS: CRS: A Synthetic View of Evolutionary Heterogeneity and the Tree of Life
合作研究:OPUS:CRS:进化异质性和生命之树的综合观点
基本信息
- 批准号:1950759
- 负责人:
- 金额:$ 11.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The advent of inexpensive genome-scale DNA sequencing has led to major changes in the study of evolutionary history. Researchers now routinely assemble and analyze enormous genetic datasets in an effort to robustly resolve the patterns of evolutionary relatedness that together make up the global tree of life. While this shift has resulted in dramatic improvements in humanity’s understanding of evolutionary history, it brings important challenges. Chief among these is that evolution acts in heterogeneous ways across different regions of the genome and across the tree of life. This heterogeneity can be strong enough to frustrate analyses and, as a result, has led to a growing number of studies that arrive at fundamentally conflicting conclusions about evolutionary history, despite sampling large fractions of the genome and analyzing these with the field’s best available methods. This project will detect and quantify patterns of evolutionary heterogeneity in a large collection of genome-scale empirical datasets, mitigate the impacts of this heterogeneity, and develop a more accurate understanding of evolutionary history in the process.The research team will accomplish these goals by integrating a series of statistical tools that they have previously developed into a cohesive analytical strategy that can identify, explain, and resolve conflicting results. These tools include Bayesian techniques for measuring the fit between evolutionary models and data, as well as unbounded measures of statistical support. By integrating these tools and deploying them across a large collection of empirical datasets, the research team will develop a synthetic understanding of the most important drivers of evolutionary heterogeneity and conflicting results across the tree of life. This synthesis will lead to better techniques for identifying and mitigating the effects of evolutionary heterogeneity in massive datasets, enabling the field to develop a more accurate understanding of the history of life on earth. The research project will also provide new tools for visualizing evolutionary heterogeneity in phylogenetic trees, train graduate student researchers in both Hawaii and Louisiana, and develop a novel structured mentoring experience that will train a diverse group of beginning phylogenetic investigators in statistical phylogenomic methods.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
廉价的基因组规模DNA测序的出现导致了进化史研究的重大变化。研究人员现在经常收集和分析大量的遗传数据集,以努力有力地解决共同构成全球生命树的进化相关性模式。虽然这种转变极大地改善了人类对进化历史的理解,但也带来了重要的挑战。其中最主要的是,进化在基因组的不同区域和生命之树中以不同的方式起作用。这种异质性可能足够强大,足以挫败分析,因此,导致越来越多的研究得出关于进化历史的根本矛盾的结论,尽管对基因组的大部分进行采样并使用该领域最好的方法进行分析。该项目将在大量基因组规模的经验数据集中检测和量化进化异质性的模式,减轻这种异质性的影响,并在此过程中更准确地理解进化历史。研究团队将通过整合一系列统计工具来实现这些目标,他们以前开发了一个有凝聚力的分析策略,可以识别,解释,并解决冲突的结果。这些工具包括用于测量进化模型和数据之间的拟合的贝叶斯技术,以及统计支持的无界测量。通过整合这些工具并将其部署在大量的经验数据集上,研究团队将对进化异质性的最重要驱动因素和整个生命树中相互冲突的结果进行综合理解。这种综合将导致更好的技术来识别和减轻大规模数据集中进化异质性的影响,使该领域能够更准确地了解地球上的生命历史。该研究项目还将提供新的工具,用于可视化系统发育树中的进化异质性,培训夏威夷和路易斯安那州的研究生研究人员,该奖项反映了NSF的法定使命,并被认为是值得通过使用基金会的知识产权进行评估来支持的。优点和更广泛的影响审查标准。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Comparing Likelihood Ratios to Understand Genome-Wide Variation in Phylogenetic Support
- DOI:10.1093/sysbio/syac014
- 发表时间:2022-03-22
- 期刊:
- 影响因子:6.5
- 作者:Mount, Genevieve G.;Brown, Jeremy M.
- 通讯作者:Brown, Jeremy M.
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Jeremy Brown其他文献
TYM (Test Your Memory) Testing
TYM(测试你的记忆力)测试
- DOI:
10.1007/978-1-4471-2452-8_9 - 发表时间:
2013 - 期刊:
- 影响因子:0
- 作者:
Jeremy Brown - 通讯作者:
Jeremy Brown
Impaired C3b/iC3b deposition on Streptococcus pneumoniae in serum from patients with systemic lupus erythematosus.
系统性红斑狼疮患者血清中肺炎链球菌上的 C3b/iC3b 沉积受损。
- DOI:
10.1093/rheumatology/kep289 - 发表时间:
2009 - 期刊:
- 影响因子:5.5
- 作者:
F. Goldblatt;J. Yuste;D. Isenberg;Anisur Rahman;Jeremy Brown - 通讯作者:
Jeremy Brown
A marriage of convenience? A qualitative study of colleague supervision of master's level dissertations
- DOI:
10.1016/j.nedt.2010.12.025 - 发表时间:
2011-11-01 - 期刊:
- 影响因子:
- 作者:
Jennifer Kirton;Katherine Straker;Jeremy Brown;Barbara Jack;Annette Jinks - 通讯作者:
Annette Jinks
Efficient LiDAR-Based Object Segmentation and Mapping for Maritime Environments
适用于海洋环境的基于 LiDAR 的高效对象分割和测绘
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:4.1
- 作者:
D. Thompson;E. Coyle;Jeremy Brown - 通讯作者:
Jeremy Brown
Differential Expression of Cell Surface Markers by Ovine Respiratory Tract Dendritic Cells
绵羊呼吸道树突状细胞细胞表面标志物的差异表达
- DOI:
- 发表时间:
2006 - 期刊:
- 影响因子:3.2
- 作者:
T. McNeilly;Jeremy Brown;G. Harkiss - 通讯作者:
G. Harkiss
Jeremy Brown的其他文献
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{{ truncateString('Jeremy Brown', 18)}}的其他基金
Isolation and characterisation of monoclonal antibodies for the treatment or prevention of antibiotic resistant Acinetobacter baumannii infections
用于治疗或预防抗生素耐药鲍曼不动杆菌感染的单克隆抗体的分离和表征
- 批准号:
MR/Y008693/1 - 财政年份:2024
- 资助金额:
$ 11.3万 - 项目类别:
Research Grant
Identifying the correlates of protection against Streptococcus pneumoniae respiratory tract infection using a human challenge model
使用人体挑战模型确定预防肺炎链球菌呼吸道感染的相关性
- 批准号:
MR/Z503721/1 - 财政年份:2024
- 资助金额:
$ 11.3万 - 项目类别:
Research Grant
Travel: Improving the Utility of Haptic Feedback in Upper-Limb Prosthesis Control: Establishing user-centric guidelines for engineering innovation
旅行:提高上肢假肢控制中触觉反馈的效用:建立以用户为中心的工程创新指南
- 批准号:
2331318 - 财政年份:2023
- 资助金额:
$ 11.3万 - 项目类别:
Standard Grant
CAREER: Improving Prosthesis Usability through Enhanced Touch Feedback and Intelligent Control
职业:通过增强的触摸反馈和智能控制提高假肢的可用性
- 批准号:
2146206 - 财政年份:2022
- 资助金额:
$ 11.3万 - 项目类别:
Standard Grant
Collaborative Research: CIBR: CloudForest: A Portable Cyberinfrastructure Workflow To Advance Biological Insight from Massive, Heterogeneous Phylogenomic Datasets
合作研究:CIBR:CloudForest:一种便携式网络基础设施工作流程,可从海量、异质的系统发育数据集中推进生物学洞察
- 批准号:
1934156 - 财政年份:2019
- 资助金额:
$ 11.3万 - 项目类别:
Standard Grant
CHS: Small: Understanding Environment Perception and Task Performance in Human-in-the-Loop Tele-robotic Systems (HiLTS)
CHS:小型:了解人在环远程机器人系统 (HiLTS) 中的环境感知和任务性能
- 批准号:
1910939 - 财政年份:2019
- 资助金额:
$ 11.3万 - 项目类别:
Continuing Grant
Adjunct antibody therapy for severe antibiotic-resistant Acinetobacter baumannii infections
严重抗生素耐药鲍曼不动杆菌感染的辅助抗体治疗
- 批准号:
MR/S004394/1 - 财政年份:2018
- 资助金额:
$ 11.3万 - 项目类别:
Research Grant
Universal protection against Streptococcus pneumoniae by recombinant glycoconjugate vaccines
重组糖复合物疫苗对肺炎链球菌具有普遍保护作用
- 批准号:
MR/R001871/1 - 财政年份:2018
- 资助金额:
$ 11.3万 - 项目类别:
Research Grant
Adjunct antibody therapy for severe antibiotic-resistant Acinetobacter baumannii infections
严重抗生素耐药鲍曼不动杆菌感染的辅助抗体治疗
- 批准号:
MC_PC_17227 - 财政年份:2018
- 资助金额:
$ 11.3万 - 项目类别:
Intramural
Training in Innovative Phylogenetics and Comparative Methods at the Society of Systematic Biologists Meeting, January, 2017, Baton Rouge, Louisiana
系统生物学家协会会议上的创新系统发育学和比较方法培训,2017 年 1 月,路易斯安那州巴吞鲁日
- 批准号:
1723656 - 财政年份:2017
- 资助金额:
$ 11.3万 - 项目类别:
Standard Grant
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