SBIR Phase II: Lignin-Based Formulations for Efficient and Sustainable Control of Plant Pathogens

SBIR 第二阶段：用于有效和可持续控制植物病原体的木质素配方

• 批准号: 1950915
• 负责人: Anka Veleva
• 金额: $ 75万
• 依托单位: BENANOVA Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950915&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Lignin; Based

This Small Business Innovation Research (SBIR) Phase II project focuses on addressing environmental challenges associated with extensive use of synthetic agrochemicals by developing novel sustainable nanoformulations for efficient management of bacterial and fungal pathogens. The broader impacts of this research and development effort are important on several levels; the sustainable agricultural treatments developed in this project could help protect natural resources, enhance security of the national food supply by reducing crop losses, and improve public health. While the initial focus is on efficient delivery of anti-microbial and anti-fungal crop protection chemicals, this platform can be applied for actives and biologicals with other functionalities. Thus, in addition to agricultural crop protection products, the environmentally benign nanoparticle delivery system developed in the project may find future applications in many products targeted to the consumer market, construction, personal care and healthcare. This SBIR Phase II project will advance the development of a novel platform where engineered nanoparticles made from sustainable materials will replace harmful and persistent synthetic chemical agents used presently. The research objective is to utilize the widely available bio-renewable resource lignin as a natural non-persistent bio-degradable delivery system for agricultural actives. Colloidal particles made of technical lignin will be fabricated in large amounts by non-solvent precipitation in a continuous, green, low-cost method and then functionalized for stability and improved targeted attachment to the plant foliage. A multi-disciplinary approach is proposed to characterize thoroughly the new formulations and correlate their material characteristics and agronomic performance. This new knowledge will make possible to develop physico-chemical means of enhancing their field efficacy. In addition, research will focus on safety evaluation via human health risk assessment.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）II期项目着重于解决与合成农业化学物质相关的环境挑战，通过开发新型的可持续纳米制剂来有效地管理细菌和真菌病原体。这项研究和发展工作的更广泛的影响在多个层面上很重要。该项目开发的可持续农业治疗方法可以帮助保护自然资源，通过减少农作物损失并改善公共卫生来增强国家粮食供应的安全。虽然最初的重点是有效地递送抗微生物和抗真菌作物保护化学品，但该平台可以用于具有其他功能的活性和生物学。因此，除了农业作物保护产品外，该项目中开发的环境良性纳米颗粒输送系统可能会在许多针对消费者市场，建筑，个人护理和医疗保健的产品中找到未来的应用。这个SBIR II期项目将推动开发一个新型平台，在该平台中，由可持续材料制成的工程纳米颗粒将取代目前使用的有害和持续的合成化学剂。研究目标是利用广泛可用的生物可再生资源木质素作为农业活性生物的天然非持久性生物降解系统。由技术木质素制成的胶体颗粒将通过在连续的，绿色的低成本方法中通过非溶剂沉淀大量制造，然后功能化以稳定并改善靶向植物叶子的靶向附件。提出了一种多学科的方法，以彻底表征新的配方并将其物质特征和农艺性能相关联。这些新知识将有可能开发出增强其现场功效的物理化学方法。此外，研究将通过人类健康风险评估重点放在安全评估上。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的评论标准来评估的。