SBIR Phase II: Lignin-Based Formulations for Efficient and Sustainable Control of Plant Pathogens

SBIR 第二阶段：用于有效和可持续控制植物病原体的木质素配方

• 批准号: 1950915
• 负责人: Anka Veleva
• 金额: $ 75万
• 依托单位: BENANOVA Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950915&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Lignin; Based

This Small Business Innovation Research (SBIR) Phase II project focuses on addressing environmental challenges associated with extensive use of synthetic agrochemicals by developing novel sustainable nanoformulations for efficient management of bacterial and fungal pathogens. The broader impacts of this research and development effort are important on several levels; the sustainable agricultural treatments developed in this project could help protect natural resources, enhance security of the national food supply by reducing crop losses, and improve public health. While the initial focus is on efficient delivery of anti-microbial and anti-fungal crop protection chemicals, this platform can be applied for actives and biologicals with other functionalities. Thus, in addition to agricultural crop protection products, the environmentally benign nanoparticle delivery system developed in the project may find future applications in many products targeted to the consumer market, construction, personal care and healthcare. This SBIR Phase II project will advance the development of a novel platform where engineered nanoparticles made from sustainable materials will replace harmful and persistent synthetic chemical agents used presently. The research objective is to utilize the widely available bio-renewable resource lignin as a natural non-persistent bio-degradable delivery system for agricultural actives. Colloidal particles made of technical lignin will be fabricated in large amounts by non-solvent precipitation in a continuous, green, low-cost method and then functionalized for stability and improved targeted attachment to the plant foliage. A multi-disciplinary approach is proposed to characterize thoroughly the new formulations and correlate their material characteristics and agronomic performance. This new knowledge will make possible to develop physico-chemical means of enhancing their field efficacy. In addition, research will focus on safety evaluation via human health risk assessment.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个小企业创新研究（SBIR）第二阶段项目的重点是通过开发新的可持续纳米配方来有效管理细菌和真菌病原体，解决与广泛使用合成农用化学品相关的环境挑战。这项研究和开发工作的更广泛影响在几个层面上都很重要；本项目开发的可持续农业处理方法有助于保护自然资源，通过减少作物损失加强国家粮食供应安全，并改善公众健康。虽然最初的重点是抗微生物和抗真菌作物保护化学品的有效输送，但该平台可以应用于具有其他功能的活性物质和生物制剂。因此，除了农业作物保护产品外，该项目开发的环境友好型纳米颗粒输送系统未来可能会在许多针对消费市场、建筑、个人护理和医疗保健的产品中找到应用。SBIR二期项目将推进一个新平台的开发，在这个平台上，由可持续材料制成的工程纳米颗粒将取代目前使用的有害和持久性合成化学剂。研究目的是利用广泛利用的生物可再生资源木质素作为一种天然的非持久性可生物降解的农业活性物质的输送系统。由技术木质素制成的胶体颗粒将通过非溶剂沉淀法以连续、绿色、低成本的方法大量制备，然后进行功能化以获得稳定性和改善对植物叶片的靶向附着。提出了一种多学科的方法来彻底表征新配方，并将其材料特性和农艺性能联系起来。这一新知识将使开发物理化学方法来提高其野外药效成为可能。此外，研究将侧重于通过人体健康风险评估进行安全性评价。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。