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Light-induced liquid flow control for biomimetic retinal implants and therapies

用于仿生视网膜植入物和治疗的光诱导液体流动控制

基本信息

批准号：
1952469
负责人：
Sang-Woo Seo
金额：
$ 35万
依托单位：
CUNY City College
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1952469&HistoricalAwards=false
关键词：
Light induced liquid flow control

项目摘要

Abstract: Retinal prosthesis is a type of neural prosthesis, which is an implant process to restore or treat damaged sensory elements in the neural system. It is well known that complex information transfer in neural cells is primarily through biochemical reactions. Neurotransmitter-based chemical stimulation is a relatively new concept and has demonstrated its potential to mimic neural information processing. However, most of the current efforts rely on limited cell numbers and their responses because of the lack of appropriate methods to investigate large cell populations. Neural cell arrangement in the retina is especially in a highly arrayed configuration. As such, their neural activities are interconnected with surrounding cells. To better understand the large-scale neural signal processing and develop clinically applicable neural prostheses, it is important to mimic the synaptic functionality of releasing neurotransmitters in a large, arrayed configuration with high spatial resolution. The proposed research work will provide a solution for this critical need and develop light-induced liquid flow control, especially for large-scale chemical stimulation. In addition to the technical impacts, the broader impact of the proposed program will be the education and training of a new generation of workforces for future scientific community. The City College of New York is well-positioned to attract its dominant underrepresented minorities. The project will integrate the research activities into the current curriculum to provide undergraduate and graduate students with hands-on experience and research opportunities. The proposed research activities will also be integrated into outreach activities through lab demos, tours, and summer internships for high school students. The overall goal of the proposed research program is to advance the scientific and technological foundations for large-arrayed neurotransmitter-based chemical stimulation with application to retinal prosthesis. The project will implement a self-powered, three-dimensional microfluidic platform to address the fundamental limitations of the current chemical stimulation approach when it is applied to highly interconnected, large arrayed neural stimulation. Two control mechanisms will be studied. One is based on light-induced electroosmotic effect, and the other is based on light-induced physical on-off valves using stimulus-responsive polymers. The successful completion of this project will significantly simplify overall system complexities for chemically stimulating densely populated cells and initiate a new paradigm of chemical stimulation that can be potentially applied to large-area, with high spatial resolution, without limiting its scalability. The resulting platform will have broad impacts of translating the current chemical stimulation approach from a bench-top laboratory setting to practical neural prostheses and therapies.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

摘要：视网膜假体是一种神经假体，是一种修复或治疗神经系统中受损感觉元素的植入过程。众所周知，神经细胞中的复杂信息传递主要是通过生化反应进行的。基于神经递质的化学刺激是一个相对较新的概念，并已证明其模拟神经信息处理的潜力。然而，由于缺乏适当的方法来研究大细胞群，目前的大多数努力依赖于有限的细胞数量及其反应。神经细胞在视网膜中的排列尤其高度排列。因此，它们的神经活动与周围的细胞相互联系。为了更好地理解大规模神经信号处理和开发临床应用的神经假体，在高空间分辨率的大阵列配置中模拟释放神经递质的突触功能非常重要。提出的研究工作将为这一关键需求提供解决方案，并开发光诱导液体流动控制，特别是大规模化学刺激。除了技术上的影响外，拟议计划的更广泛影响将是未来科学界新一代劳动力的教育和培训。纽约城市学院（City College of New York）在吸引占主导地位的未被充分代表的少数族裔方面处于有利地位。该项目将把研究活动整合到现有课程中，为本科生和研究生提供实践经验和研究机会。拟议的研究活动还将通过实验室演示、参观和高中生暑期实习等形式整合到拓展活动中。提出的研究计划的总体目标是推进基于大阵列神经递质的化学刺激应用于视网膜假体的科学和技术基础。该项目将实现一个自供电的三维微流控平台，以解决当前化学刺激方法在应用于高度互联的大型阵列神经刺激时的基本局限性。将研究两种控制机制。一种是基于光诱导的电渗透效应，另一种是基于光诱导的物理开关阀，使用刺激响应聚合物。该项目的成功完成将大大简化化学刺激密集细胞的整体系统复杂性，并开创了一种新的化学刺激模式，可以应用于大面积，高空间分辨率，而不限制其可扩展性。由此产生的平台将对将目前的化学刺激方法从台式实验室环境转化为实用的神经假体和治疗产生广泛的影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。