IRES Track I: Process Development for Cell and Tissue Biomanufacturing

IRES Track I:细胞和组织生物制造工艺开发

基本信息

  • 批准号:
    1952614
  • 负责人:
  • 金额:
    $ 30万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

This IRES program provides U.S. students with a collaborative, international bioprocess development and cell and tissue biomanufacturing research experience with a U.S. and German team. Although our nation has made large investments and achieved great progress in identifying biotechnologies that can be used to repair the human body following injury or disease, there is a critical need for engineering expertise to implement these discoveries, bringing them from the lab bench to commercial products. Knowledge and platforms to enable industrial scale cell and tissue biomanufacturing are critical for realizing clinical treatments and maximizing the societal benefits from the long-term research in these fields. Whereas human pluripotent stem cells (hPSCs) can now, in principle, be reliably differentiated into multiple therapeutic cell types, production of sufficient numbers of cells for clinical therapy is not yet typically feasible. Establishing the bioprocessing capabilities required to manufacture cells and tissues for commercial and clinical regenerative applications requires international and interdisciplinary student researcher training. This IRES program engages and trains students in applying their engineering and biological expertise to this problem in a research location, Germany/Hannover Medical School/LEBAO, which is at the forefront in this area. The overall goal is to produce scientists and engineers with strong technical communication and problem-solving skills and who have strong cultural competency and can work effectively with international partners to further our ability to repair the human body.This IRES project establishes an international research and education partnership/program in process development for cell and tissue biomanufacturing between Auburn University (AU) and Hannover Medical School (MHH, Germany). This collaborative international research program will train 15 undergraduate and graduate student researchers over the course of three years in interrelated projects on process development for cell and tissue biomanufacturing at the MHH in Germany. Students are engaged both in an individual research project and in cohesive efforts of the integrated research team. Undergraduate and graduate student researchers are recruited through existing, strong biomanufacturing research ties with Alabama State University, an HBCU, and the AU Engineering’s state-wide network on community colleges, in addition to engaging AU students already working collaboratively with LEBAO faculty. Reflective writing and ePortfolios are used to guide students learning experiences. Students will gain subject expertise and practice technical communication skills through regular individual projects presentations to the IRES student cohort and PI, culminating a research poster presentation for members of the host institute and their local home institutions. Through formation of this diverse team of undergraduate and graduate researchers and their engagement in an international learning and research environment, the program facilitates acquisition of intercultural skills and greater global competency. The objective of this IRES project is to provide students with a high-quality international research experience, increase student retention and diversity, advance students’ knowledge of culture and scientific education and to promote their personal network development and carrier opportunities on a trans-institutional and trans-Atlantic level.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该IRES项目为美国学生提供与美国和德国团队合作的国际生物工艺开发以及细胞和组织生物制造研究经验。尽管我们国家在确定可用于修复受伤或疾病后人体的生物技术方面进行了大量投资,并取得了很大进展,但仍迫切需要工程专业知识来实施这些发现,将它们从实验室带到商业产品。能够实现工业化规模的细胞和组织生物制造的知识和平台对于实现临床治疗和最大化这些领域的长期研究的社会效益至关重要。虽然人类多能干细胞(HPSCs)现在原则上可以可靠地分化为多种治疗细胞类型,但生产足够数量的细胞用于临床治疗通常还不可行。建立制造用于商业和临床再生应用的细胞和组织所需的生物处理能力需要国际和跨学科的学生研究人员培训。IRES项目致力于并培训学生在德国/汉诺威医学院/乐宝的一个研究地点将他们的工程和生物专业知识应用于这个问题,该研究地点在该领域处于领先地位。IRES项目的总体目标是培养具有强大的技术沟通和解决问题能力的科学家和工程师,他们具有强大的文化能力,能够有效地与国际合作伙伴合作,进一步提高我们修复人体的能力。这个IRES项目在奥本大学(AU)和德国汉诺威医学院(MHH)之间建立了一个细胞和组织生物制造的国际研究和教育合作伙伴关系/计划。这一合作的国际研究项目将在为期三年的课程中培训15名本科生和研究生研究人员,这些研究人员涉及德国MHH细胞和组织生物制造工艺开发的相关项目。学生既参与个人研究项目,又参与综合研究团队的凝聚力。本科生和研究生研究人员通过与阿拉巴马州立大学、HBCU和AU Engineering的全州社区大学网络建立的现有强大的生物制造研究关系来招募,此外还吸引已经与乐宝教员合作的AU学生。反思性写作和ePortfolios被用来指导学生的学习体验。学生将通过定期向IRES学生群体和PI进行个人项目演示来获得学科专业知识和练习技术沟通技能,最终将为主办机构及其当地机构的成员提供研究海报演示。通过组建这个由本科生和研究生组成的不同团队,以及他们在国际学习和研究环境中的参与,该项目促进了跨文化技能的获得和更大的全球能力。IRES项目的目标是为学生提供高质量的国际研究体验,增加学生的保留率和多样性,提高学生的文化和科学教育知识,并在跨机构和跨大西洋的层面上促进他们的个人网络发展和载体机会。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Elizabeth Lipke其他文献

P31-042-23 An Improved In Vitro 3T3-L1 Adipocyte Model of Inflammation and Insulin Resistance
  • DOI:
    10.1016/j.cdnut.2023.101607
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Ifeoluwa Odeniyi;Bulbul Ahmed;Benjamin Anbiah;Grace Hester;Iman Hassani;Elizabeth Lipke;Michael Greene
  • 通讯作者:
    Michael Greene
P23-001-23 Role of CXCL7 in Colon Cancer Progression
  • DOI:
    10.1016/j.cdnut.2023.100114
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
  • 作者:
    Hadeel Aldhowayan;Elizabeth Lipke;Michael Greene
  • 通讯作者:
    Michael Greene

Elizabeth Lipke的其他文献

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{{ truncateString('Elizabeth Lipke', 18)}}的其他基金

PFI-TT: An Automated Platform for Production and Distribution of Engineered Tissue Microspheres
PFI-TT:工程组织微球生产和分销的自动化平台
  • 批准号:
    2141205
  • 财政年份:
    2022
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
I-Corps: Spheroidal engineered tissues for more efficient drug discovery
I-Corps:球形工程组织可提高药物发现效率
  • 批准号:
    2107931
  • 财政年份:
    2021
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Collaborative Research: RECODE: Directing and Controlling Cardiac Differentiation Through Cellular and Microenvironmental Manipulation and Application of Machine-Learning
合作研究:RECODE:通过细胞和微环境操纵以及机器学习的应用来指导和控制心脏分化
  • 批准号:
    2135059
  • 财政年份:
    2021
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
Data-Driven Model Development for Cost-Effective, Reliable Cardiac Tissue Manufacturing
数据驱动模型开发,实现经济高效、可靠的心脏组织制造
  • 批准号:
    1743445
  • 财政年份:
    2017
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant
CAREER:Injectable Biomimetic Scaffolds to Direct Stem Cell-Derived Cardiomyocyte Differentiation
职业:可注射仿生支架指导干细胞衍生的心肌细胞分化
  • 批准号:
    1150854
  • 财政年份:
    2012
  • 资助金额:
    $ 30万
  • 项目类别:
    Standard Grant

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